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Clinical Dialysis
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Effects of Resistance Exercise Training and Nandrolone Decanoate on Body Composition and Muscle Function among Patients Who Receive Hemodialysis: A Randomized, Controlled Trial

Kirsten L. Johansen, Patricia L. Painter, Giorgos K. Sakkas, Patricia Gordon, Julie Doyle and Tiffany Shubert
JASN August 2006, 17 (8) 2307-2314; DOI: https://doi.org/10.1681/ASN.2006010034
Kirsten L. Johansen
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Patricia L. Painter
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Giorgos K. Sakkas
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Patricia Gordon
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Julie Doyle
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Tiffany Shubert
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Abstract

Patients who are on hemodialysis commonly experience muscle wasting and weakness, which have a negative effect on physical functioning and quality of life. The objective of this study was to determine whether anabolic steroid administration and resistance exercise training induce anabolic effects among patients who receive maintenance hemodialysis. A randomized 2 × 2 factorial trial of anabolic steroid administration and resistance exercise training was conducted in 79 patients who were receiving maintenance hemodialysis at University of California, San Francisco–affiliated dialysis units. Interventions included double-blinded weekly nandrolone decanoate (100 mg for women; 200 mg for men) or placebo injections and lower extremity resistance exercise training for 12 wk during hemodialysis sessions three times per week using ankle weights. Primary outcomes included change in lean body mass (LBM) measured by dual-energy x-ray absorptiometry, quadriceps muscle cross-sectional area measured by magnetic resonance imaging, and knee extensor muscle strength. Secondary outcomes included changes in physical performance, self-reported physical functioning, and physical activity. Sixty-eight patients completed the study. Patients who received nandrolone decanoate increased their LBM by 3.1 ± 2.2 kg (P < 0.0001). Exercise did not result in a significant increase in LBM. Quadriceps muscle cross-sectional area increased in patients who were assigned to exercise (P = 0.01) and to nandrolone (P < 0.0001) in an additive manner. Patients who exercised increased their strength in a training-specific fashion, and exercise was associated with an improvement in self-reported physical functioning (P = 0.04 compared with nonexercising groups). Nandrolone decanoate and resistance exercise produced anabolic effects among patients who were on hemodialysis. Further studies are needed to determine whether these interventions improve survival.

  • © 2006 American Society of Nephrology
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Journal of the American Society of Nephrology: 17 (8)
Journal of the American Society of Nephrology
Vol. 17, Issue 8
August 2006
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Effects of Resistance Exercise Training and Nandrolone Decanoate on Body Composition and Muscle Function among Patients Who Receive Hemodialysis: A Randomized, Controlled Trial
Kirsten L. Johansen, Patricia L. Painter, Giorgos K. Sakkas, Patricia Gordon, Julie Doyle, Tiffany Shubert
JASN Aug 2006, 17 (8) 2307-2314; DOI: 10.1681/ASN.2006010034

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Effects of Resistance Exercise Training and Nandrolone Decanoate on Body Composition and Muscle Function among Patients Who Receive Hemodialysis: A Randomized, Controlled Trial
Kirsten L. Johansen, Patricia L. Painter, Giorgos K. Sakkas, Patricia Gordon, Julie Doyle, Tiffany Shubert
JASN Aug 2006, 17 (8) 2307-2314; DOI: 10.1681/ASN.2006010034
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More in this TOC Section

  • Comparison of Survival of Upper Arm Arteriovenous Fistulas and Grafts after Failed Forearm Fistula
  • Progressive Exercise for Anabolism in Kidney Disease (PEAK): A Randomized, Controlled Trial of Resistance Training during Hemodialysis
  • Soluble CD154 Is a Unique Predictor of Nonfatal and Fatal Atherothrombotic Events in Patients Who Have End-Stage Renal Disease and Are on Hemodialysis
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  • Endogenous Testosterone and Mortality in Male Hemodialysis Patients: Is It the Result of Aging?
  • Resistance Training Increases Muscle Mitochondrial Biogenesis in Patients with Chronic Kidney Disease
  • Temporal Trends in Health-Related Quality of Life among Hemodialysis Patients in the United States
  • Given the Science on Malnutrition, How Does the Clinician Respond? Practical Lessons for and Application to the Dialysis Patient
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  • Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients
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