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About the Cover

August 2014; Volume 25,Issue 8

Looking for COVID information? All ASN Journal COVID articles are in the COVID-19 Research Collection or the COVID-19 In Context Collection. All articles are free.​

Cover image

Scheme of miR-29a signaling protection against diabetes-induced podocyte injury and renal dysfunction. miR-29a signaling attenuated the promoting effects of hyperglycemia on HDAC4-dependent nephrin deacetylation and ubiquitination and WT-1 integrity loss that accelerated podocyte apoptosis, proteinuria and renal fibrosis. HDAC4 modulation of H3K9 hypoacetylation impeded miR-29a transcription in high glucose-stressed podocytes. Solid and dashed arrow respectively indicates promoting and inhibitory reaction; Ac, acetylation; Ub, ubiquitination. Chun-Liang Lin, Chang Gung Memorial Hospital, Taiwan

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In this issue

Journal of the American Society of Nephrology: 25 (8)
Journal of the American Society of Nephrology
Vol. 25, Issue 8
August 2014
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Issue highlights

  • CSF-1 suppresses formation of renal crystals
  • Cleaved polycystin-1 activates Src
  • Wnt inhibitors contribute to CKD-MBD
  • Complement and podocyte injury in hemolytic uremic syndrome
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Print ISSN - 1046-6673 Online ISSN - 1533-3450

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