Article Figures & Data
Figures
- Figure 1.
Cumulative incidence of ESRD was lowest among living donors with BMI <25 and highest among donors with BMI>30 and it was higher among donors who were first-degree biologically related to their recipient. Incidence of ESRD is stratified separately by BMI category (A) and relatedness to recipient (B).
- Figure 2.
Among nonblack donors, older age groups had higher cumulative incidence of ESRD, whereas among black donors, older age groups had lower risk of ESRD.
- Figure 3.
Among all donors in the study, the full range of predicted risk of ESRD was wide, with median (IQR) range of 1 (1–2) cases per 10,000 donors at 5 years postdonation; 6 (4–11) per 10,000 at 10 years postdonation; 16 (10–29) per 10,000 at 15 years postdonation; and 34 (20–59) per 10,000 at 20 years postdonation. Predicted risk of postdonation ESRD for each donor was calculated on the basis of donor characteristics. The median donor had 34 per 10,000 predicted risk of ESRD at 20 years postdonation. Half of all donors have predicted risk between the two dashed lines, but 1% of donors had predicted 20-year ESRD risk exceeding 256 per 10,000.
- Figure 4.
Close calibration of observed and predicted cumulative incidence of ESRD. The calibration is stratified by sex in (A) and by race in (B). The plots show good agreement between observed and predicted values.
Tables
Characteristic No ESRD ESRD N 133,493 331 Median (IQR) yr of donation 2004 (1999–2010) 1995 (1991–2000) Median (IQR) age at donation 40 (31–48) 38 (30–48) Median (IQR) BMI at donation, kg/m2a 26.6 (23.7–29.7) 28.9 (24.4–31.4) Men, % 40.7 60.4 Black, % 12.5 34.4 First-degree biologically related to recipient, % 59.4 85.6 Sibling of recipient 29.9 46.8 Child of recipient 16.0 18.2 Parent of recipient 13.5 20.9 ↵a BMI at donation and relationship to recipient were missing for 31.0% of donors and 0.7% of donors, respectively. Missingness of BMI was primarily due to incomplete reporting before 1999. In regression analyses, multiple imputation was used to account for missing data.
Characteristic aHRa P Value Men (at age 40) 1.88 (95% CI, 1.50 to 2.35) <0.001 black race (at age 40) 2.96 (95% CI, 2.25 to 3.89) <0.001 Age per 10 yr: nonblack 1.40 (95% CI, 1.23 to 1.59) <0.001 Age per 10 yr: black 0.88 (95% CI, 0.72 to 1.09) 0.3 BMI per 5 kg/m2 1.61 (95% CI, 1.29 to 2.00) <0.001 First-degree biologically related to recipient 1.70 (95% CI, 1.24 to 2.34) <0.01 ↵a Male sex and greater BMI were associated with higher risk of ESRD (both P<0.001). Older age was associated with higher risk of ESRD in nonblack male donors (P<0.001), but the association between age and risk was not statistically significant in black donors (P=0.1). Donors who were closely related to their recipient had higher risk of ESRD (P<0.01).
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