Chronic Kidney Disease

Association between Multidisciplinary Care and Survival for Elderly Patients with Chronic Kidney Disease

Brenda R. Hemmelgarn, Braden J. Manns, Jianguo Zhang, Marcello Tonelli, Scott Klarenbach, Michael Walsh, Bruce F. Culleton and ; for the Alberta Kidney Disease Network
JASN March 2007, 18 (3) 993-999; DOI: https://doi.org/10.1681/ASN.2006080860

Abstract

The effectiveness of multidisciplinary care (MDC) in improving health outcomes for patients with chronic kidney disease (CKD) is uncertain. This study sought to determine the association among MDC, survival, and risk for hospitalization among elderly outpatients with CKD. A total of 6978 patients who were 66 yr and older and had CKD were identified between July 1 and December 31, 2001, and followed to December 31, 2004; 187 (2.7%) were followed in an MDC clinic. Logistic regression was used to determine the propensity score (probability of MDC) for each patient, and MDC and non-MDC patients then were matched 1:1 on the basis of their score. A Cox model was used to determine the association between MDC and risk for death and hospitalization. After adjustment for age, gender, baseline GFR, diabetes, and comorbidity score, there was a 50% reduction in the risk for death for the MDC compared with the non-MDC group (hazard ratio [HR] 0.50; 95% confidence interval [CI] 0.35 to 0.71). There was no difference in the risk for all-cause (HR 0.83; 95% CI 0.64 to 1.06) or cardiovascular-specific hospitalization (HR 0.76; 95% CI 0.54 to 1.06) for the MDC compared with the non-MDC group. In conclusion, it was found that MDC was associated with a significant reduction in the risk for all-cause mortality and, although not statistically significant, a trend toward a reduction in risk for all-cause and cardiovascular-specific hospitalizations. The benefits of MDC and an assessment of their economic impact should be tested in a randomized, controlled trial.

Chronic kidney disease (CKD) is common and is associated with a poor prognosis, including the development of premature cardiovascular disease and increased mortality (1–5). Given the multiple comorbidities and complexity of care for patients with CKD, it has been proposed that multidisciplinary care (MDC) that is delivered by an interdisciplinary health care team may improve health outcomes in this patient population (6–8).

MDC clinics are being used by the majority of nephrology programs in North America (9), even though their effectiveness in improving morbidity and mortality outcomes for patients with CKD largely is unknown. Although observational studies suggested a survival advantage with MDC (10,11), these studies were limited to patients who initiated dialysis, thereby introducing a potential survival bias. An earlier randomized trial of patients with CKD found no effect of MDC compared with usual care on decline in kidney function, health care utilization, or mortality (12). A more recent randomized trial suggested that MDC was not associated with improvement in vascular structure or function in patients with stages 4 and 5 CKD (13), although a psychoeducational intervention alone did demonstrate an extension in time to initiation of renal replacement therapy and improved survival (14,15). However, these trials have limitations, including reliance on primary care physicians to implement recommendations (12), inclusion of patients who already are on dialysis (13), and an educational intervention administered without MDC as it currently exists (14,15). In contrast, randomized trials of MDC in other chronic disease conditions have been shown to result in improved morbidity and mortality (16–20). Given the uncertainty with respect to the effectiveness and the resource intensity that is associated with MDC, we sought to determine the association among MDC, survival, and risk for hospitalization among elderly outpatients with CKD, compared with usual care.

Materials and Methods

Data Sources and Identification of Study Population

We identified a cohort of elderly patients with CKD from the Calgary Laboratory Services computerized database (Calgary, AL, Canada). Calgary Laboratory Services provides laboratory testing to the entire Calgary Health Region (catchment population 1.1 million) using a single regional laboratory and standardized methods. To be eligible for inclusion, patients had to be 66 yr or older and have had at least one outpatient serum creatinine measurement during a 6-mo period (July 1, 2001, to December 31, 2001). Laboratory measurements that were associated with a hospital admission were excluded to avoid episodes of acute renal failure. The first outpatient serum creatinine measurement during this period was used to define the index GFR.

