Brief Communications

Kidney Function and Cerebral Blood Flow: The Rotterdam Study

Sanaz Sedaghat, Meike W. Vernooij, Elizabeth Loehrer, Francesco U.S. Mattace-Raso, Albert Hofman, Aad van der Lugt, Oscar H. Franco, Abbas Dehghan and M. Arfan Ikram
JASN March 2016, 27 (3) 715-721; DOI: https://doi.org/10.1681/ASN.2014111118

Abstract

CKD is linked with various brain disorders. Whereas brain integrity is dependent on cerebral perfusion, the association between kidney function and cerebral blood flow has yet to be determined. This study was performed in the framework of the population–based Rotterdam Study and included 2645 participants with mean age of 56.6 years (45% men). We used eGFR and albumin-to-creatinine ratio to assess kidney function and performed phase–contrast magnetic resonance imaging of basilar and carotid arteries to measure cerebral blood flow. Participants had an average (SD) eGFR of 86.3 (13.4) ml/min per 1.73 m2 and a median (interquartile range) albumin-to-creatinine ratio of 3.4 (2.2–6.1) mg/g. In age- and sex-adjusted models, a higher albumin-to-creatinine ratio was associated with lower cerebral blood flow level (difference in cerebral blood flow [milliliters per minute per 100 ml] per doubling of the albumin-to-creatinine ratio, −0.31; 95% confidence interval, −0.58 to −0.03). The association was not present after adjustment for cardiovascular risk factors (P=0.10). Each 1 SD lower eGFR was associated with 0.42 ml/min per 100 ml lower cerebral blood flow (95% confidence interval, 0.01 to 0.83) adjusted for cardiovascular risk factors. Thus, in this population-based study, we observed that lower eGFR is independently associated with lower cerebral blood flow.

Cerebrovascular diseases and dementia occur more often in patients with CKD.1 Incident rates of stroke are 1.9–7.6 times higher in patients with CKD compared with subjects without kidney disease depending on age and the population studied.2 Likewise, individuals at all stages of CKD have higher risk of developing dementia than the general population.3 An increasing body of evidence suggests that the link between impairment in kidney function and cognitive impairment is mediated through vascular mechanisms.4,5 In line with this notion, Seliger et al.5 showed that higher serum creatinine was related to vascular-type dementia rather than Alzheimer-type dementia. Intact kidney function is crucial for regulation of total blood volume and vascular tone.6 Therefore, impairments in kidney function can lead to disturbances in regulation of blood flow in organs that are critically dependent on constant and adequate blood flow, such as the brain.2 Cerebral hypoperfusion has been implicated in the development of vascular and neurodegenerative disorders of the brain.7,8 Although cerebral circulation is of great importance in control of adequate brain perfusion, previous literature suggests that systemic factors also play a role in regulation of cerebral blood flow.9 Different hemodynamic disturbances have been reported in patients with CKD.10,11 Nevertheless, it is not clear whether impaired kidney function is associated with lower cerebral blood flow in the general population. Therefore, we aimed to investigate the association between different measures of kidney function and cerebral blood flow in a population-based cohort of individuals 45 years old and older. In addition, we investigated the association between kidney function and cerebrovascular diseases (stroke or dementia) in subjects with different levels of cerebral blood flow. Table 1 presents characteristics of the study population in categories of eGFR on the basis of creatinine and cystatin C (eGFRcrcys). Participants’ characteristics on the basis of their albumin-to-creatinine values are presented in Supplemental Table 1.

View this table:
Table 1.

Population characteristics

Table 2 shows the association of measures of kidney function with cerebral blood flow. In age- and sex-adjusted models, a higher log–transformed albumin-to-creatinine ratio was associated with 0.31 ml/min per 100 ml lower cerebral blood flow (95% confidence interval [95% CI], −0.58 to −0.03). After adjusting for potential confounders in the second model, the association was not present (P=0.10). Each 1 SD higher eGFRcrcys was associated with 0.42 ml/min per 100 ml higher cerebral blood flow (95% CI, 0.01 to 0.83) after adjusting for cardiovascular risk factors. Each 1 SD higher eGFR on the basis of creatinine (eGFRcr) was associated with 0.48 ml/min per 100 ml higher cerebral blood flow (95% CI, 0.11 to 0.85). Additional adjustments did not change the association. We did not observe any association between eGFR on the basis of cystatin C (eGFRcys) and cerebral blood flow (P>0.05). Adjustments for eGFRcrcys in the analysis with the albumin-to-creatinine ratio as the determinant and albumin-to-creatinine ratio in the analyses with eGFR as determinant did not alter our findings (Table 2). The associations between kidney function markers and cerebral blood flow in different arteries were consistent (Supplemental Figure 1).

