Chronic Kidney Disease

Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness: The Hoorn Study

Marc M.H. Hermans, Ronald Henry, Jacqueline M. Dekker, Jeroen P. Kooman, Piet J. Kostense, Giel Nijpels, Robert J. Heine and Coen D.A. Stehouwer
JASN June 2007, 18 (6) 1942-1952; DOI: https://doi.org/10.1681/ASN.2006111217

Abstract

Mild renal insufficiency is a risk factor for cardiovascular disease (CVD). Both a decline in GFR and (micro)albuminuria are associated with greater cardiovascular mortality. In ESRD, arterial stiffness, an important cause of CVD, is known to be greater, but few data exist in individuals with mild renal insufficiency or microalbuminuria. This study investigated the association of impaired renal function expressed as lower GFR or greater urinary albumin excretion with arterial stiffness. In a population-based study in 806 individuals (402 men), mean age 68 yr (range 50 to 87), peripheral arterial stiffness (by compliance and distensibility of the carotid, brachial, and femoral arteries and by the carotid elastic modulus [Einc]) and central arterial stiffness (by total systemic arterial compliance, carotid-femoral transit time, and aortic augmentation index) were measured ultrasonically. GFR was estimated (eGFR) by the Modification of Diet in Renal Disease (MDRD) formula. Urinary albumin excretion was expressed as urinary albumin/creatinine ratio (UACR). eGFR was 60.6 ± 11.1 ml/min per 1.73 m2. Median UACR was 0.57 mg/mmol (range 0.1 to 26.6). After adjustment for age, mean arterial pressure (MAP), gender, and glucose tolerance status (GTS), each 5-ml/min per 1.73 m2 lower eGFR was associated with a lower distensibility coefficient of the carotid (regression coefficient β −0.20 10−3/kPa; 95% confidence interval [CI] −0.34 to −0.07 10−3/kPa) and brachial artery (−0.15 10−3/kPa; 95% CI −0.28 to −0.03 10−3/kPa) and a greater carotid Einc (0.02 kPa; 95% CI 0.0004 to 0.04 kPa). No statistically significant association was found of eGFR with other arterial stiffness indices. After adjustment for age, MAP, gender, and GTS, a greater UACR (per quartile) was associated with a greater Einc (0.03 kPa; 95% CI 0.001 to 0.07 kPa) and a trend to a lower distensibility coefficient (−0.24 10−3/kPa; 95% CI −0.49 to 0.02 10−3/kPa) of the carotid artery. After adjustment for age, MAP, gender, and GTS, a greater UACR (per quartile) was in addition associated with a shorter carotid-femoral transit time (−1.67 ms; 95% CI −3.24 to −0.10 ms). These associations were not substantially changed by mutual adjustment for eGFR and UACR. In individuals with mild renal insufficiency, both a lower eGFR and a greater albumin excretion, even below levels that are considered to reflect microalbuminuria, are independently associated with greater arterial stiffness. Moreover, these associations were mutually independent. These findings may explain, in part, why eGFR and microalbuminuria are associated with greater risk for CVD and suggest that amelioration of arterial stiffness could be a target of intervention.

Chronic kidney disease (CKD) is defined as a lowering of the GFR and/or the presence of (micro)albuminuria (1). In severe CKD (ESRD), cardiovascular mortality is greatly increased (2). Mild renal insufficiency has also been associated with a greater cardiovascular mortality (3,4). In addition, (micro)albuminuria has been associated with an increase in cardiovascular disease (CVD) and mortality in a wide variety of populations (5–7). The underlying mechanisms are incompletely understood. Increased arterial stiffness is a widely known process in severe CKD (8–10) and has been associated with greater cardiovascular mortality (11,12).

We hypothesized that arterial stiffness may be increased in mild renal insufficiency (stages 2 to 3 CKD [1]) and in individuals with (micro)albuminuria and that this may be one of the mechanisms that link these conditions to CVD. To test this hypothesis, we investigated, in a population-based study of 806 individuals, the association between GFR (estimated by the Modification of Diet in Renal Disease [MDRD] formula [13]) and arterial stiffness. In addition, we investigated the association between urinary albumin excretion (UAE) and arterial stiffness and whether these associations were mutually independent.

Materials and Methods

Study Population

For this cross-sectional investigation, we used data from the 2000 Hoorn Study follow-up examination and the Hoorn Screening Study. Details have been described elsewhere (14,15). Briefly, the Hoorn Study is a cohort study of glucose tolerance and CVD in the general population. The Hoorn Screening Study is a population-based targeted type 2 diabetes screening study. The local ethics committee approved the studies, and written informed consent was obtained from all participants. Each participant underwent an oral glucose tolerance test, except those with previously diagnosed diabetes, and glucose tolerance status (GTS) was classified according to the 1999 World Health Organization criteria (16). The final study population consisted of 806 individuals (299 with normal glucose metabolism, 181 with impaired glucose metabolism, and 326 with type 2 diabetes).

