Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Subject Collections
    • JASN Podcasts
    • Archives
    • Saved Searches
    • ASN Meeting Abstracts
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Subscriptions
  • More
    • About JASN
    • Alerts
    • Advertising
    • Editorial Fellowship Program
    • Feedback
    • Reprints
    • Impact Factor
  • ASN Kidney News
  • Other
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Subject Collections
    • JASN Podcasts
    • Archives
    • Saved Searches
    • ASN Meeting Abstracts
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Subscriptions
  • More
    • About JASN
    • Alerts
    • Advertising
    • Editorial Fellowship Program
    • Feedback
    • Reprints
    • Impact Factor
  • ASN Kidney News
  • Follow JASN on Twitter
  • Visit ASN on Facebook
  • Follow JASN on RSS
  • Community Forum
CLINICAL EPIDEMIOLOGY
You have accessRestricted Access

Change in Estimated GFR Associates with Coronary Heart Disease and Mortality

Kunihiro Matsushita, Elizabeth Selvin, Lori D. Bash, Nora Franceschini, Brad C. Astor and Josef Coresh
JASN December 2009, 20 (12) 2617-2624; DOI: https://doi.org/10.1681/ASN.2009010025
Kunihiro Matsushita
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth Selvin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lori D. Bash
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nora Franceschini
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brad C. Astor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josef Coresh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

Abstract

Kidney function predicts cardiovascular and all-cause mortality, but little is known about the association of changes in estimated GFR (eGFR) with clinical outcomes. We investigated whether 3- and 9-yr changes in eGFR associated with risk for coronary heart disease (CHD) and all-cause mortality among 13,029 participants of the Atherosclerosis Risk in Communities (ARIC) Study. After adjustment for baseline covariates including eGFR in Cox proportional hazards models, the quartile of participants with the greatest annual decline (annual decline ≥5.65%) in eGFR were at significantly greater risk for CHD and all-cause mortality (hazard ratio 1.30 [95% confidence interval 1.11 to 1.52] and 1.22 [95% confidence interval 1.06 to 1.41], respectively) compared with the third quartile (annual decline between 0.33 and 0.47%). We observed similar results when we analyzed 9-yr changes in eGFR. Adjustment for covariates at the second eGFR used to estimate change reduced the association with CHD but not with mortality. Among participants with stage 3 chronic kidney disease, an increase in eGFR during the first 3 yr also associated with a higher risk for mortality, perhaps as a result of clinical instability. In conclusion, a steeper than average decline in eGFR associates with a higher risk for CHD and all-cause mortality. Increases in eGFR among participants with chronic kidney disease associate with similar increased risks.

Footnotes

    • Copyright © 2009 by the American Society of Nephrology
    View Full Text
    PreviousNext
    Back to top

    In this issue

    Journal of the American Society of Nephrology: 20 (12)
    Journal of the American Society of Nephrology
    Vol. 20, Issue 12
    1 Dec 2009
    • Table of Contents
    • Table of Contents (PDF)
    • Index by author
    View Selected Citations (0)
    Print
    Download PDF
    Sign up for Alerts
    Email Article
    Thank you for your help in sharing the high-quality science in JASN.
    Enter multiple addresses on separate lines or separate them with commas.
    Change in Estimated GFR Associates with Coronary Heart Disease and Mortality
    (Your Name) has sent you a message from American Society of Nephrology
    (Your Name) thought you would like to see the American Society of Nephrology web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    Change in Estimated GFR Associates with Coronary Heart Disease and Mortality
    Kunihiro Matsushita, Elizabeth Selvin, Lori D. Bash, Nora Franceschini, Brad C. Astor, Josef Coresh
    JASN Dec 2009, 20 (12) 2617-2624; DOI: 10.1681/ASN.2009010025

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Request Permissions
    Share
    Change in Estimated GFR Associates with Coronary Heart Disease and Mortality
    Kunihiro Matsushita, Elizabeth Selvin, Lori D. Bash, Nora Franceschini, Brad C. Astor, Josef Coresh
    JASN Dec 2009, 20 (12) 2617-2624; DOI: 10.1681/ASN.2009010025
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like

    Jump to section

    • Article
      • Abstract
      • Results
      • Discussion
      • Concise Methods
      • Disclosures
      • Acknowledgments
      • Footnotes
      • References
    • Figures & Data Supps
    • Info & Metrics
    • View PDF

    More in this TOC Section

    • Subtyping CKD Patients by Consensus Clustering: The Chronic Renal Insufficiency Cohort (CRIC) Study
    • Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China
    • Association of Multiple Plasma Biomarker Concentrations with Progression of Prevalent Diabetic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study
    Show more Clinical Epidemiology

    Cited By...