View this table:
Table 2.

Association of measures of kidney function with cerebral blood flow (ml/min per 100 ml brain volume)

We observed a linear trend between different categories of kidney function and cerebral blood flow, indicating lower cerebral blood flow in persons with worse kidney function (Figure 1). In a series of sensitivity analyses, exclusion of individuals with CKD, stroke, or dementia did not change our findings (Supplemental Figure 2).

Figure 1.
Figure 1.

Participants with worse kidney function have lower cerebral blood flow. Adjusted means and SEMs of cerebral blood flow (milliliters per minute per 100 ml) in different categories of kidney function. First category indicates eGFRcrcys>60 ml/min per 1.73 m2 and albumin-to-creatinine ratio <30 mg/g (n=2315). Second category indicates eGFRcrcys>60 ml/min per 1.73 m2 and albumin-to-creatinine ratio >30 mg/g or eGFRcrcys<60 ml/min per 1.73 m2 and albumin-to-creatinine ratio <30 mg/g (n=210). Third category indicates eGFRcrcys<60 ml/min per 1.73 m2 and albumin-to-creatinine ratio >30 mg/g (n=16). Model I is adjusted for age and sex. Model II is additionally adjusted for systolic BP, diastolic BP, body mass index, alcohol consumption, smoking, total cholesterol, HDL cholesterol, cardiovascular disease, diabetes mellitus, MMSE, antihypertensive medication, and lipid-lowering medication.

Comparing the effect estimates of age with albumin-to-creatinine ratio in relation to cerebral blood flow, we showed that doubling of the albumin-to-creatinine ratio corresponds to 1.7 years of increase in age. Likewise, each 1 SD lower eGFRcrcys in relation to cerebral blood flow corresponds to 2 years increase in age (Supplemental Table 2).

In subjects with low cerebral blood flow, each 1 SD lower eGFRcrcys was associated with higher prevalence of stroke or dementia (odds ratio, 1.62; 95% CI, 1.01 to 2.36), whereas there was not such an association in subjects with high cerebral blood flow (P for interaction =0.02). There was no difference between subjects with high or low cerebral blood flow in the association between albumin-to-creatinine ratio and higher prevalence of stroke or dementia (P for interaction =0.14) (Table 3). In addition, we observed that subjects with both low eGFRcrcys and low cerebral blood flow performed worse in cognitive tests compared with subjects with both high eGFRcrcys and cerebral blood flow (Supplemental Figure 3).

View this table:
Table 3.

Association of kidney function markers with prevalence of stroke and dementia in categories of cerebral blood flow

In this population–based cross–sectional study, we observed that lower eGFRcrcys and lower eGFRcr are independently associated with lower cerebral blood flow. The association between higher albumin-to-creatinine ratio and lower cerebral blood flow was not independent of cardiovascular factors.

Previous studies have reported a close link between kidney function and brain outcomes.3,12,13 Lee et al.,14 in a meta-analysis, showed that individuals with eGFR<60 ml/min per 1.73 m2 have a higher risk for stroke. Similarly, epidemiologic studies established a strong association between kidney function and dementia.3 Beyond clinically evident cerebrovascular disorders, prevalence of magnetic resonance imaging (MRI) –defined microvascular damages, such as cerebral microbleeds, lacunar infarcts, and white matter lesions, is higher among individuals with impaired kidney function.12 Comparing five patients on hemodialysis with six healthy individuals, Pierro et al.15 showed that blood transit time in the cerebral microcirculation is significantly longer in patients on hemodialysis. Given the important role of cerebral hypoperfusion in occurrence of brain abnormalities, in this study, we studied the association of kidney function and cerebral blood flow. In agreement with the previous evidence, we showed that worse kidney function is associated with lower levels of cerebral blood flow. We also found a more prominent association between eGFR and prevalence of stroke or dementia in participants with lower cerebral blood flow. In addition, we observed that subjects with both impaired kidney function and low cerebral blood flow have the lowest cognitive function. These findings might suggest that cerebral blood flow levels might play a role in the association of kidney function with brain outcomes. However, given the cross-sectional setting of our study, future longitudinal studies are needed to examine the potential role of cerebral blood flow in the relation between kidney function and brain outcomes.

