Journal of the American Society of Nephrology: 27 (9)

September 2016; Volume 27,Issue 9

This Month's Highlights

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This Month's Highlights
JASN September 2016, 27 (9) i; DOI: https://doi.org/10.1681/ASN.2016050579

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Up Front Matters

Editorials
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  Receptor Protein Tyrosine Phosphatase γ, CO₂ Sensing in Proximal Tubule and Acid Base Homeostasis
  Manoocher Soleimani
  
  JASN September 2016, 27 (9) 2543-2545; DOI: https://doi.org/10.1681/ASN.2016030332
  
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  Glucocorticoid-Regulated Kinase: Linking Azotemia and Muscle Wasting in CKD
  Madhav C. Menon and John Cijiang He
  
  JASN September 2016, 27 (9) 2545-2547; DOI: https://doi.org/10.1681/ASN.2016030284
  
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  Challenges in Rare Variant Association Studies for Complex Kidney Traits: CFHR5 and IgA Nephropathy
  Krzysztof Kiryluk
  
  JASN September 2016, 27 (9) 2547-2551; DOI: https://doi.org/10.1681/ASN.2016040383
  
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  The Search for a Biomarker of Relapse in ANCA-Associated Vasculitis
  Meghan E. Free and Ronald J. Falk
  
  JASN September 2016, 27 (9) 2551-2553; DOI: https://doi.org/10.1681/ASN.2016030347
  
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Brief Reviews
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  Coordinated Control of ENaC and Na⁺,K⁺-ATPase in Renal Collecting Duct
  Eric Feraille and Eva Dizin
  
  JASN September 2016, 27 (9) 2554-2563; DOI: https://doi.org/10.1681/ASN.2016020124
  
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  Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease
  Hans-Joachim Anders
  
  JASN September 2016, 27 (9) 2564-2575; DOI: https://doi.org/10.1681/ASN.2016020177
  
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  Social Determinants of Racial Disparities in CKD
  Jenna M. Norton, Marva M. Moxey-Mims, Paul W. Eggers, Andrew S. Narva, Robert A. Star, Paul L. Kimmel and Griffin P. Rodgers
  
  JASN September 2016, 27 (9) 2576-2595; DOI: https://doi.org/10.1681/ASN.2016010027
  
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Brief Communications

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MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy
Binghai Zhao, Hongzhi Li, Jieting Liu, Pengfei Han, Chunlei Zhang, He Bai, Xiaohuan Yuan, Xiaoli Wang, Li Li, Hongchuang Ma, Xiudong Jin and Yanhui Chu

JASN September 2016, 27 (9) 2597-2608; DOI: https://doi.org/10.1681/ASN.2015030300

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Recombinant N–Terminal Slit2 Inhibits TGF-β–Induced Fibroblast Activation and Renal Fibrosis
Darren A. Yuen, Yi-Wei Huang, Guang-Ying Liu, Sajedabanu Patel, Fei Fang, Joyce Zhou, Kerri Thai, Ahmad Sidiqi, Stephen G. Szeto, Lauren Chan, Mingliang Lu, Xiaolin He, Rohan John, Richard E. Gilbert, James W. Scholey and Lisa A. Robinson

JASN September 2016, 27 (9) 2609-2615; DOI: https://doi.org/10.1681/ASN.2015040356

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Role of Receptor Protein Tyrosine Phosphatase γ in Sensing Extracellular CO₂ and HCO₃⁻
Yuehan Zhou, Lara A. Skelton, Lumei Xu, Margaret P. Chandler, Jessica M. Berthiaume and Walter F. Boron

JASN September 2016, 27 (9) 2616-2621; DOI: https://doi.org/10.1681/ASN.2015040439

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IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy
Sebastian M. Lechner, Lilia Abbad, Erwan Boedec, Christina Papista, Marie-Bénédicte Le Stang, Christelle Moal, Julien Maillard, Agnès Jamin, Julie Bex-Coudrat, Yong Wang, Aiqun Li, Paolo G.V. Martini, Renato C. Monteiro and Laureline Berthelot

JASN September 2016, 27 (9) 2622-2629; DOI: https://doi.org/10.1681/ASN.2015080856

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Basic Research

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Inhibition of EGF Receptor Blocks the Development and Progression of Peritoneal Fibrosis
Li Wang, Na Liu, Chongxiang Xiong, Liuqing Xu, Yingfeng Shi, Andong Qiu, Xiujuan Zang, Haiping Mao and Shougang Zhuang

JASN September 2016, 27 (9) 2631-2644; DOI: https://doi.org/10.1681/ASN.2015030299

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Far Upstream Element-Binding Protein 1 Binds the 3′ Untranslated Region of PKD2 and Suppresses Its Translation
Wang Zheng, Fan Shen, Ruikun Hu, Birbickram Roy, JungWoo Yang, Qian Wang, Fan Zhang, Jennifer C. King, Consolato Sergi, Song-Mei Liu, Emmanuelle Cordat, Jingfeng Tang, Ying Cao, Declan Ali and Xing-Zhen Chen

JASN September 2016, 27 (9) 2645-2657; DOI: https://doi.org/10.1681/ASN.2015070836

