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Brief Communication
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Temporal Changes in Incidence of Dialysis-Requiring AKI

Raymond K. Hsu, Charles E. McCulloch, R. Adams Dudley, Lowell J. Lo and Chi-yuan Hsu
JASN January 2013, 24 (1) 37-42; DOI: https://doi.org/10.1681/ASN.2012080800
Raymond K. Hsu
*Departments of Medicine and
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Charles E. McCulloch
†Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, California
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R. Adams Dudley
*Departments of Medicine and
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Lowell J. Lo
*Departments of Medicine and
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Chi-yuan Hsu
*Departments of Medicine and
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Abstract

The population epidemiology of AKI is not well described. Here, we analyzed data from the Nationwide Inpatient Sample, a nationally representative dataset, to identify cases of dialysis-requiring AKI using validated International Classification of Diseases, Ninth Revision (ICD-9) codes. From 2000 to 2009, the incidence of dialysis-requiring AKI increased from 222 to 533 cases per million person-years, averaging a 10% increase per year (incidence rate ratio=1.10, 95% CI=1.10–1.11 per year). Older age, male sex, and black race associated with higher incidence of dialysis-requiring AKI. The rapid increase in incidence was evident in all age, sex, and race subgroups examined. Temporal changes in the population distribution of age, race, and sex as well as trends of sepsis, acute heart failure, and receipt of cardiac catheterization and mechanical ventilation accounted for about one third of the observed increase in dialysis-requiring AKI among hospitalized patients. The total number of deaths associated with dialysis-requiring AKI rose from 18,000 in 2000 to nearly 39,000 in 2009. In conclusion, the incidence of dialysis-requiring AKI increased rapidly in all patient subgroups in the past decade in the United States, and the number of deaths associated with dialysis-requiring AKI more than doubled.

  • Copyright © 2013 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 24 (1)
Journal of the American Society of Nephrology
Vol. 24, Issue 1
January 2013
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Temporal Changes in Incidence of Dialysis-Requiring AKI
Raymond K. Hsu, Charles E. McCulloch, R. Adams Dudley, Lowell J. Lo, Chi-yuan Hsu
JASN Jan 2013, 24 (1) 37-42; DOI: 10.1681/ASN.2012080800

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Temporal Changes in Incidence of Dialysis-Requiring AKI
Raymond K. Hsu, Charles E. McCulloch, R. Adams Dudley, Lowell J. Lo, Chi-yuan Hsu
JASN Jan 2013, 24 (1) 37-42; DOI: 10.1681/ASN.2012080800
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