Intact cerebral autoregulation is dependent on preservation of endothelial function and vasoreactivity.16 In subjects at risk for accelerated vascular endothelial damage, such as patients with impaired kidney function, this regulatory mechanism might fall short and put the brain at the risk of hypoperfusion.15 In line with this notion, it is reported that impaired cerebral autoregulation is related to not only cerebrovascular disorders and dementia but also, higher risk of mortality.17–19 Association between kidney function and cerebral blood flow can be explained in different ways. Brain and kidney share common traditional cardiovascular risk factors, such as hypertension and diabetes, which can lead to vascular injuries in both organs.13 Impaired kidney vascular integrity, as reflected in albuminuria, might show vascular damage in not only the kidney but also, other organs with similar vascular bed, like the brain.20 Additionally, impaired kidney function with alterations in water and electrolytes balance, vascular resistance, and promotion of chronic inflammation and sympathetic nerve over reactivity can contribute to vascular injury and endothelial dysfunction in the brain.12 Another explanation could be that accumulation of vasoactive species, such as asymmetric dimethyl arginine, in kidney impairment results in vasoconstriction of cerebral vessels, which ultimately decreases perfusion to the brain.21 Future studies are required to address the mechanisms behind the association between kidney function and brain outcomes.

We observed an association between eGFRcr and cerebral blood flow but not between eGFRcys and cerebral blood flow. This finding is in contrast to previous studies evaluating the link between kidney function and brain outcomes.5,22 For instance, in the study by Darsie et al.,22 eGFRcys shows larger effect size in relation to decline in cognitive function compared with eGFRcr. These discrepancies might suggest the role of factors independent of GFR in influencing the association between eGFRcr and cerebral blood flow.23 In addition, eGFRcys levels are reported to be more accurate in populations with lower creatinine production, such as the elderly, and people with comorbidities.24 Given the relatively young population in our study with high levels of eGFR and low prevalence of comorbidities, eGFRcr might be a better marker for evaluating kidney function. We also observed an association between the albumin-to-creatinine ratio as well as the combined eGFRcrcys equation and cerebral blood flow. eGFRcrcys measurements are reported to be more precise and perform better than either marker alone.25 However, given the high correlation between eGFRcrcys and either of the markers, it is also possible that measures of eGFRcrcys are influenced by eGFRcr levels. Previous studies showed that the range of cerebral blood flow in healthy middle–aged and older subjects is between 56 and 60 ml/min per 100 ml.26 In this study, the average value of cerebral blood flow was 58.5±9.7, which indicates that the majority of our study population had a normal cerebral blood flow. Despite our relatively young and healthy population–based sample, significant associations were observed between kidney function and cerebral blood flow. Therefore, we could expect that the magnitude of the association would be larger in patient populations.

Limitations of this study should be acknowledged. First, urinary albumin and creatinine were on the basis of a single spot urine sample, which is a common practice in the epidemiologic research setting.1,23 Second, although we adjusted the analyses for conventional cardiovascular risk factors, the potential roles of unmeasured cardiovascular risk factors cannot be excluded. Third, the cross-sectional design of this study limits our ability to infer directionality of the associations. Nevertheless, the population-based design of this study, large sample size, and availability of extensive data on various sociodemographic and cardiovascular factors, which enables us to control for several potential confounders, can be marked as the main strengths of this study.

Overall, we observed that lower eGFR, indicating worse kidney function, is independently associated with lower cerebral blood flow. Our findings extend previous literature by providing additional evidence for the vascular origin of the link between impaired kidney function and brain disorders. Understanding of these concomitant pathologies can be of importance for early detection of subjects who are at risk for developing structural and functional brain abnormalities.