Estimates of Renal Function

Renal function was estimated by the MDRD formula in ml/min per 1.73 m2: 170 × creatinine−0.999 × age−0.176 × urea−0.170 × albumin0.318 × 0.762 if female (all participants where white). Because of missing laboratory values, estimated GFR (eGFR) could not be determined in 31 cases. Urinary albumin-creatinine ratio (UACR) in mg/mmol was determined in an overnight first-voided urine sample. Microalbuminuria was defined as a UACR between 2 and 30 mg/mmol. Urinary albumin was measured by rate nephelometry (Array Protein System; Beckman Coulter, Fullerton, CA) with an assay threshold of 2 mg/L. Urinary and serum creatinine was measured by a modified Jaffé test. Patients with macroalbuminuria (>30 mg/mmol; n = 8) were excluded from further analysis. To include patients (n = 86) with an albuminuria level below the assay threshold, a UACR was calculated with albumin concentration set at 1.9 mg/L divided by the urinary creatinine concentration. Formulas are given in traditional units. To convert to International System units, multiply creatinine in mg/dl by 88.4, urea in mg/dl by 0.357, and albumin in g/dl by 10.

BP Measurement

Brachial artery (BA) systolic (SBP) and diastolic BP (DBP) were assessed in the left upper arm at 5-min intervals with an oscillometric device (Colin Press-Mate BP-8800, Colin Medical Instruments, San Antonio, TX), as described previously (17). Brachial pulse pressure (PP) was calculated as systolic minus DBP and brachial mean arterial pressure (MAP) as (2 × DBP + SBP)/3. PP at the carotid (CCA) and femoral artery (FA) was calculated according to the calibration method described by Kelly and Fitchett (18), with use of distension waveforms as adapted from Van Bortel et al. (19). This method assumes a constant difference between MAP and DBP along the arterial tree. PP can be calculated at a target artery (PPtar) from the PP at a reference artery (PPref) and a calibration factor (K) at target and reference arteries (Ktar and Kref) by the formula PPtar = PPref × Ktar/Kref, in which K is defined as (MAP − DBP)/PP, and (MAP − DBP) can be calculated from the area under the pressure curve divided by time (18,19).

Arterial Properties

Diameter, Distension, and Intima-Media Thickness.

Details have been described elsewhere (17). Briefly, a single observer who was unaware of the participants’ clinical or glucose tolerance status obtained properties of the right CCA, FA, and BA, with the use of an ultrasound scanner (350 Series, 7.5-MHz probe; Pie Medical, Maastricht, The Netherlands). The scanner was connected to a PC equipped with vessel wall movement detection software (Wall Track System; Pie Medical). Data were obtained from three consecutive measurements. Diastolic diameter was calculated as the difference between the anterior and posterior wall markers. The change of diameter as a function of time (distension) was estimated and presented on the computer screen (distension waveform). In addition, the carotid posterior wall thickness was calculated. The mean diameter, distension, and intima-media thickness (IMT) were used in analysis.

Peripheral Arterial Stiffness: Distensibility, Compliance, and Young’s Elastic Modulus.

We calculated CCA, BA, and FA distensibility and compliance coefficients as follows (20):

Distensibility coefficient = (2ΔD × D + ΔD2)/(ΔP × D2) in 10−3/kPa

Compliance coefficient = π(2D × ΔD + ΔD2)/(4 × ΔP) in mm2/kPa

where ΔD is distension, D is diameter, and ΔP is PP.

The distensibility coefficient reflects the elastic properties, whereas the compliance coefficient reflects the buffering capacity. From IMT, diameter, and carotid distensibility, we calculated Young’s elastic modulus (Einc), an indicator of the intrinsic wall properties:

Einc = diameter/(IMT × distensibility coefficient) in kPa

Central Arterial Stiffness: Carotid-Femoral Transit Time, Aortic Augmentation Index, and Total Systemic Arterial Compliance.

Carotid-femoral transit time (CFTT), which is a measure of aortic (thoracic-abdominal) compliance, was measured as described elsewhere (17,21). Briefly, CFTT is the travel time of a pressure wave from the CCA to the FA, and it is an approximation of the pulse wave velocity (PWV) (22). We determined the CFTT by continuous measurement of the diameter (distension curves) of the right CCA and FA. We then determined the average time delay (mean of three recordings) from the electrocardiograph trigger to 10% of the ascending slope of the distension curve of both arteries and subtracted the carotid value from the femoral value to obtain the CFTT. We did not measure the carotid-femoral distance noninvasively because this might induce error in obese and older patients (tortuous aorta). Instead of measuring the carotid-femoral distance, we adjusted for height in statistical analysis. Reproducibility of the CFTT has been reported (23).

