Journal of the American Society of Nephrology: 28 (1)

January 2017; Volume 28,Issue 1

This Month’s Highlights

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This Month's Highlights
JASN January 2017, 28 (1) i; DOI: https://doi.org/10.1681/ASN.2016101071

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Up Front Matters

Editorials
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  Specialized Regulatory T Cells for Optimal Suppression of T Cell Responses in GN
  Kathrin Eller and Alexander R. Rosenkranz
  
  JASN January 2017, 28 (1) 1-2; DOI: https://doi.org/10.1681/ASN.2016070785
  
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  mTOR: Pumping Nutrients into Tubules
  Ken Inoki
  
  JASN January 2017, 28 (1) 3-5; DOI: https://doi.org/10.1681/ASN.2016080924
  
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  Is Dietary Red Meat Kidney Toxic?
  Nimrit Goraya and Donald E. Wesson
  
  JASN January 2017, 28 (1) 5-7; DOI: https://doi.org/10.1681/ASN.2016060664
  
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  SGLT2 Inhibitors—Sweet Success for Diabetic Kidney Disease?
  Ian H. de Boer and Steven E. Kahn
  
  JASN January 2017, 28 (1) 7-10; DOI: https://doi.org/10.1681/ASN.2016060650
  
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Brief Reviews
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  Understanding and Communicating Medical Risks for Living Kidney Donors: A Matter of Perspective
  Krista L. Lentine and Dorry L. Segev
  
  JASN January 2017, 28 (1) 12-24; DOI: https://doi.org/10.1681/ASN.2016050571
  
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  Corticosteroids in IgA Nephropathy: Lessons from Recent Studies
  Rosanna Coppo
  
  JASN January 2017, 28 (1) 25-33; DOI: https://doi.org/10.1681/ASN.2016060647
  
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  Does Renal Repair Recapitulate Kidney Development?
  Melissa Helen Little and Pamela Kairath
  
  JASN January 2017, 28 (1) 34-46; DOI: https://doi.org/10.1681/ASN.2016070748
  
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Brief Communications

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CD8⁺ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN
Janet Chang, Peter Eggenhuizen, Kim M. O’Sullivan, Maliha A. Alikhan, Stephen R. Holdsworth, Joshua D. Ooi and A. Richard Kitching

JASN January 2017, 28 (1) 47-55; DOI: https://doi.org/10.1681/ASN.2015121356

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In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance
Martin J. Wolley, Aihua Wu, Shengxin Xu, Richard D. Gordon, Robert A. Fenton and Michael Stowasser

JASN January 2017, 28 (1) 56-63; DOI: https://doi.org/10.1681/ASN.2015111221

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Open Access
IgA1 Glycosylation Is Heritable in Healthy Twins
Hannah J. Lomax-Browne, Alessia Visconti, Charles D. Pusey, H. Terence Cook, Tim D. Spector, Matthew C. Pickering and Mario Falchi

JASN January 2017, 28 (1) 64-68; DOI: https://doi.org/10.1681/ASN.2016020184

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Exome Sequencing Discerns Syndromes in Patients from Consanguineous Families with Congenital Anomalies of the Kidneys and Urinary Tract
Asaf Vivante, Daw-Yang Hwang, Stefan Kohl, Jing Chen, Shirlee Shril, Julian Schulz, Amelie van der Ven, Ghaleb Daouk, Neveen A. Soliman, Aravind Selvin Kumar, Prabha Senguttuvan, Elijah O. Kehinde, Velibor Tasic and Friedhelm Hildebrandt

JASN January 2017, 28 (1) 69-75; DOI: https://doi.org/10.1681/ASN.2015080962

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Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD–Related Systemic Inflammation
Kirstin Andersen, Marie Sophie Kesper, Julian A. Marschner, Lukas Konrad, Mi Ryu, Santhosh Kumar VR, Onkar P. Kulkarni, Shrikant R. Mulay, Simone Romoli, Jana Demleitner, Patrick Schiller, Alexander Dietrich, Susanna Müller, Oliver Gross, Hans-Joachim Ruscheweyh, Daniel H. Huson, Bärbel Stecher and Hans-Joachim Anders

JASN January 2017, 28 (1) 76-83; DOI: https://doi.org/10.1681/ASN.2015111285

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Basic Research

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MAP17 Is a Necessary Activator of Renal Na⁺/Glucose Cotransporter SGLT2
Michael J. Coady, Abdulah El Tarazi, René Santer, Pierre Bissonnette, Louis J. Sasseville, Joaquim Calado, Yoann Lussier, Christopher Dumayne, Daniel G. Bichet and Jean-Yves Lapointe

JASN January 2017, 28 (1) 85-93; DOI: https://doi.org/10.1681/ASN.2015111282

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IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD
Jianmin Chen, Julius E. Kieswich, Fausto Chiazza, Amie J. Moyes, Thomas Gobbetti, Gareth S.D. Purvis, Daniela C.F. Salvatori, Nimesh S.A. Patel, Mauro Perretti, Adrian J. Hobbs, Massimo Collino, Muhammad M. Yaqoob and Christoph Thiemermann