Concise Methods

Population

The study was performed in the third cohort of the Rotterdam Study (2005–2009) and included 3932 participants 45 years old and older living in Ommoord, a district of Rotterdam, The Netherlands. From 3932 individuals participating in the study, cerebral blood flow using brain MRI was measured in 2956 participants, of whom 5 participants with 3 SDs higher or lower values for cerebral blood flow were excluded (mainly because of cortical infarcts or vessel occlusions). This resulted in 2951 participants, of whom 2797 participants had data on albumin-to-creatinine ratio, 2840 participants had data on serum creatinine levels, 2724 participants had data on serum cystatin C levels, and 2645 participants had data on both creatinine and cystatin C measurements (Supplemental Figure 4). The Rotterdam Study has been approved by the medical ethics committee according to the Population Study Act Rotterdam Study executed by the Ministry of Health, Welfare and Sports of The Netherlands. A written informed consent was obtained from all participants.27

Kidney Function

Serum creatinine and cystatin C were measured with an enzymatic assay method and a particle–enhanced immunonephelometric assay, respectively. Creatinine values were standardized to isotope–dilution mass spectrometry–traceable measurements. eGFR on the basis of the Chronic Kidney Disease Epidemiology Collaboration formula was calculated for eGFRcr and eGFRcys separately and both measurements combined (eGFRcrcys).25 Participants collected the first morning urine before arriving to the research center. Urine albumin and creatinine were determined by a turbidimetric method and measured by a Hitachi MODULAR P Analyzer (Roche/Hitachi Diagnostics, Mannheim, Germany).28 Albumin-to-creatinine ratio (milligrams per gram) was estimated by dividing albumin by creatinine. Because albumin-to-creatinine ratio was not normally distributed, we used log-transformed values to obtain values per doubling of the albumin-to-creatinine ratio. We added one to the untransformed values to account for those who did not have albuminuria. We defined three categories of kidney function using information from both eGFR and albumin-to-creatinine ratio. Kidney function was defined according to two criteria: eGFRcrcys>60 ml/min per 1.73 m2 and albumin-to-creatinine ratio <30 mg/g.23 The first category included participants who met both criteria. Participants who met only one criterion were categorized to the second category, and participants included in the third category met none of the criteria.

Cerebral Blood Flow

MRI of the brain was performed on a 1.5-T MRI scanner (Signa Excite II; General Electric Healthcare, Milwaukee, WI).29 An eight–channel head coil was used for reception of the signal. For flow measurement, two–dimensional phase–contrast imaging was performed.29 A sagittal two–dimensional phase–contrast MRI angiographic scout image was performed (repetition time=24 ms, echo time=9 ms, field of view=32 cm2, matrix=256; 160, flip angle=101, number of excitations=1, bandwidth=8.06 kHz, velocity encoding=60 cm/s, and slice thickness=60 mm). Acquisition time was 12 seconds. On this scout image, a transverse imaging plane perpendicular to both the precavernous portion of the internal carotid arteries and the middle part of the basilar artery was chosen for a two–dimensional gradient–echo phase–contrast sequence (repetition time=20 ms, echo time=4 ms, field of view=19 cm2, matrix=256; 160, flip angle=81, number of excitations=8, bandwidth=22.73 kHz, velocity encoding=120 cm/s, and slice thickness=5 mm). Acquisition time was 51 seconds, and no cardiac gating was performed.30,31 For the assessment of brain volumes, the structural MRI scans (T1–weighted, proton density–weighted, and fluid–attenuated inversion recovery) were used. Details, including preprocessing steps and the classification algorithm, have been described elsewhere.30

Flow (in milliliters per second) was calculated by multiplying the average velocity with the cross-sectional area of the vessel.31 To calculate global cerebral blood flow (in milliliters per minute), flow rates for the carotid arteries and the basilar artery were summed and multiplied by 60 s/min. To measure parenchymal cerebral blood flow in milliliters per minute per 100 ml brain tissue, values were divided by each individual’s brain volume (milliliters), and the obtained results were multiplied by 100 (Supplemental Figure 5). Retest reliability was performed by two independent experienced technicians in 533 scans for all manual drawing around both carotids and the basilar artery and subsequent flow measurements. This showed inter-rater correlations >0.94 for all vessels, indicating an excellent agreement.29

