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Up Front MattersBrief Reviews
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Mechanistic Insights into Vascular Calcification in CKD

Rukshana Shroff, David A. Long and Catherine Shanahan
JASN February 2013, 24 (2) 179-189; DOI: https://doi.org/10.1681/ASN.2011121191
Rukshana Shroff
*Nephro-Urology Unit, Great Ormond Street Hospital for Children and University College London Institute of Child Health, London, United Kingdom; and
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David A. Long
*Nephro-Urology Unit, Great Ormond Street Hospital for Children and University College London Institute of Child Health, London, United Kingdom; and
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Catherine Shanahan
†BHF Centre, Division of Cardiovascular Medicine, Kings College London, London, United Kingdom
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    Figure 1.

    Mechanisms of calcification in VSMCs in culture and in intact vessel rings in predialysis and dialysis vessels. Superscript numbers indicate references to relevant articles.

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    Figure 2.

    In vivo changes in intact vessel rings from predialysis and dialysis vessels. Reprinted with permission from Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM: Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 118: 1748–1757.

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    Figure 3.

    Potential mechanisms of action of VDRAs on VSMCs.

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    Figure 4.

    Vascular growth factors and calcification. One of the earliest phases of CVD is disturbances in molecules that control blood vessel growth such as VEGF-A and Ang. These could modify vascular calcification either indirectly by altering endothelia biology and the expression of vascular tone mediators, which in turn affect the VSMC. Alternatively, VEGF and Ang may alter VSMCs biology directly because their receptors are also found on these cells.

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Journal of the American Society of Nephrology: 24 (2)
Journal of the American Society of Nephrology
Vol. 24, Issue 2
February 2013
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Mechanistic Insights into Vascular Calcification in CKD
Rukshana Shroff, David A. Long, Catherine Shanahan
JASN Feb 2013, 24 (2) 179-189; DOI: 10.1681/ASN.2011121191

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Mechanistic Insights into Vascular Calcification in CKD
Rukshana Shroff, David A. Long, Catherine Shanahan
JASN Feb 2013, 24 (2) 179-189; DOI: 10.1681/ASN.2011121191
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  • Article
    • Abstract
    • Sites of Calcification and Their Clinical Consequences
    • Model Systems to Study Vascular Calcification
    • Vascular Calcification Is Similar to Physiologic Bone Ossification
    • Cellular Mechanisms of Calcium- and Phosphate-Induced Calcification
    • Accelerated Calcification in Vessels from Children on Dialysis: Clinicopathological Correlations
    • Emerging Concepts in VSMC Calcification
    • Clinical Perspective
    • Future Directions
    • Disclosures
    • Acknowledgments
    • Footnotes
    • References
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Cited By...

  • Targeting Vascular Calcification in Chronic Kidney Disease
  • Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice
  • Microvasculopathy And Soft Tissue Calcification In Mice Are Governed by Fetuin-A, Pyrophosphate And Magnesium
  • Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study
  • Abdominal Aortic Calcifications Predict Survival in Peritoneal Dialysis Patients
  • Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-{kappa}B
  • Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein)
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  • Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products as a Possible Mechanism for Uremia-Related Atherosclerosis
  • Uremic Toxicity of Advanced Glycation End Products in CKD
  • NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency
  • Vascular Calcification in Predialysis CKD: Common and Deadly
  • Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System
  • HDL in Children with CKD Promotes Endothelial Dysfunction and an Abnormal Vascular Phenotype
  • Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats
  • Associations of FGF-23 and sKlotho with Cardiovascular Outcomes among Patients with CKD Stages 2-4
  • Coronary Artery Calcification: Pathogenesis and Prognostic Implications
  • Serum Calcification Propensity Predicts All-Cause Mortality in Predialysis CKD
  • Single FGF-23 Measurement and Time-Averaged Plasma Phosphate Levels in Hemodialysis Patients
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