Article Figures & Data
Figures
- Figure 1.
Fasting and postprandial measurements of serum phosphorus (A), fractional excretion of phosphorus (B), FGF-23 (C), serum calcium (D), fractional excretion of calcium (E), and PTH (F) after meal 1 in healthy volunteers (○) and patients with CKD (▪). Time 0 represents the fasting measurements. Results are reported as means ± SE. *Significant (P < 0.05) differences at individual time points compared with the within-group's fasting level based on repeated measures linear regression models.
- Figure 2.
Fasting and postprandial measurements of serum phosphorus (A), fractional excretion of phosphorus (B), FGF-23 (C), serum calcium (D), fractional excretion of calcium (E), and PTH (F) after meal 2 in healthy volunteers (○) and patients with CKD (▪). Time 0 represents the fasting measurements. Results are reported as means ± SE. *Significant (P < 0.05) differences at individual time points compared with the within-group's fasting level based on repeated measures linear regression models.
- Figure 3.
Pooled results from meal 1 and meal 2 for healthy volunteers (A) and patients with CKD (B) to compare the temporal relationships between changes in serum calcium, fractional excretion of calcium, and PTH. Time 0 represents the fasting measurements. Results are reported as means ± SE. *Significant (P < 0.05) differences at individual time points compared with the within-group's fasting level based on repeated measures linear regression models.
Tables
Parameter Meal 1 Meal 2 Healthy (n = 21) CKD (n = 13) P Healthy (n = 11) CKD (n = 10) P Serum creatinine (mg/dl) 0.9 ± 0.1 1.8 ± 0.3 <0.01 0.9 ± 0.1 1.8 ± 0.3 <0.01 Serum phosphorus (mg/dl) 3.1 ± 0.5 3.1 ± 0.6 NS 3.2 ± 0.6 3.0 ± 0.6 NS Serum calcium (mg/dl) 9.2 ± 0.3 9.3 ± 0.3 NS 9.2 ± 0.4 9.2 ± 0.3 NS Fractional excretion phosphorus (%) 16 ± 7 30 ± 9 <0.01 16 ± 8 29 ± 10 <0.01 Fractional excretion calcium (%) 0.9 (0.7 to 1.3) 0.5 (0.2 to 0.7) <0.01 0.9 (0.8 to 1.8) 0.5 (0.2 to 0.8) 0.02 PTH (pg/ml) 30 ± 14 38 ± 19 NS 25 ± 6 29 ± 17 NS FGF-23 (pg/ml) 52 ± 24 84 ± 24 <0.01 50 ± 21 78 ± 20 <0.01 25D (ng/ml) 39 ± 9 35 ± 8 NS – – – 1,25D (pg/ml) 41 ± 11 24 ± 10 <0.01 – – – ↵a Data are means ± SD for normally distributed variables and median (interquartile range) for variables with skewed distributions.
Parameter Meal 1 Meal 2 Items 1 slice whole-wheat toast 1 English muffin 25 g wheat bran cereal 25 g Rice Krispies cereal 0.5 cup applesauce 0.5 cup applesauce 4 oz 1% milk 4 oz 1% milk 4 oz orange juice 4 oz orange juice 8 oz coffee 8 oz coffee 2 pats butter 3 pats butter 4 oz yogurt Phosphorus (mg) 500 250 Calcium (mg) 389 272 Sodium (mEq) 23 30 Carbohydrate (%) 65 62 Fat (%) 23 29 Protein (%) 12 9 Calories (kcal) 503 502
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- Daily Variability in Mineral Metabolites in CKD and Effects of Dietary Calcium and Calcitriol
- Fibroblast Growth Factor 23 in Patients Undergoing Peritoneal Dialysis
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- Association of Serum Phosphate Levels With Aortic Valve Sclerosis and Annular Calcification: The Cardiovascular Health Study
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- Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney Disease
- Fibroblast Growth Factor 23 and Disordered Vitamin D Metabolism in Chronic Kidney Disease: Updating the "Trade-off" Hypothesis
- Forging Forward with 10 Burning Questions on FGF23 in Kidney Disease
- Fibroblast Growth Factor-23 in Early Chronic Kidney Disease: Additional Support in Favor of a Phosphate-Centric Paradigm for the Pathogenesis of Secondary Hyperparathyroidism
- Common Genetic Variants Associate with Serum Phosphorus Concentration
- Understanding Sources of Dietary Phosphorus in the Treatment of Patients with Chronic Kidney Disease
- The Journey From Vitamin D-Resistant Rickets to the Regulation of Renal Phosphate Transport