Covariates

Information related to smoking (past/current/never) and alcohol consumption was on the basis of interviews using questionnaires. Alcohol consumers were categorized into none, moderate (<15 g/d) and heavy (>15 g/d) drinkers. Information on lipid-lowering medication and antihypertensive medication use was on the basis of home interview. Serum total and HDL cholesterol levels were measured using an automated enzymatic method. BP was measured two times in a single visit, and the average of two measurements, separated by a count of the pulse rate, was used in the analyses. History of coronary heart disease was considered as experiencing myocardial infarction or coronary revascularization procedures. Diabetes mellitus were defined by use of blood glucose–lowering medication and/or a fasting serum glucose level ≥7.0 mmol/L. Information on stroke was acquired through digital record linkage with general practitioners and medical specialists in the research area.32 To define patients with dementia, individuals with the Mini Mental State Examination (MMSE) <26 or the Geriatric Mental Schedule organic level >0 underwent an examination and informant interview with the Cambridge Examination for Mental Disorders in the Elderly. Additional neurologic testing was applied for participants who were suspected of having dementia. Covariates were selected on the basis of the previous knowledge and literature. We checked the absence of colinearity between covariates in the model using the Variance Inflation Factor. We did not observe any colinearity between the covariates included in the models.

Statistical Analyses

Associations of measures of kidney function (albumin-to-creatinine ratio, eGFRcr, eGFRcys, and eGFRcrcys) with cerebral blood flow were evaluated using multiple linear regression models. β-values and 95% CIs were estimated per 1 SD decrease for measures of kidney function. All analyses were adjusted for age and sex. Then, we further adjusted the analyses for systolic BP, diastolic BP, body mass index, alcohol consumption, smoking, total cholesterol, HDL cholesterol, MMSE, coronary heart disease, diabetes mellitus, lipid-lowering medication, and BP-lowering medications (diuretics, β-blockers, angiotensin converting enzyme inhibitors, and calcium channel blockers). In the third model, analyses with eGFRs as determinants were further adjusted for albumin-to-creatinine ratio, and analysis with albumin-to-creatinine ratio as the determinant was further adjusted for eGFRcrcys. There was no departure from linearity in the association between kidney function markers and cerebral blood flow. We performed the analysis of covariance, where adjusted mean values of cerebral blood flow were compared across three categories of kidney function. In addition, we performed a series of sensitivity analyses excluding subjects with CKD (eGFRcrcys<60 ml/min per 1.73 m2), stroke, or dementia. To explore whether the association between kidney function and cerebral blood flow was consistent between right and left carotid internal and basilar arteries, we assessed the association between kidney function measures and cerebral blood flow in different arteries separately. Furthermore, to compare the magnitude of the association with age as an established risk factor for brain disorders, we calculated the effect estimates for the association of age with cerebral blood flow. We then divided the β-values of kidney function markers by the β-value of age in relation to cerebral blood flow and reported the corresponding ratios. To investigate whether the link between kidney function and cerebrovascular diseases is mediated through lower cerebral blood flow, we evaluated the interaction between kidney function and cerebral blood flow in relation to presence of clinical stroke or clinical dementia. In addition, in the stratified analysis, we investigated the association of eGFRcrcys and albumin-to-creatinine ratio with stroke or dementia in two groups of participants with low and high cerebral blood flow. To evaluate whether subjects with both low eGFRcrcys and cerebral blood flow have worse performance in cognitive test, we calculated mean values of different cognitive domains (memory, executive function, processing speed, and motor speed) across different categories of eGFRcrcys and cerebral blood flow in individuals without dementia. Cognitive function was assessed with the following neuropsychologic test battery: the MMSE, a 15–word verbal recall learning test, the Stroop tests, the Letter–Digit Substitution Task (LDST), the Purdue Pegboard Test, and a word fluency test. The compound score for memory was the average of the z scores for the immediate and delayed recall of the 15–word verbal learning test. Executive function was constructed by averaging the z scores for the Stroop tests, the LDST, and the word fluency test. Information processing speed was the average of the z scores for the Stroop reading and Stroop color naming tests and the LDST. Details of the cognitive assessments are provided elsewhere.33 All analyses were carried out using SPSS 20.0.2 for windows or R version 2.15.0.

Disclosures

O.H.F. works in ErasmusAGE, a center for aging research across the life course funded by Nestlé Nutrition (Nestec Ltd.), Metagenics Inc., and AXA.

Acknowledgments

The Rotterdam Study investigators thank the participants and staff from the Rotterdam Study, the participating general practitioners, and the pharmacists.

The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University Rotterdam; The Netherlands Organization for Scientific Research; The Netherlands Organization for Health Research and Development; the Research Institute for Diseases in the Elderly; the Ministry of Education, Culture and Science; the Ministry of Health, Welfare and Sports; the European Commission; and the Municipality of Rotterdam. A.D. is supported by Nederlandse Organisatie voor Wetenschappelijk Onderzoek Grant veni, 916.12.154 and the Erasmus Universiteit Rotterdam Fellowship.

