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BASIC RESEARCH
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Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells

Olena Glushakova, Tomoki Kosugi, Carlos Roncal, Wei Mu, Marcelo Heinig, Pietro Cirillo, Laura G. Sánchez-Lozada, Richard J. Johnson and Takahiko Nakagawa
JASN September 2008, 19 (9) 1712-1720; DOI: https://doi.org/10.1681/ASN.2007121304
Olena Glushakova
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Tomoki Kosugi
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Carlos Roncal
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Wei Mu
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Marcelo Heinig
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Pietro Cirillo
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Laura G. Sánchez-Lozada
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Richard J. Johnson
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Takahiko Nakagawa
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Abstract

Epidemiologic studies have linked fructose intake with the metabolic syndrome, and it was recently reported that fructose induces an inflammatory response in the rat kidney. Here, we examined whether fructose directly stimulates endothelial inflammatory processes by upregulating the inflammatory molecule intercellular adhesion molecule-1 (ICAM-1). When human aortic endothelial cells were stimulated with physiologic concentrations of fructose, ICAM-1 mRNA and protein expression increased in a time- and dosage-dependent manner, which was independent of NF-κB activation. Fructose reduced endothelial nitric oxide (NO) levels and caused a transient reduction in endothelial NO synthase expression. The administration of an NO donor inhibited fructose-induced ICAM-1 expression, whereas blocking NO synthase enhanced it, suggesting that NO inhibits endothelial ICAM-1 expression. Furthermore, fructose resulted in decreased intracellular ATP; administration of exogenous ATP blocked fructose-induced ICAM-1 expression and increased NO levels. Consistent with the in vitro studies, dietary intake of fructose at physiologic dosages increased both serum ICAM-1 concentration and endothelial ICAM-1 expression in the rat kidney. These data suggest that fructose induces inflammatory changes in vascular cells at physiologic concentrations.

  • © 2008 American Society of Nephrology
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Journal of the American Society of Nephrology: 19 (9)
Journal of the American Society of Nephrology
Vol. 19, Issue 9
September 2008
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Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells
Olena Glushakova, Tomoki Kosugi, Carlos Roncal, Wei Mu, Marcelo Heinig, Pietro Cirillo, Laura G. Sánchez-Lozada, Richard J. Johnson, Takahiko Nakagawa
JASN Sep 2008, 19 (9) 1712-1720; DOI: 10.1681/ASN.2007121304

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Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells
Olena Glushakova, Tomoki Kosugi, Carlos Roncal, Wei Mu, Marcelo Heinig, Pietro Cirillo, Laura G. Sánchez-Lozada, Richard J. Johnson, Takahiko Nakagawa
JASN Sep 2008, 19 (9) 1712-1720; DOI: 10.1681/ASN.2007121304
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