The cohort was linked to the Southern Alberta Renal Program computerized database, and all patients followed in the MDC clinic during the 18-mo period from July 1, 2001, to December 31, 2002, were identified (both incident and prevalent MDC patients). The Southern Alberta Renal Program provides care to all patients with ESRD in southern Alberta (including the Calgary Health Region) and maintains a computerized database of all dialysis patients, kidney transplant patients, and patients who have CKD and are followed in the MDC clinic (21). Renal transplant recipients and patients who already were receiving dialysis at study entry were excluded.

The cohort also was linked to provincial administrative data (as described previously) (22,23) to obtain information on prescription drug use in the year before their index GFR. Briefly, all residents of Alberta who are 65 yr and older receive insured health services, including coverage for prescription drugs. For ensuring availability of 1 yr of drug data for all patients, entry into the study was limited to patients who were 66 yr and older. In addition to determining exposure to specific classes of medications (including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β blockers, diuretics, nonsteroidal anti-inflammatory drugs, and cholesterol-lowering drugs), drug data were used to determine the presence of diabetes, as defined by at least one prescription for insulin or an oral hypoglycemic agent in the year before the index GFR, and to derive a measure of comorbidity (24).

Assessment of Kidney Function

An estimate of GFR was obtained from the Modification of Diet in Renal Disease (MDRD) equation, using variables for age, gender, and serum creatinine (25). Preliminary studies have validated this equation in the elderly population (26). Although data on race were not available from the data sources, fewer than 1% of the Alberta population is black (27); therefore, the impact at the population level of eliminating race from the estimate of GFR was expected to be minimal. We limited our study population to individuals with stage 3 or greater CKD (index GFR <60 ml/min per 1.73 m2).

Multidisciplinary Care Clinics

Patients are referred to the MDC clinic by their primary nephrologist. At the first MDC visit, an education session is held with the patient and his or her family members and is attended by a specialized clinic nurse, registered dietician, and social worker. Patient education includes a discussion of CKD and its progression and complications, fluid and dietary restrictions, monitoring BP, effects of medications, and recommendations regarding exercise and diet. Patients also are provided with a booklet produced by the Kidney Foundation (“Living with Kidney Disease,” available at http://www.kidney.ca/files/Kidney/aCompleteManual.pdf). MDC patients undergo blood work every 1 to 3 mo to monitor kidney function and metabolic complications and are seen by their primary nephrologist every 3 to 6 mo. Management in the MDC clinic is focused on medical management and lifestyle modification to delay progression of CKD and target cardiovascular risk factor reduction.

Study Outcome

All-cause mortality, obtained from the Alberta Bureau of Vital Statistics, was the primary outcome. Secondary outcomes included hospitalization (all-cause) and hospitalization for cardiovascular causes (composite of acute myocardial infarction [AMI], congestive heart failure [CHF], cerebrovascular accident [CVA], or transient ischemic attack [TIA], as determined from the Calgary Health Region corporate database. For patients with multiple hospitalizations, only the first hospitalization during the study period was included. Cause-specific hospitalizations were based on the following validated codes from the International Classification of Diseases Ninth and Tenth Revisions, using the primary discharge diagnosis: AMI (28,29) 410, 411.1, I21, or I22; CHF (30,31) 428 or I50; and CVA/TIA (32) 362.3, 433.x1, 434.x1, 436, 431.x, 430.x, 435.x, H34.1, I63.x, I64.x, I61.x, I60.x, or G45.x.

Statistical Analyses

Characteristics for MDC and non-MDC patients (the remaining patients in the cohort) were compared with χ2 tests for categorical variables, t test for age, and rank-sum test for the comorbidity score. For the survival analysis, all patients were followed from the date of their index GFR until death or the end of the study (December 31, 2004). Because MDC and non-MDC patients may have different characteristics, we used a propensity score analysis (33) to adjust for differences in the likelihood of being followed in an MDC clinic between the two groups. A propensity score analysis is a method of controlling for confounding in observational studies.

