Article Figures & Data
Figures
- Figure 1.
Metabolic and physiologic parameters. (A) Fasting blood glucose at 24 to 26 wk in db/db mice and age-matched controls ± eNOS−/−. *P < 0.05 versus control and eNOS−/−. Values are means ± SE of at least eight mice. (B) Systolic BP. *P < 0.05 eNOS−/− or eNOS−/− db/db versus control or db/db. Values are means ± SE of at least four mice.
- Figure 2.
Functional renal parameters. (A) Urinary albumin/creatinine ratio (ACR) at 24 to 26 wk of age. Values are means ± SE of at least eight mice. *P < 0.05 versus respective controls, db/db, and eNOS−/−. (B) GFR in diabetic mice. *P < 0.05 versus control, db/db, and eNOS−/−. Values are means ± SE of at least eight mice. (C) Correlation of serum creatinine with GFR.
- Figure 3.
Glomerular histopathology. (A) Representative glomerular lesions of diabetic mouse kidneys at 24 to 26 wk: control (a); db/db (b and e); eNOS−/− (c); eNOS−/−db/db (d and f). (f) Arteriolar hyalinosis (big arrow) and early nodular glomerulosclerosis (small arrow) in eNOS−/− db/db mice (periodic acid-Schiff). (B) Glomerular fibronectin expression in control (a), db/db (b), eNOS−/− (c), and eNOS−/− db/db mice (d). (C) Glomerular injury scores in diabetic mice. Mesangial expansion and sclerosis were scored on a scale from 0 to 4+ as described in The Materials and Methods section. *P < 0.05, eNOS−/− db/db (24 to 26 wk) mice versus age-matched controls, db/db, and eNOS−/− mice. (D) Correlation of glomerular injury index with albuminuria. (E) Electron micrographs of glomeruli (16 wk). Opposed arrows indicate GBM. GBM thickening was notable in eNOS−/−db/db mice (c) compared with control (a) and db/db mice (b). Magnifications: ×400 in A, a through d, and B; ×200 in A, e and f.
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