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Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy

Li Zhu, Ya-Ling Zhai, Feng-Mei Wang, Ping Hou, Ji-Cheng Lv, Da-Min Xu, Su-Fang Shi, Li-Jun Liu, Feng Yu, Ming-Hui Zhao, Jan Novak, Ali G. Gharavi and Hong Zhang
JASN May 2015, 26 (5) 1195-1204; DOI: https://doi.org/10.1681/ASN.2014010096
Li Zhu
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Ya-Ling Zhai
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Feng-Mei Wang
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Ping Hou
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Ji-Cheng Lv
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Da-Min Xu
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Su-Fang Shi
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Li-Jun Liu
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Feng Yu
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Ming-Hui Zhao
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Jan Novak
‖Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama; and
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Ali G. Gharavi
¶Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
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Hong Zhang
*Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
†Institute of Nephrology, Peking University, Beijing, China;
‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
§Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
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Article Information

vol. 26 no. 5 1195-1204
DOI 
https://doi.org/10.1681/ASN.2014010096
PubMed 
25205734

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication January 24, 2014
  • Accepted for publication July 18, 2014
  • Published online April 30, 2015.

Article Versions

  • Earlier version (September 9, 2014 - 08:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by the American Society of Nephrology

Author Information

  1. Li Zhu*†‡§,
  2. Ya-Ling Zhai*†‡§,
  3. Feng-Mei Wang*†‡§,
  4. Ping Hou*†‡§,
  5. Ji-Cheng Lv*†‡§,
  6. Da-Min Xu*†‡§,
  7. Su-Fang Shi*†‡§,
  8. Li-Jun Liu*†‡§,
  9. Feng Yu*†‡§,
  10. Ming-Hui Zhao*†‡§,
  11. Jan Novak‖,
  12. Ali G. Gharavi¶ and
  13. Hong Zhang*†‡§
  1. *Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;
  2. †Institute of Nephrology, Peking University, Beijing, China;
  3. ‡Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;
  4. §Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China;
  5. ‖Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama; and
  6. ¶Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
  1. Correspondence:
    Dr. Hong Zhang, Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China. Email: hongzh{at}bjmu.edu.cn
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Journal of the American Society of Nephrology: 26 (5)
Journal of the American Society of Nephrology
Vol. 26, Issue 5
May 2015
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Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy
Li Zhu, Ya-Ling Zhai, Feng-Mei Wang, Ping Hou, Ji-Cheng Lv, Da-Min Xu, Su-Fang Shi, Li-Jun Liu, Feng Yu, Ming-Hui Zhao, Jan Novak, Ali G. Gharavi, Hong Zhang
JASN May 2015, 26 (5) 1195-1204; DOI: 10.1681/ASN.2014010096

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Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy
Li Zhu, Ya-Ling Zhai, Feng-Mei Wang, Ping Hou, Ji-Cheng Lv, Da-Min Xu, Su-Fang Shi, Li-Jun Liu, Feng Yu, Ming-Hui Zhao, Jan Novak, Ali G. Gharavi, Hong Zhang
JASN May 2015, 26 (5) 1195-1204; DOI: 10.1681/ASN.2014010096
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Keywords

  • IgA nephropathy
  • complement activation
  • Complement factor H
  • complement factor H receptor 3-1Δ deletion

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