The first step in the propensity score analyses was to calculate an individual’s propensity score, which is defined as his or her conditional probability of assignment to the MDC group, given the observed confounders. To obtain this propensity score, we used logistic regression to model the likelihood of MDC as the dependent variable, with independent variables including age, gender, index GFR, diabetes, comorbidity score, and medication use including angiotensin-converting enzyme inhibitor or angiotensin receptor blockers, β blockers, calcium channel blockers, antiarrhythmics, diuretics, cholesterol-lowering agents, and nonsteroidal anti-inflammatory drugs. The predicted probability of the dependent variable (likelihood of MDC) from this model represents the propensity score for each individual and provides an estimate of the probability that an individual was followed at the MDC clinic. The area under the receiver operating characteristic (ROC) curve was calculated to assess the predictive ability of the propensity score model.

MDC and non-MDC patients then were matched using Greedy matching algorithms, on the basis of their propensity score, at a ratio of 1:1. Matching on the propensity score allowed comparison of survival and hospitalization outcomes for individuals with a similar likelihood of being referred and followed in an MDC clinic. One-to-one matching was chosen on the basis of assessment of model fit and a more balanced distribution of patient characteristics and propensity scores after matching. Survival at up to 3.5 yr was calculated for the MDC and non-MDC groups. Kaplan-Meier survival curves were plotted for the two groups, with differences in survival compared using the log rank test.

The association between MDC and survival was characterized further using Cox models and shared frailty modeling techniques, which take into account the matching of patients (34). Covariates that were considered in the model included age, gender, diabetes, baseline GFR, and comorbidity score. We also conducted two sensitivity analyses for the mortality outcome: (1) On a subgroup of patients for whom we had a measure of serum hemoglobin and albumin, to assess their potential confounding effect, and (2) on a subgroup of patients who were in the MDC clinic between July 1, 2001, and December 31, 2001 (the same period that was used to define the non-MDC group), to assess the potential for a survivor bias.

This analysis was repeated using time to all-cause hospitalization, as well as time to hospitalization for a cardiovascular cause, as the outcome. All analyses were conducted using SAS (version 9.1; SAS Institute, Cary, NC) and STATA (version 9.0; STATA Corp., College Station, TX). The conjoint ethics review board at the University of Calgary approved the study.

Results

A total of 6978 patients with CKD were included in the study, 187 (2.7%) of whom were followed in the MDC clinic. Baseline patient characteristics, by MDC status, are shown in Table 1. Compared with non-MDC patients, patients in the MDC clinic were younger and more likely to be male, have a lower GFR, and have increased comorbidity. During the study period, 61 (32.6%) patients in the MDC group died, compared with 1874 (27.6%) in the non-MDC group (P = 0.13). Patients in the MDC group also were more likely to initiate dialysis during the study period (43.4 versus 1.5%; P < 0.0001).

View this table:
Table 1.

Baseline patient characteristics by MDC, before matchinga

Propensity Score Analysis

The logistic regression model to derive the propensity score, using likelihood of being followed in the MDC clinic as the outcome, had an area under the ROC curve of 0.93, denoting excellent predictive discrimination with respect to the outcome (a value of 1.0 indicates perfect predictive discrimination, whereas a value of 0.5 indicates no ability to discriminate with respect to the outcome). Each MDC patient then was matched at a ratio of 1:1 to a non-MDC patient, on the basis of their propensity score. Baseline characteristics of the MDC and non-MDC group were similar after matching (Table 2). All remaining analyses are based on the 187 MDC patients and the matched 187 non-MDC patients.

View this table:
Table 2.

Baseline patient characteristics by MDC, after matching 1:1 on propensity score

All-Cause Mortality

Of the 374 patients in the matched analyses, 61 (32.6%) in the MDC and 77 (41.2%) in the non-MDC group died during the study period. As shown in Figure 1, Kaplan-Meier survival estimates demonstrated a significant increased likelihood of survival for MDC compared with non-MDC patients (log rank test P = 0.008). In the unadjusted Cox regression analysis, MDC care was associated with a 44% reduction in the risk for death compared with non-MDC care (hazards ratio [HR] 0.56; 95% confidence interval [CI] 0.40 to 0.79). After adjustment for age, gender, baseline GFR, diabetes, and comorbidity score, there was a 50% reduction in the risk for death for the MDC group compared with the non-MDC group (HR 0.50; 95% CI 0.35 to 0.71).

