On the cover: In vivo SPECT whole-body imaging revealed relatively low-level and diffuse distribution of a systemically delivered radiolabeled TGF-β mAb (right panel), but systemic delivery of a radiolabeled FnEDA mAb (left panel) or a radiolabeled TGF-β⁺ FnEDA DVD-Ig (center panel) were both highly localized to the fibrotic kidney of mice with a unilateral ureter obstruction (UUO model). Images are oriented to show the obstructed kidney on the left side, and are maximum intensity projections (MIPs) where 3D signals are collapsed into 2D. This approach utilized a relatively disease-restricted protein of extracellular matrix (i.e., FnEDA) to “hook” an FnEDA targeting moiety of the DVD-Ig molecule and subsequently deliver a therapeutic TGF-β moiety to specifically treat diseased renal tissue and minimize systemic distribution. Steve McGaraughty, Todd Cole, Yanping Luo, AbbVie, North Chicago, Illinois