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Basic Research
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Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition

Ramon Sonneveld, Joost G. Hoenderop, Andrea M. Isidori, Carole Henique, Henry B. Dijkman, Jo H. Berden, Pierre-Louis Tharaux, Johan van der Vlag and Tom Nijenhuis
JASN May 2017, 28 (5) 1491-1505; DOI: https://doi.org/10.1681/ASN.2015080885
Ramon Sonneveld
Departments of *Nephrology,
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Joost G. Hoenderop
†Physiology, and
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Andrea M. Isidori
‡Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;
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Carole Henique
§Paris Cardiovascular Centre, Institut National de la Santé et de la Recherche Médicale, Paris, France;
‖Sorbonne Paris Cité, Université Paris Descartes, Paris, France; and
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Henry B. Dijkman
¶Pathology, Radboud University Medical Center, Nijmegen, The Netherlands;
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Jo H. Berden
Departments of *Nephrology,
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Pierre-Louis Tharaux
§Paris Cardiovascular Centre, Institut National de la Santé et de la Recherche Médicale, Paris, France;
‖Sorbonne Paris Cité, Université Paris Descartes, Paris, France; and
**Service de Néphrologie, Hôpital Européen Georges Pompidou, Paris, France
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Johan van der Vlag
Departments of *Nephrology,
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Tom Nijenhuis
Departments of *Nephrology,
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Article Information

vol. 28 no. 5 1491-1505
DOI 
https://doi.org/10.1681/ASN.2015080885
PubMed 
27895156

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication August 12, 2016
  • Accepted for publication November 2, 2016
  • Published online April 28, 2017.

Article Versions

  • Earlier version (November 28, 2016 - 07:20).
  • Earlier version (January 16, 2017 - 08:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by the American Society of Nephrology

Author Information

  1. Ramon Sonneveld*,
  2. Joost G. Hoenderop†,
  3. Andrea M. Isidori‡,
  4. Carole Henique§‖,
  5. Henry B. Dijkman¶,
  6. Jo H. Berden*,
  7. Pierre-Louis Tharaux§‖**,
  8. Johan van der Vlag* and
  9. Tom Nijenhuis*
  1. Departments of *Nephrology,
  2. †Physiology, and
  3. ¶Pathology, Radboud University Medical Center, Nijmegen, The Netherlands;
  4. ‡Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;
  5. §Paris Cardiovascular Centre, Institut National de la Santé et de la Recherche Médicale, Paris, France;
  6. ‖Sorbonne Paris Cité, Université Paris Descartes, Paris, France; and
  7. **Service de Néphrologie, Hôpital Européen Georges Pompidou, Paris, France
  1. Correspondence:
    Dr. Tom Nijenhuis, Radboud University Medical Center, Department of Nephrology (464), PO Box 9101, 6500 HB Nijmegen, The Netherlands. Email: Tom.Nijenhuis{at}Radboudumc.nl
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Journal of the American Society of Nephrology: 28 (5)
Journal of the American Society of Nephrology
Vol. 28, Issue 5
May 2017
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Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition
Ramon Sonneveld, Joost G. Hoenderop, Andrea M. Isidori, Carole Henique, Henry B. Dijkman, Jo H. Berden, Pierre-Louis Tharaux, Johan van der Vlag, Tom Nijenhuis
JASN May 2017, 28 (5) 1491-1505; DOI: 10.1681/ASN.2015080885

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Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition
Ramon Sonneveld, Joost G. Hoenderop, Andrea M. Isidori, Carole Henique, Henry B. Dijkman, Jo H. Berden, Pierre-Louis Tharaux, Johan van der Vlag, Tom Nijenhuis
JASN May 2017, 28 (5) 1491-1505; DOI: 10.1681/ASN.2015080885
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Keywords

  • albuminuria
  • ion channel
  • podocyte
  • signaling
  • glomerulosclerosis
  • focal segmental glomerulosclerosis

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