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Tubular Epithelial NF-κB Activity Regulates Ischemic AKI
Lajos Markó, Emilia Vigolo, Christian Hinze, Joon-Keun Park, Giulietta Roël, András Balogh, Mira Choi, Anne Wübken, Jimmi Cording, Ingolf E. Blasig, Friedrich C. Luft, Claus Scheidereit, Kai M. Schmidt-Ott, Ruth Schmidt-Ullrich and Dominik N. Müller

JASN September 2016, 27 (9) 2658-2669; DOI: https://doi.org/10.1681/ASN.2015070748

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A Novel Extrinsic Pathway for the Unfolded Protein Response in the Kidney
Iadh Mami, Quentin Tavernier, Nicolas Bouvier, Rim Aboukamis, Geoffroy Desbuissons, Marion Rabant, Virginie Poindessous, Pierre Laurent-Puig, Philippe Beaune, Pierre-Louis Tharaux, Eric Thervet, Eric Chevet, Dany Anglicheau and Nicolas Pallet

JASN September 2016, 27 (9) 2670-2683; DOI: https://doi.org/10.1681/ASN.2015060703

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Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD
Kanae Yamamoto-Nonaka, Masato Koike, Katsuhiko Asanuma, Miyuki Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Teruo Hidaka, Koichiro Ichimura, Tatsuo Sakai, Norihiro Tada, Takashi Ueno, Yasuo Uchiyama and Yasuhiko Tomino

JASN September 2016, 27 (9) 2685-2700; DOI: https://doi.org/10.1681/ASN.2015040366

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Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells
Madhusudan Venkatareddy, Rakesh Verma, Anne Kalinowski, Sanjeevkumar R. Patel, Assia Shisheva and Puneet Garg

JASN September 2016, 27 (9) 2702-2719; DOI: https://doi.org/10.1681/ASN.2015050555

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Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects against Hemoglobin–Mediated Kidney Injury
Rachel P.L. van Swelm, Jack F.M. Wetzels, Vivienne G.M. Verweij, Coby M.M. Laarakkers, Jeanne C.L.M. Pertijs, Jenny van der Wijst, Frank Thévenod, Rosalinde Masereeuw and Dorine W. Swinkels

JASN September 2016, 27 (9) 2720-2732; DOI: https://doi.org/10.1681/ASN.2015040461

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Dynamin–Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy
Bernard A. Ayanga, Shawn S. Badal, Yin Wang, Daniel L. Galvan, Benny H. Chang, Paul T. Schumacker and Farhad R. Danesh

JASN September 2016, 27 (9) 2733-2747; DOI: https://doi.org/10.1681/ASN.2015101096

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IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition
Zeliha Oruc, Christelle Oblet, Ahmed Boumediene, Anne Druilhe, Virginie Pascal, Elisabeth Le Rumeur, Armelle Cuvillier, Chahrazed El Hamel, Sandrine Lecardeur, Tomas Leanderson, Willy Morelle, Jocelyne Demengeot, Jean-Claude Aldigier and Michel Cogné

JASN September 2016, 27 (9) 2748-2761; DOI: https://doi.org/10.1681/ASN.2015080911

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Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells
Fanny Oliveira Arcolino, Silvia Zia, Katharina Held, Elli Papadimitriou, Koen Theunis, Benedetta Bussolati, Anke Raaijmakers, Karel Allegaert, Thierry Voet, Jan Deprest, Joris Vriens, Jaan Toelen, Lambertus van den Heuvel and Elena Levtchenko

JASN September 2016, 27 (9) 2762-2770; DOI: https://doi.org/10.1681/ASN.2015060664

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TRPC6 G757D Loss-of-Function Mutation Associates with FSGS
Marc Riehle, Anja K. Büscher, Björn-Oliver Gohlke, Mario Kaßmann, Maria Kolatsi-Joannou, Jan H. Bräsen, Mato Nagel, Jan U. Becker, Paul Winyard, Peter F. Hoyer, Robert Preissner, Dietmar Krautwurst, Maik Gollasch, Stefanie Weber and Christian Harteneck

JASN September 2016, 27 (9) 2771-2783; DOI: https://doi.org/10.1681/ASN.2015030318

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MicroRNA-489 Induction by Hypoxia–Inducible Factor–1 Protects against Ischemic Kidney Injury
Qingqing Wei, Yong Liu, Pengyuan Liu, Jielu Hao, Mingyu Liang, Qing-sheng Mi, Jian-Kang Chen and Zheng Dong

JASN September 2016, 27 (9) 2784-2796; DOI: https://doi.org/10.1681/ASN.2015080870

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Serum Glucocorticoid–Regulated Kinase 1 Blocks CKD–Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3
Jinlong Luo, Anlin Liang, Ming Liang, Ruohan Xia, Yasmeen Rizvi, Yun Wang and Jizhong Cheng

JASN September 2016, 27 (9) 2797-2808; DOI: https://doi.org/10.1681/ASN.2015080867

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Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho–Deficient Model
Masanobu Kawai, Saori Kinoshita, Keiichi Ozono and Toshimi Michigami