The aortic augmentation index (aAIX) represents the additional load to which the left ventricle is subjected as a result of the timing of wave reflection. In addition, the aAIX depends on the heart rate amplitude and location of the reflection sites and is a less pure estimate of arterial stiffness (24). We used radial applanation tonometry performed with a Millar piezoresistive pressure transducer connected to an arterial wave form analysis device (Sphygmocor, Moreton-in-the-Marsh, UK) (25) to obtain the aAIX and aortic PP. The aAIX was calculated as augmented pressure divided by (tonometrically derived) central PP.

Total systemic arterial compliance (ml/mmHg) was determined according to the ratio of stroke volume to aortic PP (26). This method used the ratio of stroke volume to aortic PP (ml/mmHg) to determine total systemic arterial compliance, for which stroke volume was calculated as cardiac output divided by heart rate, and aortic PP was calculated by use of a calibration method (vide supra). This method multiplies the difficulty in accurately determining stroke volume and PP at the ascending aorta noninvasively (27), which means that these data should be interpreted with caution.

Reproducibility.

Reproducibility of the aforementioned methods have been reported (17,25).

Statistical Analyses

All analyses were carried out with SPSS. Multiple linear regression analysis was used to investigate the associations between renal function estimates and arterial properties. All associations were first analyzed without adjustments and then with adjustments for potential confounders. Because the population was stratified according to age, gender, and GTS and arterial stiffness is affected by age, gender, GTS, and MAP (20,28), these variables were considered first in the adjusted models. We used brachial MAP for all adjustments because MAP is constant throughout the arterial tree (19). Diabetes is often accompanied with impaired renal function and arterial stiffness. Interaction terms were used to investigate whether the association between eGFR and UAE with arterial stiffness differed according to the presence of diabetes. Two sided P < 0.05 was considered statistically significant.

Results

Of the 806 participants, eGFR was missing in 31 cases and UACR in five cases. Seven patients were excluded because of macroalbuminuria (albuminuria >30 mg/mmol). The associations between eGFR and arterial stiffness were studied in the remaining 767 individuals, and the association between UACR and arterial stiffness was studied in 794 individuals. Qualitatively satisfactory examinations were obtained of 756 CCA, 689 BA, and 656 FA. The main reason for missing data was poor definition of the arterial wall attributable to obesity. Except for body mass index (BMI) the nonparticipants were comparable with the study population.

Baseline Characteristics

Tables 1 and 2 show the characteristics of the study population according to tertiles of eGFR and according to quartiles of UACR, respectively. eGFR ranged from 24 to 114 ml/min per 1.73 m2. Most individuals (n = 755) had mild to moderate CKD (stages 2 to 3). Three participants had severe (stage 4) CKD, and nine had stage 1 CKD (eGFR ≥90 ml/min per 1.73 m2 with microalbuminuria). Median UACR was 0.57 mg/mmol (range 0.1 to 26.6 mg/mmol).

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Table 1.

Baseline characteristics of the study population according to tertiles of eGFRa

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Table 2.

Baseline characteristics of the study population according to quartiles of UACRa

Arterial Properties According to eGFR

For the CCA, BA, and FA, a lower eGFR was associated with greater arterial diameter, PP, and carotid IMT, whereas associations with distension were NS. As a result, a lower eGFR was associated with lower distensibility coefficients and a greater carotid Einc, whereas associations with the compliance coefficients were NS (Table 3). Lower eGFR was not associated with central arterial stiffness.

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Table 3.

Arterial wall properties according to tertiles of eGFRa

After adjustment for age, MAP, gender, and GTS, a lower eGFR was inversely associated with CCA, BA, and FA distensibility (P = 0.002, P = 0.03, and P = 0.07, respectively) and carotid compliance (P = 0.09) and directly with carotid Einc (P = 0.04). These associations were not affected by further adjustment for UACR. The association with carotid Young’s elastic was NS after additional adjustment for BMI (Table 4).

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Table 4.

CCA, BA, and FA stiffness indices according to eGFR: Adjusted analysesa

Table 5 shows that the association between a lower eGFR and greater arterial stiffness of BA and FA was driven by associations with greater arterial diameter. The association with greater carotid Einc was driven by a smaller distension of the CCA.

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Table 5.

Associations of eGFR and arterial wall properties: Adjusted analysesa

Arterial Properties According to UAE Expressed as UACR

For the CCA, BA, and FA, a greater UACR was associated with a greater CCA and BA and a smaller FA diameter, with less CCA and FA and more BA distension, with greater PP in all three arteries, and with greater carotid IMT. As a result, a greater UACR was associated with less CCA and FA distensibility and compliance and with a greater carotid Einc (Table 6).

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Table 6.

Arterial wall properties according to quartiles of the UACRa

After adjustment for age, gender, GTS, and MAP, a greater UACR was associated with less CCA distensibility (P = 0.07) and with greater Einc (P = 0.04; Table 7). Further adjustment for eGFR, the presence of hypertension, or previous CVD slightly strengthened the associations with CCA distensibility and Einc (Table 7). Table 8 shows that the associations between UACR and CCA distensibility and Einc were driven mainly by the association with CCA diameter.

