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Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers

Albert Q. Lam, Benjamin S. Freedman, Ryuji Morizane, Paul H. Lerou, M. Todd Valerius and Joseph V. Bonventre
JASN June 2014, 25 (6) 1211-1225; DOI: https://doi.org/10.1681/ASN.2013080831
Albert Q. Lam
*Renal Division, Department of Medicine, and
†Harvard Stem Cell Institute, Cambridge, Massachusetts; and
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Benjamin S. Freedman
*Renal Division, Department of Medicine, and
†Harvard Stem Cell Institute, Cambridge, Massachusetts; and
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Ryuji Morizane
*Renal Division, Department of Medicine, and
‡Internal Medicine, Keio University School of Medicine, Tokyo, Japan
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Paul H. Lerou
†Harvard Stem Cell Institute, Cambridge, Massachusetts; and
§Department of Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts;
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M. Todd Valerius
*Renal Division, Department of Medicine, and
†Harvard Stem Cell Institute, Cambridge, Massachusetts; and
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Joseph V. Bonventre
*Renal Division, Department of Medicine, and
†Harvard Stem Cell Institute, Cambridge, Massachusetts; and
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Article Information

vol. 25 no. 6 1211-1225
DOI 
https://doi.org/10.1681/ASN.2013080831
PubMed 
24357672

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication August 5, 2013
  • Accepted for publication November 9, 2013
  • Published online May 30, 2014.

Article Versions

  • Earlier version (December 19, 2013 - 07:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2014 by the American Society of Nephrology

Author Information

  1. Albert Q. Lam*†,
  2. Benjamin S. Freedman*†,
  3. Ryuji Morizane*‡,
  4. Paul H. Lerou†§,
  5. M. Todd Valerius*† and
  6. Joseph V. Bonventre*†
  1. *Renal Division, Department of Medicine, and
  2. §Department of Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts;
  3. †Harvard Stem Cell Institute, Cambridge, Massachusetts; and
  4. ‡Internal Medicine, Keio University School of Medicine, Tokyo, Japan
  1. Correspondence:
    Dr. Albert Q. Lam, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115. Email: aqlam{at}partners.org

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Journal of the American Society of Nephrology: 25 (6)
Journal of the American Society of Nephrology
Vol. 25, Issue 6
June 2014
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Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers
Albert Q. Lam, Benjamin S. Freedman, Ryuji Morizane, Paul H. Lerou, M. Todd Valerius, Joseph V. Bonventre
JASN Jun 2014, 25 (6) 1211-1225; DOI: 10.1681/ASN.2013080831

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Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers
Albert Q. Lam, Benjamin S. Freedman, Ryuji Morizane, Paul H. Lerou, M. Todd Valerius, Joseph V. Bonventre
JASN Jun 2014, 25 (6) 1211-1225; DOI: 10.1681/ASN.2013080831
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  • Human iPSC-derived renal cells change their immunogenic properties during maturation: Implications for regenerative therapies
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  • Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways
  • Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells
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