Nestlé Nutrition (Nestec Ltd.), Metagenics Inc., and AXA had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

Footnotes

References

  1. ↵
    1. Toyoda K,
    2. Ninomiya T
    : Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol 13: 823–833, 2014pmid:25030514
    OpenUrlCrossRefPubMed
  2. ↵
    1. Schiller A,
    2. Covic A
    : Kidney and brain—a renal perspective of ‘Les Liaisons Dangereuses’. Nephrol Dial Transplant 25: 1370–1373, 2010pmid:20167572
    OpenUrlCrossRefPubMed
  3. ↵
    1. Bugnicourt JM,
    2. Godefroy O,
    3. Chillon JM,
    4. Choukroun G,
    5. Massy ZA
    : Cognitive disorders and dementia in CKD: The neglected kidney-brain axis. J Am Soc Nephrol 24: 353–363, 2013pmid:23291474
    OpenUrlAbstract/FREE Full Text
  4. ↵
    1. Helmer C,
    2. Stengel B,
    3. Metzger M,
    4. Froissart M,
    5. Massy ZA,
    6. Tzourio C,
    7. Berr C,
    8. Dartigues JF
    : Chronic kidney disease, cognitive decline, and incident dementia: The 3C Study. Neurology 77: 2043–2051, 2011pmid:22116945
    OpenUrlCrossRefPubMed
  5. ↵
    1. Seliger SL,
    2. Siscovick DS,
    3. Stehman-Breen CO,
    4. Gillen DL,
    5. Fitzpatrick A,
    6. Bleyer A,
    7. Kuller LH
    : Moderate renal impairment and risk of dementia among older adults: The Cardiovascular Health Cognition Study. J Am Soc Nephrol 15: 1904–1911, 2004pmid:15213280
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Levey AS,
    2. Coresh J
    : Chronic kidney disease. Lancet 379: 165–180, 2012pmid:21840587
    OpenUrlCrossRefPubMed
  7. ↵
    1. Fiehler J,
    2. von Bezold M,
    3. Kucinski T,
    4. Knab R,
    5. Eckert B,
    6. Wittkugel O,
    7. Zeumer H,
    8. Röther J
    : Cerebral blood flow predicts lesion growth in acute stroke patients. Stroke 33: 2421–2425, 2002pmid:12364732
    OpenUrlAbstract/FREE Full Text
  8. ↵
    1. Sabayan B,
    2. Jansen S,
    3. Oleksik AM,
    4. van Osch MJ,
    5. van Buchem MA,
    6. van Vliet P,
    7. de Craen AJ,
    8. Westendorp RG
    : Cerebrovascular hemodynamics in Alzheimer’s disease and vascular dementia: A meta-analysis of transcranial Doppler studies. Ageing Res Rev 11: 271–277, 2012pmid:22226802
    OpenUrlCrossRefPubMed
  9. ↵
    1. Brown MM,
    2. Marshall J
    : Regulation of cerebral blood flow in response to changes in blood viscosity. Lancet 1: 604–609, 1985pmid:2857947
    OpenUrlCrossRefPubMed
  10. ↵
    1. Postiglione A,
    2. Faccenda F,
    3. Gallotta G,
    4. Rubba P,
    5. Federico S
    : Changes in middle cerebral artery blood velocity in uremic patients after hemodialysis. Stroke 22: 1508–1511, 1991pmid:1962325
    OpenUrlAbstract/FREE Full Text
  11. ↵
    1. Kuwabara Y,
    2. Sasaki M,
    3. Hirakata H,
    4. Koga H,
    5. Nakagawa M,
    6. Chen T,
    7. Kaneko K,
    8. Masuda K,
    9. Fujishima M
    : Cerebral blood flow and vasodilatory capacity in anemia secondary to chronic renal failure. Kidney Int 61: 564–569, 2002pmid:11849397
    OpenUrlCrossRefPubMed
  12. ↵
    1. Ikram MA,
    2. Vernooij MW,
    3. Hofman A,
    4. Niessen WJ,
    5. van der Lugt A,
    6. Breteler MM
    : Kidney function is related to cerebral small vessel disease. Stroke 39: 55–61, 2008pmid:18048865
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Mogi M,
    2. Horiuchi M
    : Clinical interaction between brain and kidney in small vessel disease. Cardiol Res Pract 2011: 306189, 2011pmid:21274446
