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Filtering the Evidence: Is There a Cognitive Cost of Hemodialysis?

Dawn F. Wolfgram
JASN April 2018, 29 (4) 1087-1089; DOI: https://doi.org/10.1681/ASN.2018010077
Dawn F. Wolfgram
1Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; and
2Section of Nephrology, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin
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    Figure 1.

    Conceptual model describing a potential mechanism of cognitive decline due to HD-associated circulatory stress and cerebral hypoperfusion. Boxes A–C depict the risk factors common to patients on dialysis that can lead to impaired cerebral autoregulation. Pairing impaired cerebral autoregulation with the circulatory stress of conventional in-center HD (box D) can lead to downstream events shown in boxes E1–3, with cognitive impairment as the outcome. Box F describes the numerous other non-HD specific factors that can also contribute to cognitive impairment.

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Journal of the American Society of Nephrology: 29 (4)
Journal of the American Society of Nephrology
Vol. 29, Issue 4
April 2018
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Filtering the Evidence: Is There a Cognitive Cost of Hemodialysis?
Dawn F. Wolfgram
JASN Apr 2018, 29 (4) 1087-1089; DOI: 10.1681/ASN.2018010077

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Filtering the Evidence: Is There a Cognitive Cost of Hemodialysis?
Dawn F. Wolfgram
JASN Apr 2018, 29 (4) 1087-1089; DOI: 10.1681/ASN.2018010077
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Keywords

  • cognitive impairment
  • cerebral perfusion
  • hemodialysis

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