JASN January 2017, 28 (1) 94-105; DOI: https://doi.org/10.1681/ASN.2015060670

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Inducible Expression of Claudin-1 in Glomerular Podocytes Generates Aberrant Tight Junctions and Proteinuria through Slit Diaphragm Destabilization
Yongfeng Gong, Abby Sunq, Robyn A. Roth and Jianghui Hou

JASN January 2017, 28 (1) 106-117; DOI: https://doi.org/10.1681/ASN.2015121324

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The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane
Wenyan Xu, Miaomiao Jin, Ruikun Hu, Hong Wang, Fan Zhang, Shiaulou Yuan and Ying Cao

JASN January 2017, 28 (1) 118-129; DOI: https://doi.org/10.1681/ASN.2015080906

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Double Knockout of the Na⁺-Driven Cl⁻/HCO₃⁻ Exchanger and Na⁺/Cl⁻ Cotransporter Induces Hypokalemia and Volume Depletion
Anne Sinning, Nikita Radionov, Francesco Trepiccione, Karen I. López-Cayuqueo, Maximilien Jayat, Stéphanie Baron, Nicolas Cornière, R. Todd Alexander, Juliette Hadchouel, Dominique Eladari, Christian A. Hübner and Régine Chambrey

JASN January 2017, 28 (1) 130-139; DOI: https://doi.org/10.1681/ASN.2015070734

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Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes
Ji-Hee Kim, Jian Xie, Kyu-Hee Hwang, Yueh-Lin Wu, Noelynn Oliver, Minseob Eom, Kyu-Sang Park, Nestor Barrezueta, In-Deok Kong, R. Paul Fracasso, Chou-Long Huang and Seung-Kuy Cha

JASN January 2017, 28 (1) 140-151; DOI: https://doi.org/10.1681/ASN.2015080888

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σ1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury
Adam Hosszu, Zsuzsanna Antal, Lilla Lenart, Judit Hodrea, Sandor Koszegi, Dora B. Balogh, Nora F. Banki, Laszlo Wagner, Adam Denes, Peter Hamar, Peter Degrell, Adam Vannay, Attila J. Szabo and Andrea Fekete

JASN January 2017, 28 (1) 152-165; DOI: https://doi.org/10.1681/ASN.2015070772

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Krüppel–Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers
Sandeep K. Mallipattu, Yiqing Guo, Monica P. Revelo, Lucia Roa-Peña, Timothy Miller, Jason Ling, Stuart J. Shankland, Agnieszka B. Bialkowska, Victoria Ly, Chelsea Estrada, Mukesh K. Jain, Yuan Lu, Avi Ma’ayan, Anita Mehrotra, Rabi Yacoub, Edward P. Nord, Robert P. Woroniecki, Vincent W. Yang and John C. He

JASN January 2017, 28 (1) 166-184; DOI: https://doi.org/10.1681/ASN.2015060672

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T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN
Anna Nosko, Malte A. Kluger, Paul Diefenhardt, Simon Melderis, Claudia Wegscheid, Gisa Tiegs, Rolf A.K. Stahl, Ulf Panzer and Oliver M. Steinmetz

JASN January 2017, 28 (1) 185-196; DOI: https://doi.org/10.1681/ASN.2015070820

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G Protein–Coupled Receptor-G–Protein βγ–Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure
Fadia A. Kamal, Joshua G. Travers, Allison E. Schafer, Qing Ma, Prasad Devarajan and Burns C. Blaxall

JASN January 2017, 28 (1) 197-208; DOI: https://doi.org/10.1681/ASN.2015080852

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The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron
J. Christopher Hennings, Olga Andrini, Nicolas Picard, Marc Paulais, Antje K. Huebner, Irma Karen Lopez Cayuqueo, Yohan Bignon, Mathilde Keck, Nicolas Cornière, David Böhm, Thomas J. Jentsch, Régine Chambrey, Jacques Teulon, Christian A. Hübner and Dominique Eladari

JASN January 2017, 28 (1) 209-217; DOI: https://doi.org/10.1681/ASN.2016010085

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Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI
Diego Martin-Sanchez, Olga Ruiz-Andres, Jonay Poveda, Susana Carrasco, Pablo Cannata-Ortiz, Maria D. Sanchez-Niño, Marta Ruiz Ortega, Jesus Egido, Andreas Linkermann, Alberto Ortiz and Ana B. Sanz

JASN January 2017, 28 (1) 218-229; DOI: https://doi.org/10.1681/ASN.2015121376

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mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells
Florian Grahammer, Suresh K. Ramakrishnan, Markus M. Rinschen, Alexey A. Larionov, Maryam Syed, Hazim Khatib, Malte Roerden, Jörn Oliver Sass, Martin Helmstaedter, Dorothea Osenberg, Lucas Kühne, Oliver Kretz, Nicola Wanner, Francois Jouret, Thomas Benzing, Ferruh Artunc, Tobias B. Huber and Franziska Theilig

JASN January 2017, 28 (1) 230-241; DOI: https://doi.org/10.1681/ASN.2015111224

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Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion
Felix Knauf, Robert B. Thomson, John F. Heneghan, Zhirong Jiang, Adedotun Adebamiro, Claire L. Thomson, Christina Barone, John R. Asplin, Marie E. Egan, Seth L. Alper and Peter S. Aronson