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Table 7.

Arterial stiffness indices according to quartiles of UACR: Adjusted analysesa

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Table 8.

Associations of UACR (in quartiles) and arterial wall properties: Adjusted analysesa

With regard to central arterial stiffness indices, a greater UACR was associated with a lower CFTT and total systemic arterial compliance and an increase in the aAIX (Table 6). After adjustment for age, gender, GTS, and MAP, associations between UACR and measures of central arterial stiffness were not statistically significant except for the association between UACR and CFTT. Age and MAP seemed to be the strongest confounders. Further adjustments for eGFR, hypertension, and previous CVD slightly weakened the association between UACR and CFTT (Table 9).

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Table 9.

Associations of UACR (in quartiles) and measures of central arterial stiffness: Adjusted analysesa

Additional Analyses

The results did not change materially after additional adjustments for total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol; use of lipid-lowering or anti-hypertensive drugs; or current smoking. With regard to the eGFR analyses, results also did not change after adjustment for previous CVD, diagnosis of hypertension, or waist-to-hip ratio. With regard to the UACR analyses, results did not change after additional adjustment for BMI or waist-to-hip ratio (data not shown). Exclusion of individuals with stage 1 (n = 9) and stage 4 CKD (n = 3) did not materially change the results. Furthermore, endothelial dysfunction is known to be related to arterial stiffness and to mortality in renal insufficiency (29,30); therefore, analyses were also adjusted for flow-mediated endothelium-dependent vasodilation of the BA. Also these adjustments did not materially change the results. Interaction analyses showed that the association between eGFR and UAE with arterial stiffness was not substantially influenced by the presence of diabetes.

Discussion

This population-based study had four main findings. First, in mild renal insufficiency (stages 2 to 3 CKD), a lower eGFR as estimated by the MDRD formula was associated with greater arterial stiffness. Second, a greater UAE, even below levels that are considered to indicate microalbuminuria, was associated with greater arterial stiffness. Third, lower eGFR and greater UAE were mutually independently associated with a greater arterial stiffness, suggesting that the mechanisms that link these variables to risk for CVD are at least in part independent of each other. Fourth, in contrast to a greater UAE, eGFR was not related to greater central arterial stiffness.

Our results with respect to the association of eGFR with arterial stiffness are partially in line with previous studies. Konings et al. (31) showed, in a small study, that the distensibility coefficient of the CCA was lower in patients with stages 2 to 4 CKD compared with control subjects. In contrast to our study, Mourad et al. (32) showed, in a population with mild renal insufficiency, a negative association between creatinine clearance and carotid-femoral PWV. Wang et al. (33) recently showed a greater aortic PWV in patients with stages 1 to 5 CKD. We, in agreement with a recently published study by Briet et al. (34), did not find an association of CFTT, an approximation of the PWV, with eGFR. Also in agreement with that study was our finding of an independent, negative relationship between eGFR and carotid Einc.

In general, with declining renal function, the distensibility of the arteries decreased, whereas the compliance coefficient remained largely unchanged. To a large extent, this phenomenon was explained by a greater arterial diameter in individuals with lower eGFR, which, for the BA and FA, was independent of MAP. It is not clear why there was no relation between eGFR and CCA diameter. In fact, Briet et al. (34) recently found an inverse relation between GFR and CCA internal diameter. The discrepancy with our results may be related to selective mortality in the Hoorn Study, because we previously showed that both a greater CCA diameter (35) and a lower eGFR (3,29) are related to increased mortality. A greater CCA diameter is thought to reflect so-called outward remodeling (36) and may be a defense mechanism to prevent loss of buffering capacity in case of a decrease in distensibility. The causes of a decrease in distensibility in mild renal insufficiency remain largely unclear. In animal models, renal insufficiency is associated with an accumulation of collagen instead of elastin in the aortic wall (37), and collagen represents the more rigid component of the arterial wall (10). Changes in water and salt balance (38), leading to renin-angiotensin-aldosterone system activation, may stimulate the collagen accumulation (39). Also other factors such as the accumulation of advanced glycosylation end products; the accumulation of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthesis; and oxidative stress may negatively influence the distensibility of the arterial wall (40,41).

We showed that greater UAE, even in a low-grade albuminuric range, was associated with a greater diameter and Einc of the CCA and a lower CFTT. In patients with type 1 diabetes, several authors have shown an association between microalbuminuria and greater CCA stiffness (42,43). Recently, Yokohama et al. (44) found in patients with type 2 diabetes that albuminuria was independently associated with carotid IMT. This was in line with the finding of Keech et al. (45), who showed in patients with type 2 diabetes that a greater UAE in the low-albuminuric range was independently associated with greater carotid IMT. However, in agreement with Kramer et al. (46), we did not find an association, either in the group as a whole or in the individuals with diabetes (n = 318) separately (data not shown). Our finding of an association between arterial stiffness and albumin excretion below the current microalbuminuria level is in agreement with studies that showed that the association between UAE and CVD starts at levels below microalbuminuria (7,47). Endothelial dysfunction and low-grade inflammation may be important mechanisms that link UAE with arterial stiffness and CVD (29,30), but it remains to be shown whether the association of UAE and arterial stiffness actually explains that between UAE and CVD.

