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Clinical Research
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Central Body Fat Distribution Associates with Unfavorable Renal Hemodynamics Independent of Body Mass Index

Arjan J. Kwakernaak, Dorien M. Zelle, Stephan J.L. Bakker and Gerjan Navis
JASN June 2013, 24 (6) 987-994; DOI: https://doi.org/10.1681/ASN.2012050460
Arjan J. Kwakernaak
Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
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Dorien M. Zelle
Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
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Stephan J.L. Bakker
Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
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Gerjan Navis
Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
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Abstract

Central distribution of body fat is associated with a higher risk of renal disease, but whether it is the distribution pattern or the overall excess weight that underlies this association is not well understood. Here, we studied the association between waist-to-hip ratio (WHR), which reflects central adiposity, and renal hemodynamics in 315 healthy persons with a mean body mass index (BMI) of 24.9 kg/m2 and a mean 125I-iothalamate GFR of 109 ml/min per 1.73 m2. In multivariate analyses, WHR was associated with lower GFR, lower effective renal plasma flow, and higher filtration fraction, even after adjustment for sex, age, mean arterial pressure, and BMI. Multivariate models produced similar results regardless of whether the hemodynamic measures were indexed to body surface area. Thus, these results suggest that central body fat distribution, independent of BMI, is associated with an unfavorable pattern of renal hemodynamic measures that could underlie the increased renal risk reported in observational studies.

  • Copyright © 2013 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 24 (6)
Journal of the American Society of Nephrology
Vol. 24, Issue 6
June 2013
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Central Body Fat Distribution Associates with Unfavorable Renal Hemodynamics Independent of Body Mass Index
Arjan J. Kwakernaak, Dorien M. Zelle, Stephan J.L. Bakker, Gerjan Navis
JASN Jun 2013, 24 (6) 987-994; DOI: 10.1681/ASN.2012050460

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Central Body Fat Distribution Associates with Unfavorable Renal Hemodynamics Independent of Body Mass Index
Arjan J. Kwakernaak, Dorien M. Zelle, Stephan J.L. Bakker, Gerjan Navis
JASN Jun 2013, 24 (6) 987-994; DOI: 10.1681/ASN.2012050460
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