JASN January 2017, 28 (1) 242-249; DOI: https://doi.org/10.1681/ASN.2016030279

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Wnt7b Signaling from the Ureteric Bud Epithelium Regulates Medullary Capillary Development
LaToya Ann Roker, Katrina Nemri and Jing Yu

JASN January 2017, 28 (1) 250-259; DOI: https://doi.org/10.1681/ASN.2015111205

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Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function
Janina Staffel, Daniela Valletta, Anna Federlein, Katharina Ehm, Regine Volkmann, Andrea M. Füchsl, Ralph Witzgall, Michaela Kuhn and Frank Schweda

JASN January 2017, 28 (1) 260-277; DOI: https://doi.org/10.1681/ASN.2015070731

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Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy
Keita P. Mori, Hideki Yokoi, Masato Kasahara, Hirotaka Imamaki, Akira Ishii, Takashige Kuwabara, Kenichi Koga, Yukiko Kato, Naohiro Toda, Shoko Ohno, Koichiro Kuwahara, Tomomi Endo, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama and Kiyoshi Mori

JASN January 2017, 28 (1) 278-289; DOI: https://doi.org/10.1681/ASN.2015101168

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Clinical Epidemiology

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High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD
Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, Peter M. Nilsson, Joachim Struck, Andreas Bergmann, Olle Melander and Marju Orho-Melander

JASN January 2017, 28 (1) 291-303; DOI: https://doi.org/10.1681/ASN.2015101177

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Red Meat Intake and Risk of ESRD
Quan-Lan Jasmine Lew, Tazeen Hasan Jafar, Hiromi Wai Ling Koh, Aizhen Jin, Khuan Yew Chow, Jian-Min Yuan and Woon-Puay Koh

JASN January 2017, 28 (1) 304-312; DOI: https://doi.org/10.1681/ASN.2016030248

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The Substantial Loss of Nephrons in Healthy Human Kidneys with Aging
Aleksandar Denic, John C. Lieske, Harini A. Chakkera, Emilio D. Poggio, Mariam P. Alexander, Prince Singh, Walter K. Kremers, Lilach O. Lerman and Andrew D. Rule

JASN January 2017, 28 (1) 313-320; DOI: https://doi.org/10.1681/ASN.2016020154

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Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients
Tariq Shafi, Neil R. Powe, Timothy W. Meyer, Seungyoung Hwang, Xin Hai, Michal L. Melamed, Tanushree Banerjee, Josef Coresh and Thomas H. Hostetter

JASN January 2017, 28 (1) 321-331; DOI: https://doi.org/10.1681/ASN.2016030374

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Clinical Research

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Genome-Wide Gene Expression Profiling of Randall’s Plaques in Calcium Oxalate Stone Formers
Kazumi Taguchi, Shuzo Hamamoto, Atsushi Okada, Rei Unno, Hideyuki Kamisawa, Taku Naiki, Ryosuke Ando, Kentaro Mizuno, Noriyasu Kawai, Keiichi Tozawa, Kenjiro Kohri and Takahiro Yasui

JASN January 2017, 28 (1) 333-347; DOI: https://doi.org/10.1681/ASN.2015111271

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Rituximab for Severe Membranous Nephropathy: A 6-Month Trial with Extended Follow-Up
Karine Dahan, Hanna Debiec, Emmanuelle Plaisier, Marine Cachanado, Alexandra Rousseau, Laura Wakselman, Pierre-Antoine Michel, Fabrice Mihout, Bertrand Dussol, Marie Matignon, Christiane Mousson, Tabassome Simon and Pierre Ronco

JASN January 2017, 28 (1) 348-358; DOI: https://doi.org/10.1681/ASN.2016040449

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Premature T Cell Senescence in Pediatric CKD
Roshan P. George, Aneesh K. Mehta, Sebastian D. Perez, Pamela Winterberg, Jennifer Cheeseman, Brandi Johnson, Jean Kwun, Stephanie Monday, Linda Stempora, Barry Warshaw and Allan D. Kirk

JASN January 2017, 28 (1) 359-367; DOI: https://doi.org/10.1681/ASN.2016010053

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Open Access
Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects
Hiddo J. L. Heerspink, Mehul Desai, Meg Jardine, Dainius Balis, Gary Meininger and Vlado Perkovic

JASN January 2017, 28 (1) 368-375; DOI: https://doi.org/10.1681/ASN.2016030278

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Meta-Analysis

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AKI and Long-Term Risk for Cardiovascular Events and Mortality
Ayodele Odutayo, Christopher X. Wong, Michael Farkouh, Douglas G. Altman, Sally Hopewell, Connor A. Emdin and Benjamin H. Hunn

JASN January 2017, 28 (1) 377-387; DOI: https://doi.org/10.1681/ASN.2016010105

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Table of Contents

This Month’s Highlights

Up Front Matters

Editorials

Brief Reviews

Brief Communications

Basic Research

Clinical Epidemiology

Clinical Research

Meta-Analysis

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