The third major finding of our study was the mutual independence of the associations of eGFR and albuminuria with arterial stiffness. This suggests that both a decline in GFR and albuminuria, although they might share determinants such as hypertension and diabetes, could be independently associated with CVD in patients with CKD. Indeed, we recently showed that the association of eGFR with cardiovascular mortality is mostly independent of UAE (29).

A final finding of our study was that eGFR and UAE differed in their association with central arterial stiffness. Whereas both a lower eGFR and greater albuminuria were associated with a decrease in peripheral arterial stiffness, only greater albuminuria was associated with a lower CFTT (Figure 1). As stated in the foregoing, in individuals with mild to moderate renal insufficiency, conflicting results exist regarding the relation of eGFR with carotid-femoral PWV (32–34). In agreement with our results, in patients with type 2 diabetes (48) and in hypertensive patients (49), microalbuminuria has been associated with a greater carotid-femoral PWV. Again, one of the links between UAE and central arterial stiffness could be endothelial dysfunction and low-grade inflammation (50). However, also after adjustment for BA endothelial flow-mediated dilation, the associations between UAE and PWV remained largely unchanged. It is not clear why this relation is not seen between eGFR and central arterial stiffness.

Figure 1.
Figure 1.

Means of distensibility coefficient of carotid artery (103/kPa; A) and carotid-femoral transit time (ms; B) according to estimated GFR (eGFR; in tertiles) and urinary albumin creatinine ratio (UACR; in quartiles). *P < 0.05 for trend.

The potential clinical impact of our findings can be appreciated from the following comparisons. The aortic PWV is an independent predictor of cardiovascular morbidity and mortality, and all-cause mortality (27). The change in CFTT (%), an approximation of the PWV, per quartile of UACR was approximately 3%, which was associated with an increase of CVD risk of 18% in the Rotterdam Study (51) and an increase of all-cause mortality risk of 3% (52). Although only aortic and carotid stiffness have shown to be of predictive value for CVD in CKD populations (27), data on FA stiffness are also of potential clinical importance. At least in patients with type 2 diabetes, FA stiffness is a predictor of peripheral vascular disease (53,54). To the best of our knowledge, no data exist on the relation between FA stiffness and peripheral vascular disease in patients with CKD.

This study had several limitations. First, the study population was relatively old. This might have caused underestimation of the relation between eGFR or UAE and arterial stiffness. A “healthy survivor effect” may also have weakened the associations of eGFR or UAE with IMT. Second, our data were cross-sectional and do not provide insight into the mechanisms that are responsible for the observed associations. Third, we studied a white population, and it remains to be established whether the results can be generalized to other ethnicities.

Conclusion

In this population-based study, we showed that stages 2 to 3 CKD was associated with peripheral but not central arterial stiffness. We also showed that UAE, even below levels that conventionally are considered to define microalbuminuria, was associated with greater CCA stiffness and a decrease in CFTT. This finding questions the current arbitrary cutoff point for microalbuminuria. Furthermore, our findings suggest that in patients with CKD, both GFR and albuminuria should be interpreted as independent risk factors for CVD.

Our data underscore the importance of adequate treatment of patients with mild renal impairment with or without albuminuria. At present, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may have the best data on preventing a decline in renal function (55) and diminishing albuminuria (56). Most recently, in a hypertensive population, the combination of a calcium antagonist and an angiotensin-converting enzyme inhibitor resulted in a greater lowering of central aortic pressure and a better cardiovascular outcome compared with a strategy that consisted of a β blocker plus a diuretic (57). Most important, however, is a greater awareness of the importance of mild renal impairment and albuminuria for cardiovascular risk.

Disclosures

None.

Footnotes

  • Published online ahead of print. Publication date available at www.jasn.org.

