Heterogeneous Genetic Alterations in Sporadic Nephrotic Syndrome Associate with Resistance to Immunosuppression

*Department of Biomedical Experimental and Clinical Sciences “Mario Serio,” and

†Medical Genetics and

*Department of Biomedical Experimental and Clinical Sciences “Mario Serio,” and

†Medical Genetics and

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

†Medical Genetics and

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

§Department of Pediatrics, University of Padua, Padua, Italy; and

‖Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, Pavia, Italy

§Department of Pediatrics, University of Padua, Padua, Italy; and

¶Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), University of Florence, Florence, Italy;

¶Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), University of Florence, Florence, Italy;

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

*Department of Biomedical Experimental and Clinical Sciences “Mario Serio,” and

‡Pediatric Nephrology Units, Meyer Children’s University Hospital, Florence, Italy;

¶Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), University of Florence, Florence, Italy;