JASN September 2016, 27 (9) 2810-2824; DOI: https://doi.org/10.1681/ASN.2015040446

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Clinical Epidemiology

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The Risk of Major Hemorrhage with CKD
Amber O. Molnar, Sarah E. Bota, Amit X. Garg, Ziv Harel, Ngan Lam, Eric McArthur, Gihad Nesrallah, Jeffrey Perl and Manish M. Sood

JASN September 2016, 27 (9) 2825-2832; DOI: https://doi.org/10.1681/ASN.2015050535

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Re-Examining Risk of Repeated HLA Mismatch in Kidney Transplantation
Kathryn J. Tinckam, Caren Rose, Sundaram Hariharan and John Gill

JASN September 2016, 27 (9) 2833-2841; DOI: https://doi.org/10.1681/ASN.2015060626

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Race, APOL1 Risk, and eGFR Decline in the General Population
Morgan E. Grams, Casey M. Rebholz, Yuan Chen, Andreea M. Rawlings, Michelle M. Estrella, Elizabeth Selvin, Lawrence J. Appel, Adrienne Tin and Josef Coresh

JASN September 2016, 27 (9) 2842-2850; DOI: https://doi.org/10.1681/ASN.2015070763

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Candidate Surrogate End Points for ESRD after AKI
Morgan E. Grams, Yingying Sang, Josef Coresh, Shoshana H. Ballew, Kunihiro Matsushita, Andrew S. Levey, Tom H. Greene, Miklos Z. Molnar, Zoltan Szabo, Kamyar Kalantar-Zadeh and Csaba P. Kovesdy

JASN September 2016, 27 (9) 2851-2859; DOI: https://doi.org/10.1681/ASN.2015070829

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Clinical Research

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Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD
Ian H. de Boer, Leila Zelnick, Maryam Afkarian, Ernest Ayers, Laura Curtin, Jonathan Himmelfarb, T. Alp Ikizler, Steven E. Kahn, Bryan Kestenbaum and Kristina Utzschneider

JASN September 2016, 27 (9) 2861-2871; DOI: https://doi.org/10.1681/ASN.2015070756

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Predicted Mutation Strength of Nontruncating PKD1 Mutations Aids Genotype-Phenotype Correlations in Autosomal Dominant Polycystic Kidney Disease
Christina M. Heyer, Jamie L. Sundsbak, Kaleab Z. Abebe, Arlene B. Chapman, Vicente E. Torres, Jared J. Grantham, Kyongtae T. Bae, Robert W. Schrier, Ronald D. Perrone, William E. Braun, Theodore I. Steinman, Michal Mrug, Alan S.L. Yu, Godela Brosnahan, Katharina Hopp, Maria V. Irazabal, William M. Bennett, Michael F. Flessner, Charity G. Moore, Douglas Landsittel, Peter C. Harris and for the HALT PKD and CRISP Investigators

JASN September 2016, 27 (9) 2872-2884; DOI: https://doi.org/10.1681/ASN.2015050583

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Renal Function Profile in White Kidney Donors: The First 4 Decades
Hassan N. Ibrahim, Robert N. Foley, Scott A. Reule, Richard Spong, Aleksandra Kukla, Naim Issa, Danielle M. Berglund, Gretchen K. Sieger and Arthur J. Matas

JASN September 2016, 27 (9) 2885-2893; DOI: https://doi.org/10.1681/ASN.2015091018

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Rare Variants in the Complement Factor H–Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy
Ya-Ling Zhai, Si-Jun Meng, Li Zhu, Su-Fang Shi, Su-Xia Wang, Li-Jun Liu, Ji-Cheng Lv, Feng Yu, Ming-Hui Zhao and Hong Zhang

JASN September 2016, 27 (9) 2894-2905; DOI: https://doi.org/10.1681/ASN.2015010012

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Urinary Soluble CD163 in Active Renal Vasculitis
Vincent P. O’Reilly, Limy Wong, Claire Kennedy, Louise A. Elliot, Shane O’Meachair, Alice Marie Coughlan, Eoin C. O’Brien, Michelle M. Ryan, Diego Sandoval, Emma Connolly, Gerjan J. Dekkema, Jiaying Lau, Wayel H. Abdulahad, Jan-Stephan F. Sanders, Peter Heeringa, Colm Buckley, Cathal O’Brien, Stephen Finn, Clemens D. Cohen, Maja T. Lindemeyer, Fionnuala B. Hickey, Paul V. O’Hara, Conleth Feighery, Sarah M. Moran, George Mellotte, Michael R. Clarkson, Anthony J. Dorman, Patrick T. Murray and Mark A. Little

JASN September 2016, 27 (9) 2906-2916; DOI: https://doi.org/10.1681/ASN.2015050511

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Errata

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Erratum
JASN September 2016, 27 (9) 2917; DOI: https://doi.org/10.1681/ASN.2016030339

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Erratum
JASN September 2016, 27 (9) 2918; DOI: https://doi.org/10.1681/ASN.2016060616

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This Month's Highlights

Up Front Matters

Editorials

Brief Reviews

Brief Communications

Basic Research

Clinical Epidemiology

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