References

  1. ↵
    K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 39 : S1 –S266, 2002
    OpenUrlCrossRefPubMed
  2. ↵
    Foley RN, Parfrey PS, Sarnak MJ: Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 9[Suppl] : S16 –S23, 1998
    OpenUrlCrossRefPubMed
  3. ↵
    Henry RM, Kostense PJ, Bos G, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD: Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study. Kidney Int 62 : 1402 –1407, 2002
    OpenUrlCrossRefPubMed
  4. ↵
    De Leeuw PW, Thijs L, Birkenhager WH, Voyaki SM, Efstratopoulos AD, Fagard RH, Leonetti G, Nachev C, Petrie JC, Rodicio JL, Rosenfeld JJ, Sarti C, Staessen JA: Prognostic significance of renal function in elderly patients with isolated systolic hypertension: Results from the Syst-Eur trial. J Am Soc Nephrol 13 : 2213 –2222, 2002
    OpenUrlAbstract/FREE Full Text
  5. ↵
    Stehouwer CD, Nauta JJ, Zeldenrust GC, Hackeng WH, Donker AJ, den Ottolander GJ: Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus. Lancet 340 : 319 –323, 1992
    OpenUrlCrossRefPubMed
  6. Hillege HL, Fidler V, Diercks GF, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, Gans RO, Janssen WM, Grobbee DE, de Jong PE: Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation 106 : 1777 –1782, 2002
    OpenUrlAbstract/FREE Full Text
  7. ↵
    Arnlov J, Evans JC, Meigs JB, Wang TJ, Fox CS, Levy D, Benjamin EJ, D’Agostino RB, Vasan RS: Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: The Framingham Heart Study. Circulation 112 : 969 –975, 2005
    OpenUrlAbstract/FREE Full Text
  8. ↵
    London GM: Alterations of arterial function in end-stage renal disease. Nephron 84 : 111 –118, 2000
    OpenUrlCrossRefPubMed
  9. Guerin AP, London GM, Marchais SJ, Metivier F: Arterial stiffening and vascular calcifications in end-stage renal disease. Nephrol Dial Transplant 15 : 1014 –1021, 2000
    OpenUrlCrossRefPubMed
  10. ↵
    Safar ME, London GM, Plante GE: Arterial stiffness and kidney function. Hypertension 43 : 163 –168, 2004
    OpenUrlAbstract/FREE Full Text
  11. ↵
    Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM: Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 103 : 987 –992, 2001
    OpenUrlAbstract/FREE Full Text
  12. ↵
    Blacher J, Safar ME, Guerin AP, Pannier B, Marchais SJ, London GM: Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int 63 : 1852 –1860, 2003
    OpenUrlCrossRefPubMed
  13. ↵
    Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D: A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130 : 461 –470, 1999
    OpenUrlCrossRefPubMed
  14. ↵
    Mooy JM, Grootenhuis PA, de Vries H, Valkenburg HA, Bouter LM, Kostense PJ, Heine RJ: Prevalence and determinants of glucose intolerance in a Dutch Caucasian population. The Hoorn Study. Diabetes Care 18 : 1270 –1273, 1995
    OpenUrlAbstract/FREE Full Text
  15. ↵
    Spijkerman AM, Adriaanse MC, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ: Diabetic patients detected by population-based stepwise screening already have a diabetic cardiovascular risk profile. Diabetes Care 25 : 1784 –1789, 2002
    OpenUrlAbstract/FREE Full Text
  16. ↵
    Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15 : 539 –553, 1998
    OpenUrlCrossRefPubMed
  17. ↵
    Henry RM, Kostense PJ, Spijkerman AM, Dekker JM, Nijpels G, Heine RJ, Kamp O, Westerhof N, Bouter LM, Stehouwer CD: Arterial stiffness increases with deteriorating glucose tolerance status: The Hoorn Study. Circulation 107 : 2089 –2095, 2003
    OpenUrlAbstract/FREE Full Text
  18. ↵
    Kelly R, Fitchett D: Noninvasive determination of aortic input impedance and external left ventricular power output: A validation and repeatability study of a new technique. J Am Coll Cardiol 20 : 952 –963, 1992
    OpenUrlCrossRefPubMed
  19. ↵
    Van Bortel LM, Balkestein EJ, van der Heijden-Spek JJ, Vanmolkot FH, Staessen JA, Kragten JA, Vredeveld JW, Safar ME, Struijker Boudier HA, Hoeks AP: Non-invasive assessment of local arterial pulse pressure: Comparison of applanation tonometry and echo-tracking. J Hypertens 19 : 1037 –1044, 2001
    OpenUrlCrossRefPubMed
  20. ↵
    O’Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plante GE: Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 15 : 426 –444, 2002
    OpenUrlCrossRefPubMed
  21. ↵
    Schram MT, Henry RM, van Dijk RA, Kostense PJ, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Westerhof N, Stehouwer CD: Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: The Hoorn Study. Hypertension 43 : 176 –181, 2004
