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Up Front MattersBrief Reviews
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The Circadian Clock in the Kidney

Lisa R. Stow and Michelle L. Gumz
JASN April 2011, 22 (4) 598-604; DOI: https://doi.org/10.1681/ASN.2010080803
Lisa R. Stow
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Michelle L. Gumz
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Abstract

Circadian variations in renal function were first described in the 19th century, and GFR, renal blood flow, urine production, and electrolyte excretion exhibit daily oscillations. These clinical observations are well established, but the underlying mechanisms that govern circadian fluctuations in kidney are not fully understood. Here we provide a brief overview of the machinery governing the circadian clock and examine the clinical and molecular evidence supporting a critical role for circadian rhythm in the kidney. There is a connection between BP oscillation and renal disease that supports the use of chronotherapy in the treatment of hypertension or correction of nondipping BP. Such studies support a developing model of clock controlled sodium and water transport in renal epithelial cells. Recent advances in identifying novel clock-controlled genes using rodent and cellular models also shed light on the molecular mechanisms by which the circadian clock controls renal function; however, the field is new and much more work remains.

  • Copyright © 2011 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 22 (4)
Journal of the American Society of Nephrology
Vol. 22, Issue 4
1 Apr 2011
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The Circadian Clock in the Kidney
Lisa R. Stow, Michelle L. Gumz
JASN Apr 2011, 22 (4) 598-604; DOI: 10.1681/ASN.2010080803

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The Circadian Clock in the Kidney
Lisa R. Stow, Michelle L. Gumz
JASN Apr 2011, 22 (4) 598-604; DOI: 10.1681/ASN.2010080803
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  • Article
    • Abstract
    • ROLE OF THE CIRCADIAN CLOCK IN THE KIDNEY: CLINICAL EVIDENCE
    • MOLECULAR EVIDENCE FOR THE ROLE OF A CIRCADIAN CLOCK IN THE KIDNEY
    • THE FUTURE
    • CONCLUSIONS
    • DISCLOSURES
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  • Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism
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