Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Subject Collections
    • JASN Podcasts
    • Archives
    • Saved Searches
    • ASN Meeting Abstracts
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Subscriptions
  • More
    • About JASN
    • Alerts
    • Advertising
    • Editorial Fellowship Program
    • Feedback
    • Reprints
    • Impact Factor
  • ASN Kidney News
  • Other
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Subject Collections
    • JASN Podcasts
    • Archives
    • Saved Searches
    • ASN Meeting Abstracts
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Subscriptions
  • More
    • About JASN
    • Alerts
    • Advertising
    • Editorial Fellowship Program
    • Feedback
    • Reprints
    • Impact Factor
  • ASN Kidney News
  • Follow JASN on Twitter
  • Visit ASN on Facebook
  • Follow JASN on RSS
  • Community Forum
Up Front MattersBrief Reviews
You have accessRestricted Access

Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis

Jean-Marc Bugnicourt, Olivier Godefroy, Jean-Marc Chillon, Gabriel Choukroun and Ziad A. Massy
JASN March 2013, 24 (3) 353-363; DOI: https://doi.org/10.1681/ASN.2012050536
Jean-Marc Bugnicourt
*Service de Neurologie,
†Laboratoire de Neurosciences Fonctionnelles et Pathologies EA 4559, Amiens, France;
‡INSERM U1088, Amiens, France; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olivier Godefroy
*Service de Neurologie,
†Laboratoire de Neurosciences Fonctionnelles et Pathologies EA 4559, Amiens, France;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Marc Chillon
‡INSERM U1088, Amiens, France; and
§Université de Picardie Jules Verne, Amiens, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gabriel Choukroun
‡INSERM U1088, Amiens, France; and
‖Service de Néphrologie,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ziad A. Massy
‡INSERM U1088, Amiens, France; and
§Université de Picardie Jules Verne, Amiens, France
¶Services de Pharmacologie Clinique et Néphrologie, CHU Amiens, Amiens, France;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

Abstract

Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.

  • Copyright © 2013 by the American Society of Nephrology
View Full Text
PreviousNext
Back to top

In this issue

Journal of the American Society of Nephrology: 24 (3)
Journal of the American Society of Nephrology
Vol. 24, Issue 3
March 2013
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in JASN.
Enter multiple addresses on separate lines or separate them with commas.
Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
Jean-Marc Bugnicourt, Olivier Godefroy, Jean-Marc Chillon, Gabriel Choukroun, Ziad A. Massy
JASN Mar 2013, 24 (3) 353-363; DOI: 10.1681/ASN.2012050536

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
Jean-Marc Bugnicourt, Olivier Godefroy, Jean-Marc Chillon, Gabriel Choukroun, Ziad A. Massy
JASN Mar 2013, 24 (3) 353-363; DOI: 10.1681/ASN.2012050536
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Prevalence and Characteristics of Cognitive Impairment in CKD
    • Brain Imaging in CKD Patients
    • Potential Causes of Cognitive Impairment in Patients with CKD
    • Conclusion
    • Disclosures.
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

Up Front Matters

  • Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases
  • COVID-19–Associated Acute Kidney Injury: Learning from the First Wave
  • Will Targeting Interleukin-6 in the Anemia of CKD Change Our Treatment Paradigm?
Show more Up Front Matters

Brief Reviews

  • Targeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives
  • The UMOD Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease
  • Differentiating Primary, Genetic, and Secondary FSGS in Adults: A Clinicopathologic Approach
Show more Brief Reviews

Cited By...

  • Decline in kidney function over the course of adulthood and cognitive function in midlife
  • Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis
  • Measuring Patient Activation as Part of Kidney Disease Policy: Are We There Yet?
  • Uremic Toxic Blood-Brain Barrier Disruption Mediated by AhR Activation Leads to Cognitive Impairment during Experimental Renal Dysfunction
  • Association between chronic kidney disease and incident diagnosis of dementia in England: a cohort study in Clinical Practice Research Datalink
  • Walking while Talking in Older Adults with Chronic Kidney Disease
  • Association of 24-Hour Ambulatory Blood Pressure Patterns with Cognitive Function and Physical Functioning in CKD
  • Disentangling the multiple links between renal dysfunction and cerebrovascular disease
  • Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults
  • Intradialytic Cerebral Hypoperfusion as Mechanism for Cognitive Impairment in Patients on Hemodialysis
  • Acute Toxic Leukoencephalopathy: Etiologies, Imaging Findings, and Outcomes in 101 Patients
  • Neurological complications of renal dialysis and transplantation
  • Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation
  • Author response: Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies
  • Pulse-wave velocity is associated with cognitive impairment in haemodialysis patients
  • Kidney-brain axis inflammatory cross-talk: from bench to bedside
  • Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies
  • Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?
  • Kidney Function and Cerebral Blood Flow: The Rotterdam Study
  • Evaluation of Neurocognition in Youth with CKD Using a Novel Computerized Neurocognitive Battery
  • Kidney function and microstructural integrity of brain white matter
  • Cerebral Structural Changes in Diabetic Kidney Disease: African American-Diabetes Heart Study MIND
  • Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease
  • Vitamin D: An Intervention for Cognitive Impairment in Hemodialysis Patients That Could Make Sense
  • Google Scholar

Similar Articles

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Annual Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Author Resources
  • Editorial Fellowship Program
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • JASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About JASN
  • JASN Email Alerts
  • JASN Key Impact Information
  • JASN Podcasts
  • JASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe

© 2021 American Society of Nephrology

Print ISSN - 1046-6673 Online ISSN - 1533-3450

Powered by HighWire