    OpenUrlAbstract/FREE Full Text
  22. ↵
    Nichols WW, O’Rourke MF: Properties of the arterial wall. In: McDonald’s Blood Flow in Arteries, 4th Ed., London, Arnold, 1998 , pp 54 –72
  23. ↵
    van Dijk RA, van Ittersum FJ, Westerhof N, van Dongen EM, Kamp O, Stehouwer CD: Determinants of brachial artery mean 24 h pulse pressure in individuals with type II diabetes mellitus and untreated mild hypertension. Clin Sci (Lond) 102 : 177 –186, 2002
    OpenUrlPubMed
  24. ↵
    Davies JI, Struthers AD: Pulse wave analysis and pulse wave velocity: A critical review of their strengths and weaknesses. J Hypertens 21 : 463 –472, 2003
    OpenUrlCrossRefPubMed
  25. ↵
    Pannier BM, Avolio AP, Hoeks A, Mancia G, Takazawa K: Methods and devices for measuring arterial compliance in humans. Am J Hypertens 15 : 743 –753, 2002
    OpenUrlCrossRefPubMed
  26. ↵
    Chemla D, Hebert JL, Coirault C, Zamani K, Suard I, Colin P, Lecarpentier Y: Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans. Am J Physiol 274 : H500 –H505, 1998
    OpenUrlPubMed
  27. ↵
    Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H: Expert consensus document on arterial stiffness: Methodological issues and clinical applications. Eur Heart J 27 : 2588 –2605, 2006
    OpenUrlCrossRefPubMed
  28. ↵
    De Angelis L, Millasseau SC, Smith A, Viberti G, Jones RH, Ritter JM, Chowienczyk PJ: Sex differences in age-related stiffening of the aorta in subjects with type 2 diabetes. Hypertension 44 : 67 –71, 2004
    OpenUrlAbstract/FREE Full Text
  29. ↵
    Stam F, van Guldener C, Becker A, Dekker JM, Heine RJ, Bouter LM, Stehouwer CD: Endothelial dysfunction contributes to renal function-associated cardiovascular mortality in a population with mild renal insufficiency: The Hoorn study. J Am Soc Nephrol 17 : 537 –545, 2006
    OpenUrlAbstract/FREE Full Text
  30. ↵
    Amabile N, Guerin AP, Leroyer A, Mallat Z, Nguyen C, Boddaert J, London GM, Tedgui A, Boulanger CM: Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. J Am Soc Nephrol 16 : 3381 –3388, 2005
    OpenUrlAbstract/FREE Full Text
  31. ↵
    Konings CJ, Dammers R, Rensma PL, Kooman JP, Hoeks AP, Kornet L, Gladziwa U, van der Sande FM, Leunissen KM: Arterial wall properties in patients with renal failure. Am J Kidney Dis 39 : 1206 –1212, 2002
    OpenUrlCrossRefPubMed
  32. ↵
    Mourad JJ, Pannier B, Blacher J, Rudnichi A, Benetos A, London GM, Safar ME: Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension. Kidney Int 59 : 1834 –1841, 2001
    OpenUrlCrossRefPubMed
  33. ↵
    Wang MC, Tsai WC, Chen JY, Huang JJ: Stepwise increase in arterial stiffness corresponding with the stages of chronic kidney disease. Am J Kidney Dis 45 : 494 –501, 2005
    OpenUrlCrossRefPubMed
  34. ↵
    Briet M, Bozec E, Laurent S, Fassot C, London GM, Jacquot C, Froissart M, Houillier P, Boutouyrie P: Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int 69 : 350 –357, 2006
    OpenUrlCrossRefPubMed
  35. ↵
    van Dijk RA, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD: Brachial artery pulse pressure and common carotid artery diameter: Mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance. Eur J Clin Invest 31 : 756 –763, 2001
    OpenUrlCrossRefPubMed
  36. ↵
    Ward MR, Pasterkamp G, Yeung AC, Borst C: Arterial remodeling. Mechanisms and clinical implications. Circulation 102 : 1186 –1191, 2000
    OpenUrlFREE Full Text
  37. ↵
    Amann K, Neususs R, Ritz E, Irzyniec T, Wiest G, Mall G: Changes of vascular architecture independent of blood pressure in experimental uremia. Am J Hypertens 8 : 409 –417, 1995
    OpenUrlCrossRefPubMed
  38. ↵
    Safar ME, Thuilliez C, Richard V, Benetos A: Pressure-independent contribution of sodium to large artery structure and function in hypertension. Cardiovasc Res 46 : 269 –276, 2000
    OpenUrlCrossRefPubMed
  39. ↵
    Blacher J, Amah G, Girerd X, Kheder A, Ben Mais H, London GM, Safar ME: Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension. Am J Hypertens 10 : 1326 –1334, 1997
    OpenUrlPubMed
  40. ↵
    London GM, Guerin AP, Pannier B, Marchais SJ, Safar ME: Large artery structure and function in hypertension and end-stage renal disease. J Hypertens 16 : 1931 –1938, 1998
    OpenUrlCrossRefPubMed
  41. ↵
    London GM, Guerin AP, Marchais SJ, Pannier B, Safar ME, Day M, Metivier F: Cardiac and arterial interactions in end-stage renal disease. Kidney Int 50 : 600 –608, 1996