Figure 1.
Figure 1.

Kaplan-Meier plot of patient survival over time, by multidisciplinary care.

The mortality results were unchanged after adjustment for the potential confounding effects of serum hemoglobin and albumin. In the analyses that were limited to patients who were present in the MDC clinic between July 1 and December 31, 2001 (n = 105), a trend for a mortality benefit was observed (HR 0.69; 95% CI 0.44 to 1.06).

Hospitalizations

A total of 123 (65.8%) patients in the MDC and 131 (70.1%) in the non-MDC group had at least one hospitalization during the study period. There was no difference in the risk for hospitalization for the MDC compared with the non-MDC group (log rank test P = 0.18; Figure 2). In the Cox regression analysis using a frailty model and after adjustment for age, gender, baseline GFR, diabetes, and comorbidity, there was a nonsignificant 17% reduction in the risk for hospitalization for MDC compared with non-MDC care (HR 0.83; 95% CI 0.64 to 1.06).

Figure 2.
Figure 2.

Kaplan-Meier plot of time to first all-cause hospitalization, by multidisciplinary care.

There was no difference in the risk for hospitalization for the composite outcome of AMI/CHF/CVA/TIA for the MDC compared with the non-MDC group (long rank test P = 0.12; Figure 3). In the Cox regression analysis, adjusting for the variables as listed above, MDC care was associated with a nonsignificant reduction in the risk for hospitalization for this composite outcome (HR 0.76; 95% CI 0.54 to 1.06).

Figure 3.
Figure 3.

Kaplan-Meier plot of time to first hospitalization for the composite outcome of acute myocardial infarction/congestive heart failure/cerebrovascular accident/transient ischemic attack (AMI/CHF/CVA/TIA), by multidisciplinary care.

Discussion

The benefits of early referral to nephrology care in reducing adverse outcomes are well documented (35–37); however, the impact of including a multidisciplinary team in the delivery of this care is less well established. Given the complexity of care that is required to treat patients with CKD (38), there are theoretical benefits to a coordinated multidisciplinary approach. This is particularly relevant because current evidence suggests that even timely nephrology care in this patient group may not result in optimal care (39–41). In this community-based study of elderly patients with CKD, we found a significantly lower risk for all-cause mortality for patients who were followed in the MDC clinic, although no significant difference in the risk for all-cause hospitalization and cardiovascular-specific hospitalization was evident.

The majority of previous observational studies that evaluated MDC did suggest a benefit of MDC in improving patient survival, although these studies were limited to patients who initiated dialysis (10,11,42). Given that patients with stage 4 CKD are more than twice as likely to die as to develop ESRD (43), a survival bias may have influenced these results. John et al. (44) were some of the few investigators who were able to identify a community-based cohort of patients with CKD. Although a two-fold increase in mortality was reported for patients with no renal care, it is unclear whether renal services included MDC or nephrologists’ care alone.

One of the few randomized trials that evaluated MDC in patients with CKD found no effect of MDC compared with usual care on outcomes, including decline in kidney function, health care utilization, and mortality (12). In addition to several other limitations, the investigators relied on primary care physicians to implement recommendations. Lack of adherence to recommendations may have biased the results toward the null. A more recent randomized trial of 200 patients with CKD (13) compared the impact of a physician-supervised, nurse-driven multiple risk factor intervention clinic with conventional care on biochemical and surrogate measures of vascular structure and function. Although the specialized clinic achieved better control of LDL cholesterol, homocysteine, and BP, no difference between the two groups was observed for the outcomes of carotid intima-media thickness or brachial artery reactivity. Although these results suggest limited benefit associated with CKD MDC, it is possible that benefits in atheroma burden or vascular function were not observed because the intervention was too late (approximately 60% of patients were already on dialysis), the study sample was underpowered after dropouts, or one or more specific elements that were chosen for the intervention were, in retrospect, incorrect (e.g., lowering of homocysteine [45,46]). In contrast to the lack of an effect of MDC in randomized trials of patients with CKD, provision of MDC with a focus on multifactorial risk factor interventions has been shown to improve morbidity and mortality outcomes in other chronic disease states, including diabetes (16), congestive heart failure (18–20), and rheumatoid arthritis (17).