    OpenUrlCrossRefPubMed
  14. ↵
    1. Lee M,
    2. Saver JL,
    3. Chang KH,
    4. Liao HW,
    5. Chang SC,
    6. Ovbiagele B
    : Low glomerular filtration rate and risk of stroke: Meta-analysis. BMJ 341: c4249, 2010pmid:20884696
    OpenUrlAbstract/FREE Full Text
  15. ↵
    1. Pierro ML,
    2. Kainerstorfer JM,
    3. Civiletto A,
    4. Weiner DE,
    5. Sassaroli A,
    6. Hallacoglu B,
    7. Fantini S
    : Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: A coherent hemodynamics spectroscopy study. J Biomed Opt 19: 026005, 2014pmid:24522805
    OpenUrlCrossRefPubMed
  16. ↵
    1. Lavi S,
    2. Gaitini D,
    3. Milloul V,
    4. Jacob G
    : Impaired cerebral CO2 vasoreactivity: Association with endothelial dysfunction. Am J Physiol Heart Circ Physiol 291: H1856–H1861, 2006pmid:16766649
    OpenUrlCrossRefPubMed
  17. ↵
    1. Poels MM,
    2. Ikram MA,
    3. Vernooij MW,
    4. Krestin GP,
    5. Hofman A,
    6. Niessen WJ,
    7. van der Lugt A,
    8. Breteler MM
    : Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study. J Cereb Blood Flow Metab 28: 1652–1655, 2008pmid:18575459
    OpenUrlCrossRefPubMed
    1. Jennings JR,
    2. Heim AF,
    3. Kuan DC,
    4. Gianaros PJ,
    5. Muldoon MF,
    6. Manuck SB
    : Use of total cerebral blood flow as an imaging biomarker of known cardiovascular risks. Stroke 44: 2480–2485, 2013pmid:23881956
    OpenUrlAbstract/FREE Full Text
  19. ↵
    1. Sabayan B,
    2. van der Grond J,
    3. Westendorp RG,
    4. Jukema JW,
    5. Ford I,
    6. Buckley BM,
    7. Sattar N,
    8. van Osch MJ,
    9. van Buchem MA,
    10. de Craen AJ
    : Total cerebral blood flow and mortality in old age: A 12-year follow-up study. Neurology 81: 1922–1929, 2013pmid:24174588
    OpenUrlAbstract/FREE Full Text
  20. ↵
    1. Thompson CS,
    2. Hakim AM
    : Living beyond our physiological means: Small vessel disease of the brain is an expression of a systemic failure in arteriolar function: A unifying hypothesis. Stroke 40: e322–e330, 2009pmid:19228835
    OpenUrlAbstract/FREE Full Text
  21. ↵
    1. Zoccali C,
    2. Benedetto FA,
    3. Maas R,
    4. Mallamaci F,
    5. Tripepi G,
    6. Malatino LS,
    7. Böger R,
    8. CREED Investigators
    : Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol 13: 490–496, 2002pmid:11805179
    OpenUrlAbstract/FREE Full Text
  22. ↵
    1. Darsie B,
    2. Shlipak MG,
    3. Sarnak MJ,
    4. Katz R,
    5. Fitzpatrick AL,
    6. Odden MC
    : Kidney function and cognitive health in older adults: The Cardiovascular Health Study. Am J Epidemiol 180: 68–75, 2014pmid:24844846
    OpenUrlCrossRefPubMed
  23. ↵
    1. Mahmoodi BK,
    2. Yatsuya H,
    3. Matsushita K,
    4. Sang Y,
    5. Gottesman RF,
    6. Astor BC,
    7. Woodward M,
    8. Longstreth WT Jr.,
    9. Psaty BM,
    10. Shlipak MG,
    11. Folsom AR,
    12. Gansevoort RT,
    13. Coresh J
    : Association of kidney disease measures with ischemic versus hemorrhagic strokes: Pooled analyses of 4 prospective community-based cohorts. Stroke 45: 1925–1931, 2014pmid:24876078
    OpenUrlAbstract/FREE Full Text
  24. ↵
    1. Rule AD,
    2. Bergstralh EJ,
    3. Slezak JM,
    4. Bergert J,
    5. Larson TS
    : Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int 69: 399–405, 2006pmid:16408133
    OpenUrlCrossRefPubMed