    OpenUrlCrossRefPubMed
  42. ↵
    Lambert J, Smulders RA, Aarsen M, Donker AJ, Stehouwer CD: Carotid artery stiffness is increased in microalbuminuric IDDM patients. Diabetes Care 21 : 99 –103, 1998
    OpenUrlAbstract/FREE Full Text
  43. ↵
    Giannattasio C, Failla M, Piperno A, Grappiolo A, Gamba P, Paleari F, Mancia G: Early impairment of large artery structure and function in type I diabetes mellitus. Diabetologia 42 : 987 –994, 1999
    OpenUrlCrossRefPubMed
  44. ↵
    Yokoyama H, Aoki T, Imahori M, Kuramitsu M: Subclinical atherosclerosis is increased in type 2 diabetic patients with microalbuminuria evaluated by intima-media thickness and pulse wave velocity. Kidney Int 66 : 448 –454, 2004
    OpenUrlCrossRefPubMed
  45. ↵
    Keech AC, Grieve SM, Patel A, Griffiths K, Skilton M, Watts GF, Marwick TH, Groshens M, Celermajer DS: Urinary albumin levels in the normal range determine arterial wall thickness in adults with type 2 diabetes: A FIELD substudy. Diabet Med 22 : 1558 –1565, 2005
    OpenUrlCrossRefPubMed
  46. ↵
    Kramer H, Jacobs DR Jr, Bild D, Post W, Saad MF, Detrano R, Tracy R, Cooper R, Liu K: Urine albumin excretion and subclinical cardiovascular disease. The Multi-Ethnic Study of Atherosclerosis. Hypertension 46 : 38 –43, 2005
    OpenUrlAbstract/FREE Full Text
  47. ↵
    Gerstein HC, Mann JF, Yi Q, Zinman B, Dinneen SF, Hoogwerf B, Halle JP, Young J, Rashkow A, Joyce C, Nawaz S, Yusuf S: Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 286 : 421 –426, 2001
    OpenUrlCrossRefPubMed
  48. ↵
    Smith A, Karalliedde J, De Angelis L, Goldsmith D, Viberti G: Aortic pulse wave velocity and albuminuria in patients with type 2 diabetes. J Am Soc Nephrol 16 : 1069 –1075, 2005
    OpenUrlAbstract/FREE Full Text
  49. ↵
    Mule G, Cottone S, Vadala A, Volpe V, Mezzatesta G, Mongiovi R, Piazza G, Nardi E, Andronico G, Cerasola G: Relationship between albumin excretion rate and aortic stiffness in untreated essential hypertensive patients. J Intern Med 256 : 22 –29, 2004
    OpenUrlCrossRefPubMed
  50. ↵
    Kinlay S, Creager MA, Fukumoto M, Hikita H, Fang JC, Selwyn AP, Ganz P: Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo. Hypertension 38 : 1049 –1053, 2001
    OpenUrlAbstract/FREE Full Text
  51. ↵
    Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC: Arterial stiffness and risk of coronary heart disease and stroke: The Rotterdam Study. Circulation 113 : 657 –663, 2006
    OpenUrlAbstract/FREE Full Text
  52. ↵
    Willum-Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, Jeppesen J: Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 113 : 664 –670, 2006
    OpenUrlAbstract/FREE Full Text
  53. ↵
    Kizu A, Koyama H, Tanaka S, Maeno T, Komatsu M, Fukumoto S, Emoto M, Shoji T, Inaba M, Shioi A, Miki T, Nishizawa Y: Arterial wall stiffness is associated with peripheral circulation in patients with type 2 diabetes. Atherosclerosis 170 : 87 –91, 2003
    OpenUrlCrossRefPubMed
  54. ↵
    Taniwaki H, Shoji T, Emoto M, Kawagishi T, Ishimura E, Inaba M, Okuno Y, Nishizawa Y: Femoral artery wall thickness and stiffness in evaluation of peripheral vascular disease in type 2 diabetes mellitus. Atherosclerosis 158 : 207 –214, 2001
    OpenUrlCrossRefPubMed
  55. ↵
    Ruggenenti P: Angiotensin-converting enzyme inhibition and angiotensin II antagonism in nondiabetic chronic nephropathies. Semin Nephrol 24 : 158 –167, 2004
    OpenUrlCrossRefPubMed
  56. ↵
    Parving HH, Andersen S, Jacobsen P, Christensen PK, Rossing K, Hovind P, Rossing P, Tarnow L: Angiotensin receptor blockers in diabetic nephropathy: Renal and cardiovascular end points. Semin Nephrol 24 : 147 –157, 2004
    OpenUrlCrossRefPubMed
  57. ↵
    Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, Hughes AD, Thurston H, O’Rourke M: Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: Principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 113 : 1213 –1225, 2006
    OpenUrlAbstract/FREE Full Text
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Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness: The Hoorn Study
Marc M.H. Hermans, Ronald Henry, Jacqueline M. Dekker, Jeroen P. Kooman, Piet J. Kostense, Giel Nijpels, Robert J. Heine, Coen D.A. Stehouwer
JASN Jun 2007, 18 (6) 1942-1952; DOI: 10.1681/ASN.2006111217
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