There are several possible explanations for the all-cause survival benefits in the MDC group that developed early and persisted beyond 1 yr. Management in the MDC clinic is focused on medical management and lifestyle modification to delay CKD progression and target cardiovascular risk factor reduction. Although not directly measured, it also is plausible that dietary advice and lifestyle modification of hyperkalemia, a common complication of CKD, affected survival. Other interventions that are common in the MDC and also have significant short-term survival benefits include use of statins (47) and smoking cessation (48,49).

Although our study suggests that MDC is associated with a survival benefit, these results should be interpreted within the context of the study’s limitations. First, we were unable to determine the specific elements in the MDC clinic that may have affected survival. MDC for the patient with heart failure suggests that three elements are crucial to the success of the program: Specially trained nurses, education of patients and their families, and access to clinicians who are specially trained in the area (18). A noncontemporary, randomized, controlled trial in patients with advanced kidney disease demonstrated an extension in time to initiation of renal replacement therapy and improved survival with a single psychoeducational intervention (14,15). Whether the educational element, independent of the trained nurses or related elements, was important in improving survival in our study is not possible to determine. Second, the use of laboratory data to define the study cohort limited the study to patients who sought medical care and had at least one outpatient serum creatinine measurement. Because the study sample was based on the elderly, who are more likely to use the health care system and have laboratory testing performed, this is unlikely to bias substantially the study results. Misclassification of CKD also is unlikely, because the majority (86.7%) of patients had stage 4 CKD. Data from a cohort that is identified by laboratory-based case finding also are generalized easily to primary care practice. Third, as with all observational studies, the possibility of residual confounding cannot be excluded. Although we adjusted for comorbidity on the basis of medication use, this may underestimate the true prevalence of these conditions. We also were unable to adjust for other aspects of care, including BP control, medication use, and progression of kidney disease, which may influence the results. However, the use of the propensity score analysis, with matching of MDC and non-MDC patients on the basis of their likelihood of being followed in the MDC clinic, should reduce the potential for such bias. In addition, the results of the logistic regression model to derive the propensity score (with an area under the ROC curve of 0.93) suggest excellent predictive discriminatory ability for the outcome. Fourth, the manner in which the patients were chosen may have introduced a survivor bias. Although this requires a more valid assessment in a randomized, controlled trial, our conservative sensitivity analysis did suggest a persistent benefit of MDC clinics that may have been statistically significant with a larger sample size. Finally, our results are based on the experience within a single center. However, given the similarity of MDC clinics nationally (9), there is no reason to believe that these results could not be generalized to other centers.

Conclusion

We found that compared with usual care, MDC for elderly patients with CKD was associated with improved survival. Although definitive determination of the effectiveness of MDC in improving health outcomes remains to be confirmed from a randomized clinical trial (Canadian Prevention of Renal and Cardiovascular Endpoints Trial [CANPREVENT]) (50), our results suggest that clinicians and decision makers should continue to support MDC to optimize health outcomes for patients with CKD.

Disclosures

None.

Acknowledgments

This study was funded by the Kidney Foundation of Canada. B.R.H., B.J.M., and M.T. are supported by New Investigator Awards from the Canadian Institutes of Health Research. B.R.H. and M.T. also are supported by Population Health Investigator Awards from the Alberta Heritage Foundation for Medical Research, and S.K. is supported by a Biomedical Scholarship from the Kidney Foundation of Canada.

Footnotes

  • Published online ahead of print. Publication date available at www.jasn.org.