  25. ↵
    1. Inker LA,
    2. Schmid CH,
    3. Tighiouart H,
    4. Eckfeldt JH,
    5. Feldman HI,
    6. Greene T,
    7. Kusek JW,
    8. Manzi J,
    9. Van Lente F,
    10. Zhang YL,
    11. Coresh J,
    12. Levey AS,
    13. CKD-EPI Investigators
    : Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367: 20–29, 2012pmid:22762315
    OpenUrlCrossRefPubMed
  26. ↵
    1. Zarrinkoob L,
    2. Ambarki K,
    3. Wåhlin A,
    4. Birgander R,
    5. Eklund A,
    6. Malm J
    : Blood flow distribution in cerebral arteries. J Cereb Blood Flow Metab 35: 648–654, 2015pmid:25564234
    OpenUrlCrossRefPubMed
  27. ↵
    1. Hofman A,
    2. Darwish Murad S,
    3. van Duijn CM,
    4. Franco OH,
    5. Goedegebure A,
    6. Ikram MA,
    7. Klaver CC,
    8. Nijsten TE,
    9. Peeters RP,
    10. Stricker BH,
    11. Tiemeier HW,
    12. Uitterlinden AG,
    13. Vernooij MW
    : The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol 28: 889–926, 2013pmid:24258680
    OpenUrlCrossRefPubMed
  28. ↵
    1. Rietveld I,
    2. Hofman A,
    3. Pols HA,
    4. van Duijn CM,
    5. Lamberts SW,
    6. Janssen JA
    : An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance. Eur J Endocrinol 154: 715–721, 2006pmid:16645019
    OpenUrlAbstract/FREE Full Text
  29. ↵
    1. Vernooij MW,
    2. van der Lugt A,
    3. Ikram MA,
    4. Wielopolski PA,
    5. Vrooman HA,
    6. Hofman A,
    7. Krestin GP,
    8. Breteler MM
    : Total cerebral blood flow and total brain perfusion in the general population: The Rotterdam Scan Study. J Cereb Blood Flow Metab 28: 412–419, 2008pmid:17622253
    OpenUrlCrossRefPubMed
  30. ↵
    1. Ikram MA,
    2. Vrooman HA,
    3. Vernooij MW,
    4. van der Lijn F,
    5. Hofman A,
    6. van der Lugt A,
    7. Niessen WJ,
    8. Breteler MM
    : Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiol Aging 29: 882–890, 2008pmid:17239994
    OpenUrlCrossRefPubMed
  31. ↵
    1. Spilt A,
    2. Box FM,
    3. van der Geest RJ,
    4. Reiber JH,
    5. Kunz P,
    6. Kamper AM,
    7. Blauw GJ,
    8. van Buchem MA
    : Reproducibility of total cerebral blood flow measurements using phase contrast magnetic resonance imaging. J Magn Reson Imaging 16: 1–5, 2002pmid:12112496
    OpenUrlCrossRefPubMed
  32. ↵
    1. Wieberdink RG,
    2. Ikram MA,
    3. Hofman A,
    4. Koudstaal PJ,
    5. Breteler MM
    : Trends in stroke incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008. Eur J Epidemiol 27: 287–295, 2012pmid:22426770
    OpenUrlCrossRefPubMed
  33. ↵
    1. Vernooij MW,
    2. Ikram MA,
    3. Vrooman HA,
    4. Wielopolski PA,
    5. Krestin GP,
    6. Hofman A,
    7. Niessen WJ,
    8. Van der Lugt A,
    9. Breteler MM
    : White matter microstructural integrity and cognitive function in a general elderly population. Arch Gen Psychiatry 66: 545–553, 2009pmid:19414714
    OpenUrlCrossRefPubMed
Back to top

In this issue

View Selected Citations (0)
Print
Download PDF
Email Article
Citation Tools
Request Permissions
Kidney Function and Cerebral Blood Flow: The Rotterdam Study
Sanaz Sedaghat, Meike W. Vernooij, Elizabeth Loehrer, Francesco U.S. Mattace-Raso, Albert Hofman, Aad van der Lugt, Oscar H. Franco, Abbas Dehghan, M. Arfan Ikram
JASN Mar 2016, 27 (3) 715-721; DOI: 10.1681/ASN.2014111118
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Jump to section

Keywords