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Clinical Research
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Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development

Chris Wiebe, David N. Rush, Thomas E. Nevins, Patricia E. Birk, Tom Blydt-Hansen, Ian W. Gibson, Aviva Goldberg, Julie Ho, Martin Karpinski, Denise Pochinco, Atul Sharma, Leroy Storsley, Arthur J. Matas and Peter W. Nickerson
JASN November 2017, 28 (11) 3353-3362; DOI: https://doi.org/10.1681/ASN.2017030287
Chris Wiebe
Departments of *Medicine,
†Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada;
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David N. Rush
Departments of *Medicine,
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Thomas E. Nevins
Departments of ‡Pediatrics and
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Patricia E. Birk
§Pediatrics and Child Health,
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Tom Blydt-Hansen
‖Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
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Ian W. Gibson
†Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada;
¶Pathology, and
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Aviva Goldberg
§Pediatrics and Child Health,
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Julie Ho
Departments of *Medicine,
**Immunology, University of Manitoba, Winnipeg, Manitoba, Canada;
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Martin Karpinski
Departments of *Medicine,
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Denise Pochinco
†Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada;
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Atul Sharma
§Pediatrics and Child Health,
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Leroy Storsley
Departments of *Medicine,
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Arthur J. Matas
††Surgery, University of Minnesota, Minneapolis, Minnesota; and
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Peter W. Nickerson
Departments of *Medicine,
†Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada;
**Immunology, University of Manitoba, Winnipeg, Manitoba, Canada;
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Article Information

vol. 28 no. 11 3353-3362
DOI 
https://doi.org/10.1681/ASN.2017030287
PubMed 
28729289

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication March 15, 2017
  • Accepted for publication May 15, 2017
  • Published online October 31, 2017.

Article Versions

  • Earlier version (July 20, 2017 - 07:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by the American Society of Nephrology

Author Information

  1. Chris Wiebe*†,
  2. David N. Rush*,
  3. Thomas E. Nevins‡,
  4. Patricia E. Birk§,
  5. Tom Blydt-Hansen‖,
  6. Ian W. Gibson†¶,
  7. Aviva Goldberg§,
  8. Julie Ho***,
  9. Martin Karpinski*,
  10. Denise Pochinco†,
  11. Atul Sharma§,
  12. Leroy Storsley*,
  13. Arthur J. Matas†† and
  14. Peter W. Nickerson*†**
  1. Departments of *Medicine,
  2. §Pediatrics and Child Health,
  3. ¶Pathology, and
  4. **Immunology, University of Manitoba, Winnipeg, Manitoba, Canada;
  5. †Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada;
  6. Departments of ‡Pediatrics and
  7. ††Surgery, University of Minnesota, Minneapolis, Minnesota; and
  8. ‖Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
  1. Correspondence:
    Dr. Chris Wiebe, Department of Medicine, University of Manitoba, Room 331, 777 William Avenue, Winnipeg, MB, Canada R3E3R4. Email: cwiebe{at}hsc.mb.ca

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Journal of the American Society of Nephrology: 28 (11)
Journal of the American Society of Nephrology
Vol. 28, Issue 11
November 2017
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Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development
Chris Wiebe, David N. Rush, Thomas E. Nevins, Patricia E. Birk, Tom Blydt-Hansen, Ian W. Gibson, Aviva Goldberg, Julie Ho, Martin Karpinski, Denise Pochinco, Atul Sharma, Leroy Storsley, Arthur J. Matas, Peter W. Nickerson
JASN Nov 2017, 28 (11) 3353-3362; DOI: 10.1681/ASN.2017030287

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Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development
Chris Wiebe, David N. Rush, Thomas E. Nevins, Patricia E. Birk, Tom Blydt-Hansen, Ian W. Gibson, Aviva Goldberg, Julie Ho, Martin Karpinski, Denise Pochinco, Atul Sharma, Leroy Storsley, Arthur J. Matas, Peter W. Nickerson
JASN Nov 2017, 28 (11) 3353-3362; DOI: 10.1681/ASN.2017030287
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Keywords

  • kidney transplantation
  • acute allograft rejection
  • donor specific antibody
  • human leukocyte antigen
  • tacrolimus
  • allograft survival

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