References

  1. ↵
    Manjunath G, Tighiouart H, Coresh J, Macleod B, Salem DN, Griffith JL, Levey AS, Sarnak MJ: Level of kidney function as a risk factor for cardiovascular outcomes in the elderly. Kidney Int 63 : 1121 –1129, 2003
    OpenUrlCrossRefPubMed
  2. Shlipak MG, Fried LF, Stehman-Breen C, Siscovick D, Newman AB: Chronic renal insufficiency and cardiovascular events in the elderly: Findings from the Cardiovascular Health Study. Am J Geriatr Cardiol 13 : 81 –90, 2004
    OpenUrlCrossRefPubMed
  3. Fried LF, Shlipak MG, Crump C, Bleyer AJ, Gottdiener JS, Kronmal RA, Kuller LH, Newman AB: Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals. J Am Coll Cardiol 41 : 1364 –1372, 2003
    OpenUrlCrossRefPubMed
  4. Mann JF, Gerstein HC, Pogue J, Bosch J, Yusuf S: Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: The HOPE randomized trial. Ann Intern Med 134 : 629 –636, 2001
    OpenUrlCrossRefPubMed
  5. ↵
    Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351 : 1296 –1305, 2004
    OpenUrlCrossRefPubMed
  6. ↵
    Levin A: The need for optimal and coordinated management of CKD. Kidney Int Suppl 99 : S7 –S10, 2005
  7. Barrett BJ: Applying multiple interventions in chronic kidney disease. Semin Dial 16 : 157 –164, 2003
    OpenUrlCrossRefPubMed
  8. ↵
    Mendelssohn DC: Coping with the CKD epidemic: The promise of multidisciplinary team-based care. Nephrol Dial Transplant 20 : 10 –12, 2005
    OpenUrlCrossRefPubMed
  9. ↵
    Mendelssohn DC, Toffelmire EB, Levin A: Attitudes of Canadian nephrologists toward multidisciplinary team-based CKD clinic care. Am J Kidney Dis 47 : 277 –284, 2006
    OpenUrlCrossRefPubMed
  10. ↵
    Curtis BM, Ravani P, Malberti F, Kennett F, Taylor PA, Djurdjev O, Levin A: The short- and long-term impact of multi-disciplinary clinics in addition to standard nephrology care on patient outcomes. Nephrol Dial Transplant 20 : 147 –154, 2005
    OpenUrlCrossRefPubMed
  11. ↵
    Goldstein M, Yassa T, Dacouris N, McFarlane P: Multidisciplinary predialysis care and morbidity and mortality of patients on dialysis. Am J Kidney Dis 44 : 706 –714, 2004
    OpenUrlCrossRefPubMed
  12. ↵
    Harris LE, Luft FC, Rudy DW, Kesterson JG, Tierney WM: Effects of multidisciplinary case management in patients with chronic renal insufficiency. Am J Med 105 : 464 –471, 1998
    OpenUrlCrossRefPubMed
  13. ↵
    Isbel NM, Haluska B, Johnson DW, Beller E, Hawley C, Marwick TH: Increased targeting of cardiovascular risk factors in patients with chronic kidney disease does not improve atheroma burden or cardiovascular function. Am Heart J 151 : 745 –753, 2006
    OpenUrlCrossRefPubMed
  14. ↵
    Devins GM, Mendelssohn DC, Barre PE, Binik YM: Predialysis psychoeducational intervention and coping styles influence time to dialysis in chronic kidney disease. Am J Kidney Dis 42 : 693 –703, 2003
    OpenUrlCrossRefPubMed
  15. ↵
    Devins GM, Mendelssohn DC, Barre PE, Taub K, Binik YM: Predialysis psychoeducational intervention extends survival in CKD: A 20-year follow-up. Am J Kidney Dis 46 : 1088 –1098, 2005
    OpenUrlCrossRefPubMed
  16. ↵
    Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 348 : 383 –393, 2003
    OpenUrlCrossRefPubMed
  17. ↵
    Vliet Vlieland TP, Breedveld FC, Hazes JM: The two-year follow-up of a randomized comparison of in-patient multidisciplinary team care and routine out-patient care for active rheumatoid arthritis. Br J Rheumatol 36 : 82 –85, 1997
    OpenUrlCrossRefPubMed
  18. ↵