    • Slope of Kidney Function and Its Association with Longitudinal Mortality and Cardiovascular Disease among Individuals with CKD
    • Is there a correlation between an eGFR slope measured over a 5-year period and incident cardiovascular events in the following 5 years among a Flemish general practice population: a retrospective cohort study
    • Kidney Function Decline in Patients with CKD and Untreated Hepatitis C Infection
    • APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults
    • Time-Centered Approach to Understanding Risk Factors for the Progression of CKD
    • Kidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study
    • Sleep and CKD in Chinese Adults: A Cross-Sectional Study
    • Past Decline Versus Current eGFR and Subsequent Mortality Risk
    • Past Decline Versus Current eGFR and Subsequent ESRD Risk
    • Change in Measured GFR Versus eGFR and CKD Outcomes
    • Dynamic Changes in Renal Function Are Associated With Major Cardiovascular Events in Patients With Type 2 Diabetes
    • Health Education and General Practitioner Training in Hypertension Management: Long-Term Effects on Kidney Function
    • Structural Predictors of Renal Function Decline
    • Rate of Kidney Function Decline and Risk of Hospitalizations in Stage 3A CKD
    • Rate of Change in Renal Function and Mortality in Elderly Treated Hypertensive Patients
    • Change in Multiple Filtration Markers and Subsequent Risk of Cardiovascular Disease and Mortality
    • Short-Term Change in eGFR and Risk of Cardiovascular Events
    • APOL1 Variants Associate with Increased Risk of CKD among African Americans
    • More Evidence on an Abominable Pairing: Atrial Fibrillation and Kidney Disease
    • Web Surveillance for CKD
    • Vascular Disease, ESRD, and Death: Interpreting Competing Risk Analyses
    • Improvement in Kidney Function: A Real Occurrence
    • Urine Volume and Change in Estimated GFR in a Community-Based Cohort Study
    • Screening for Proteinuria: A Tool for Predicting Rapid Declines in Kidney Function?
    • Dipstick Proteinuria as a Screening Strategy to Identify Rapid Renal Decline
    • Change in Kidney Function over Time and Risk for Adverse Outcomes: Is an Increasing Estimated GFR Harmful?
    • GFR Decline and Mortality Risk among Patients with Chronic Kidney Disease
    • World Kidney Day 2011: Protect Your Kidneys, Save Your Heart
    • Prediction Modeling to Assess the Prognostic Significance of a Biomarker Panel
    • Rate of Kidney Function Decline Associates with Increased Risk of Death
    • Rate of Kidney Function Decline Associates with Mortality
    • Mechanisms of Tubulointerstitial Fibrosis
    • Prediabetes, Prehypertension ... Is It Time for Pre-CKD?
    • Google Scholar

    Similar Articles

    Related Articles

    • PubMed
    • Google Scholar

    Articles

    • Current Issue
    • Early Access
    • Subject Collections
    • Article Archive
    • ASN Annual Meeting Abstracts

    Information for Authors

    • Submit a Manuscript
    • Author Resources
    • Editorial Fellowship Program
    • ASN Journal Policies
    • Reuse/Reprint Policy

    About

    • JASN
    • ASN
    • ASN Journals
    • ASN Kidney News

    Journal Information

    • About JASN
    • JASN Email Alerts
    • JASN Key Impact Information
    • JASN Podcasts
    • JASN RSS Feeds
    • Editorial Board

    More Information

    • Advertise
    • ASN Podcasts
    • ASN Publications
    • Become an ASN Member
    • Feedback
    • Follow on Twitter
    • Password/Email Address Changes
    • Subscribe

    © 2021 American Society of Nephrology

    Print ISSN - 1046-6673 Online ISSN - 1533-3450

    Powered by HighWire