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Up Front MattersBrief Reviews
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Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology

Norberto Perico, Federica Casiraghi and Giuseppe Remuzzi
JASN February 2018, 29 (2) 362-375; DOI: https://doi.org/10.1681/ASN.2017070781
Norberto Perico
1Department of Renal Medicine and Molecular Medicine, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy;
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Federica Casiraghi
1Department of Renal Medicine and Molecular Medicine, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy;
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Giuseppe Remuzzi
1Department of Renal Medicine and Molecular Medicine, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy;
2Unit of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy; and
3L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy
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Abstract

Mesenchymal stromal cells have emerged as potential candidates for cell-based therapies to modulate the immune response in organ transplantation and repair tissues after acute or chronic injury. Preclinical studies have shown convincingly in rodent models that mesenchymal stromal cells can prolong solid organ graft survival and that they can induce immune tolerance, accelerate recovery from AKI, and promote functional improvement in chronic nephropathies. Multiple complex properties of the cells, including immunomodulatory, anti-inflammatory, and proregenerative effects, seem to contribute. The promising preclinical studies have encouraged investigators to explore the safety, tolerability, and efficacy of mesenchymal stromal cell–based therapy in pilot clinical trials, including those for bone marrow and solid organ transplantation, autoimmune diseases, and tissue and organ repair. Here, we review the available data on culture-expanded mesenchymal stromal cells tested in renal transplantation, AKI, and CKD. We also briefly discuss the relevant issues that must be addressed to ensure rigorous assessment of the safety and efficacy of mesenchymal stromal cell therapies to allow the translation of this research into the practice of clinical nephrology.

  • mesenchymal stromal cells
  • kidney disease
  • acute kidney injury
  • Copyright © 2018 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 29 (2)
Journal of the American Society of Nephrology
Vol. 29, Issue 2
February 2018
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Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology
Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi
JASN Feb 2018, 29 (2) 362-375; DOI: 10.1681/ASN.2017070781

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Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology
Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi
JASN Feb 2018, 29 (2) 362-375; DOI: 10.1681/ASN.2017070781
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  • mesenchymal stromal cells
  • kidney disease
  • acute kidney injury

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