    McAlister FA, Stewart S, Ferrua S, McMurray JJ: Multidisciplinary strategies for the management of heart failure patients at high risk for admission: A systematic review of randomized trials. J Am Coll Cardiol 44 : 810 –819, 2004
    OpenUrlCrossRefPubMed
  19. Ducharme A, Doyon O, White M, Rouleau JL, Brophy JM: Impact of care at a multidisciplinary congestive heart failure clinic: A randomized trial. CMAJ 173 : 40 –45, 2005
    OpenUrlAbstract/FREE Full Text
  20. ↵
    Holland R, Battersby J, Harvey I, Lenaghan E, Smith J, Hay L: Systematic review of multidisciplinary interventions in heart failure. Heart 91 : 899 –906, 2005
    OpenUrlAbstract/FREE Full Text
  21. ↵
    Manns BJ, Mortis GP, Taub KJ, McLaughlin K, Donaldson C, Ghali WA: The Southern Alberta Renal Program database: A prototype for patient management and research initiatives. Clin Invest Med 24 : 164 –170, 2001
    OpenUrlPubMed
  22. ↵
    Hemmelgarn BR, Zhang J, Manns BJ, Tonelli M, Larsen E, Ghali WA, Southern DA, McLaughlin K, Mortis G, Culleton BF: Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int 69 : 2155 –2161, 2006
    OpenUrlCrossRefPubMed
  23. ↵
    Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S, Hemmelgarn BR: Impact of anemia on hospitalization and mortality in older adults. Blood 107 : 3841 –3846, 2006
    OpenUrlAbstract/FREE Full Text
  24. ↵
    Clark DO, Von Korff M, Saunders K, Baluch WM, Simon GE: A chronic disease score with empirically derived weights. Med Care 33 : 783 –795, 1995
    OpenUrlCrossRefPubMed
  25. ↵
    Levey AS, Greene T, Kusek JW, Beck GJ: A simplified equation to predict glomerular filtration rate from serum creatinine [Abstract]. J Am Soc Nephrol 11 : 155A , 2000
    OpenUrl
  26. ↵
    Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P: Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 16 : 763 –773, 2005
    OpenUrlAbstract/FREE Full Text
  27. ↵
    Census Canada: 1996 Canadian Census Directory, Ottawa, Census Canada, 1996
  28. ↵
    Tu JV, Naylor CD, Austin P: Temporal changes in the outcomes of acute myocardial infarction in Ontario, 1992–1996. CMAJ 161 : 1257 –1261, 1999
    OpenUrlAbstract/FREE Full Text
  29. ↵
    Chang WC, Kaul P, Westerhout CM, Graham MM, Fu Y, Chowdhury T, Armstrong PW: Impact of sex on long-term mortality from acute myocardial infarction vs unstable angina. Arch Intern Med 163 : 2476 –2484, 2003
    OpenUrlCrossRefPubMed
  30. ↵
    Sin DD, McAlister FA: The effects of beta-blockers on morbidity and mortality in a population-based cohort of 11,942 elderly patients with heart failure. Am J Med 113 : 650 –656, 2002
    OpenUrlCrossRefPubMed
  31. ↵
    Ezekowitz JA, van Walraven C, McAlister FA, Armstrong PW, Kaul P: Impact of specialist follow-up in outpatients with congestive heart failure. CMAJ 172 : 189 –194, 2005
    OpenUrlAbstract/FREE Full Text
  32. ↵
    Kokotailo RA, Hill MD: Coding of stroke and stroke risk factors using international classification of diseases, revisions 9 and 10. Stroke 36 : 1776 –1781, 2005
    OpenUrlAbstract/FREE Full Text
  33. ↵
    Rubin DB: Estimating causal effects from large data sets using propensity scores. Ann Intern Med 127 : 757 –763, 1997
    OpenUrlCrossRefPubMed
  34. ↵
    Hougaard P: Frailty models for survival data. Lifetime Data Anal 1 : 255 –273, 1995
    OpenUrlCrossRefPubMed
  35. ↵
    Kazmi WH, Obrador GT, Khan SS, Pereira BJ, Kausz AT: Late nephrology referral and mortality among patients with end-stage renal disease: A propensity score analysis. Nephrol Dial Transplant 19 : 1808 –1814, 2004
    OpenUrlCrossRefPubMed
