Article Figures & Data
Figures
- Figure 1.
Participant enrollment and randomization to the study. Arm A (left column) allocated to oral bicarbonate and arm B (right colum) allocated to standard therapy.
- Figure 2.
(A) Plasma HCO3− levels during the study period. Squares and bars denote means and SD. (B) Urinary sodium (Na) excretion per day. Squares and bars denote means and SD. (C) BP control during the study period. Squares and bars denote means and SD. (D) Urinary total protein excretion per day during the study period. Squares and bars denote means and SD. (E) Rate of decline of CrCl. Squares and bars denote means and SD.
- Figure 3.
Kaplan-Meier analysis to assess the probability of reaching ESRD for the two groups.
- Figure 4.
(A) Dietary protein intake on 4-d patient dietary records. Data are means and SD. (B) nPNA during the study period. Data are means and SD. (C) MAMC measurements during the study period. Data are means and SD. (D) Plasma albumin levels in the control and bicarbonate groups during the study period. Data are means and SD. (E) Serum potassium levels in the control and bicarbonate groups during the study period. Data are means and SD.
Tables
Variable Control Bicarbonate Demographic age (yr; mean ± SE) 54.77 ± 2.34 54.78 ± 2.56 male (%) 51 52 white (%) 52 52 black/Asian (%) 48 48 Diagnosis (%) diabetes 36 37 hypertension 26 29 CRF unknown 14 10 glomerulonephritis 13 10 obstructive uropathy 4 1 other 7 12 Medications (%) loop diuretics 67 70 moxonodine 15 17 α blockers 57 59 β blockers 17 19 calcium channel blockers 48 50 ACEIs/ARBs 48 50 allopurinol 3 0 -
↵aCRF, chronic renal failure.
-
Variable Control Bicarbonate P Weight (kg) 74.9 ± 11.5 76.6 ± 21.1 0.84 Systolic BP (mmHg) 123.7 ± 1.2 124.0 ± 1.3 0.84 Diastolic BP (mmHg) 75.4 ± 1.9 76.1 ± 1.5 0.91 MAMC (cm) 24.8 ± 2.4 24.6 ± 2.9 0.81 Albumin (g/L) 35.1 ± 0.8 34.7 ± 0.5 0.76 Bicarbonate (mmol/L) 19.9 ± 1.5 19.8 ± 2.2 0.66 CrCl (ml/min per 1.73 m2) 20.70 ± 5.55 20.12 ± 6.47 0.60 Urinary Na (mmol/L) 140.1 ± 4.4 140.0 ± 7.9 0.96 Urinary protein (g/24 h) 1.8 ± 0.2 1.7 ± 0.8 0.84 -
↵aData are means ± SE.
-
Adverse Events Control (% of Patients) Bicarbonate (% of Patients) P Hospitalization for CHF 0 0 N/A Worsening hypertension requiring increase in therapy 48 61 0.17 Worsening edema requiring increase in loop diuretics 30 39 0.5 Bad taste requiring switch to powder form of sodium bicarbonate N/A 6.5 N/A -
↵aCHF, congestive heart failure.
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Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status
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Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status
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