Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • JASN Podcasts
    • Article Collections
    • Archives
    • Kidney Week Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Editorial Fellowship
    • Editorial Fellowship Team
    • Editorial Fellowship Application Process
  • More
    • About JASN
    • Advertising
    • Alerts
    • Feedback
    • Impact Factor
    • Reprints
    • Subscriptions
  • ASN Kidney News
  • Other
    • ASN Publications
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • ASN Publications
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • JASN Podcasts
    • Article Collections
    • Archives
    • Kidney Week Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Editorial Fellowship
    • Editorial Fellowship Team
    • Editorial Fellowship Application Process
  • More
    • About JASN
    • Advertising
    • Alerts
    • Feedback
    • Impact Factor
    • Reprints
    • Subscriptions
  • ASN Kidney News
  • Follow JASN on Twitter
  • Visit ASN on Facebook
  • Follow JASN on RSS
  • Community Forum
Clinical Research
You have accessRestricted Access

Dialysis Modalities and HDL Composition and Function

Michael Holzer, Gernot Schilcher, Sanja Curcic, Markus Trieb, Senka Ljubojevic, Tatjana Stojakovic, Hubert Scharnagl, Chantal M. Kopecky, Alexander R. Rosenkranz, Akos Heinemann and Gunther Marsche
JASN September 2015, 26 (9) 2267-2276; DOI: https://doi.org/10.1681/ASN.2014030309
Michael Holzer
*Institute of Experimental and Clinical Pharmacology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gernot Schilcher
†Clinical Division of Nephrology, Department of Internal Medicine,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sanja Curcic
*Institute of Experimental and Clinical Pharmacology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Markus Trieb
*Institute of Experimental and Clinical Pharmacology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Senka Ljubojevic
‡Clinical Division of Cardiology, Department of Internal Medicine, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tatjana Stojakovic
§Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hubert Scharnagl
§Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chantal M. Kopecky
‖Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander R. Rosenkranz
†Clinical Division of Nephrology, Department of Internal Medicine,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akos Heinemann
*Institute of Experimental and Clinical Pharmacology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gunther Marsche
*Institute of Experimental and Clinical Pharmacology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

Abstract

Lipid abnormalities may have an effect on clinical outcomes of patients on dialysis. Recent studies have indicated that HDL dysfunction is a hallmark of ESRD. In this study, we compared HDL composition and metrics of HDL functionality in patients undergoing hemodialysis (HD) or peritoneal dialysis (PD) with those in healthy controls. We detected a marked suppression of several metrics of HDL functionality in patients on HD or PD. Compositional analysis revealed that HDL from both dialysis groups shifted toward a more proinflammatory phenotype with profound alterations in the lipid moiety and protein composition. With regard to function, cholesterol efflux and anti-inflammatory and antiapoptotic functions seemed to be more severely suppressed in patients on HD, whereas HDL-associated paraoxonase activity was lowest in patients on PD. Quantification of enzyme activities involved in HDL metabolism suggested that HDL particle maturation and remodeling are altered in patients on HD or PD. In summary, our study provides mechanistic insights into the formation of dysfunctional HDL in patients with ESRD who are on HD or PD.

  • hemodialysis
  • lipids
  • peritoneal dialysis
  • cardiovascular disease
  • Copyright © 2015 by the American Society of Nephrology
View Full Text
PreviousNext
Back to top

In this issue

Journal of the American Society of Nephrology: 26 (9)
Journal of the American Society of Nephrology
Vol. 26, Issue 9
September 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in JASN.
Enter multiple addresses on separate lines or separate them with commas.
Dialysis Modalities and HDL Composition and Function
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Dialysis Modalities and HDL Composition and Function
Michael Holzer, Gernot Schilcher, Sanja Curcic, Markus Trieb, Senka Ljubojevic, Tatjana Stojakovic, Hubert Scharnagl, Chantal M. Kopecky, Alexander R. Rosenkranz, Akos Heinemann, Gunther Marsche
JASN Sep 2015, 26 (9) 2267-2276; DOI: 10.1681/ASN.2014030309

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Dialysis Modalities and HDL Composition and Function
Michael Holzer, Gernot Schilcher, Sanja Curcic, Markus Trieb, Senka Ljubojevic, Tatjana Stojakovic, Hubert Scharnagl, Chantal M. Kopecky, Alexander R. Rosenkranz, Akos Heinemann, Gunther Marsche
JASN Sep 2015, 26 (9) 2267-2276; DOI: 10.1681/ASN.2014030309
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Results
    • Discussion
    • Concise Methods
    • Disclosures
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

  • Description and Outcomes of an Innovative Concurrent Hospice-Dialysis Program
  • Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD
  • Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease
Show more Clinical Research

Cited By...

  • CKD Increases Carbonylation of HDL and Is Associated with Impaired Antiaggregant Properties
  • Alteration of HDL Protein Composition with Hemodialysis Initiation
  • HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients
  • HDL in CKD--The Devil Is in the Detail
  • Google Scholar

Similar Articles

Related Articles

  • PubMed
  • Google Scholar

Keywords

  • hemodialysis
  • lipids
  • peritoneal dialysis
  • cardiovascular disease

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Annual Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Author Resources
  • Editorial Fellowship Program
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • JASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About JASN
  • JASN Email Alerts
  • JASN Key Impact Information
  • JASN Podcasts
  • JASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe to ASN Journals
  • Wolters Kluwer Partnership

© 2022 American Society of Nephrology

Print ISSN - 1046-6673 Online ISSN - 1533-3450

Powered by HighWire