  36. Khan SS, Xue JL, Kazmi WH, Gilbertson DT, Obrador GT, Pereira BJ, Collins AJ: Does predialysis nephrology care influence patient survival after initiation of dialysis? Kidney Int 67 : 1038 –1046, 2005
    OpenUrlCrossRefPubMed
  37. ↵
    Kinchen KS, Sadler J, Fink N, Brookmeyer R, Klag MJ, Levey AS, Powe NR: The timing of specialist evaluation in chronic kidney disease and mortality. Ann Intern Med 137 : 479 –486, 2002
    OpenUrlCrossRefPubMed
  38. ↵
    K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease. Am J Kidney Dis 43[Suppl 1] : S1 –S290, 2004
    OpenUrl
  39. ↵
    Tonelli M, Bohm C, Pandeya S, Gill J, Levin A, Kiberd BA: Cardiac risk factors and the use of cardioprotective medications in patients with chronic renal insufficiency. Am J Kidney Dis 37 : 484 –489, 2001
    OpenUrlCrossRefPubMed
  40. Nissenson AR, Collins AJ, Hurley J, Petersen H, Pereira BJ, Steinberg EP: Opportunities for improving the care of patients with chronic renal insufficiency: Current practice patterns. J Am Soc Nephrol 12 : 1713 –1720, 2001
    OpenUrlAbstract/FREE Full Text
  41. ↵
    London R, Solis A, Goldberg GA, Wade S, Ryu S: Health care resource utilization and the impact of anemia management in patients with chronic kidney disease. Am J Kidney Dis 40 : 539 –548, 2002
    OpenUrlCrossRefPubMed
  42. ↵
    Ravani P, Marinangeli G, Tancredi M, Malberti F: Multidisciplinary chronic kidney disease management improves survival on dialysis. J Nephrol 16 : 870 –877, 2003
    OpenUrlPubMed
  43. ↵
    Keith DS, Nichols GA, Gullion CM, Brown JB, Smith DH: Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164 : 659 –663, 2004
    OpenUrlCrossRefPubMed
  44. ↵
    John R, Webb M, Young A, Stevens PE: Unreferred chronic kidney disease: A longitudinal study. Am J Kidney Dis 43 : 825 –835, 2004
    OpenUrlCrossRefPubMed
  45. ↵
    Zoungas S, McGrath BP, Branley P, Kerr PG, Muske C, Wolfe R, Atkins RC, Nicholls K, Fraenkel M, Hutchison BG, Walker R, McNeil JJ: Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: A multicenter, randomized, controlled trial. J Am Coll Cardiol 47 : 1108 –1116, 2006
    OpenUrlCrossRefPubMed
  46. ↵
    Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, Wang H, Nordrehaug JE, Arnesen E, Rasmussen K: Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354 : 1578 –1588, 2006
    OpenUrlCrossRefPubMed
  47. ↵
    Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 333 : 1301 –1307, 1995
    OpenUrlCrossRefPubMed
  48. ↵
    US Department of Health and Human Services: The Health Benefits of Smoking Cessation. A Report of the Surgeon General [90-8416], Washington, DC, DHHS, 1990
  49. ↵
    Wilhelmsson C, Vedin JA, Elmfeldt D, Tibblin G, Wilhelmsen L: Smoking and myocardial infarction. Lancet 1 : 415 –420, 1975
    OpenUrlCrossRefPubMed
  50. ↵
    Parfrey P, Barrett B, Levin A, Churchill D, Goeree R, Singer J, Molzahn A, Djurdjev O: The Canadian Prevention of Renal and Cardiovascular Endpoints Trial, 2006. Available at: http://clinicaltrials.gov. Accessed August 10, 2006
Back to top

In this issue

View Selected Citations (0)
Print
Download PDF
Email Article
Citation Tools
Request Permissions
Association between Multidisciplinary Care and Survival for Elderly Patients with Chronic Kidney Disease
Brenda R. Hemmelgarn, Braden J. Manns, Jianguo Zhang, Marcello Tonelli, Scott Klarenbach, Michael Walsh, Bruce F. Culleton
JASN Mar 2007, 18 (3) 993-999; DOI: 10.1681/ASN.2006080860
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Jump to section

More in this TOC Section

Cited By...

Similar Articles

Related Articles

  • No related articles found.