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Rapid Communication
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A Novel Method for Rapid Bedside Measurement of GFR

Dana V. Rizk, Daniel Meier, Ruben M. Sandoval, Teresa Chacana, Erinn S. Reilly, Jesse C. Seegmiller, Emmanuel DeNoia, James S. Strickland, Joseph Muldoon and Bruce A. Molitoris
JASN June 2018, 29 (6) 1609-1613; DOI: https://doi.org/10.1681/ASN.2018020160
Dana V. Rizk
Nephrology Division, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;
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Daniel Meier
FAST BioMedical, Carmel, Indiana;
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Ruben M. Sandoval
FAST BioMedical, Carmel, Indiana;Nephrology Division, Department of Medicine, Indiana University, Indianapolis, Indiana;
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Teresa Chacana
Nephrology Division, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;
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Erinn S. Reilly
FAST BioMedical, Carmel, Indiana;
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Jesse C. Seegmiller
Advanced Research and Diagnostics Laboratory, University of Minnesota, Minneapolis, Minnesota; and
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Emmanuel DeNoia
ICON Early Phase Services LLC, San Antonio, Texas
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James S. Strickland
FAST BioMedical, Carmel, Indiana;
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Joseph Muldoon
FAST BioMedical, Carmel, Indiana;
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Bruce A. Molitoris
FAST BioMedical, Carmel, Indiana;Nephrology Division, Department of Medicine, Indiana University, Indianapolis, Indiana;
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Abstract

Background Direct quantitative measurement of GFR (mGFR) remains a specialized task primarily performed in research settings. Multiple formulas for estimating GFR have been developed that use the readily available endogenous biomarkers creatinine and/or cystatin C. However, eGFR formulas have limitations, and an accurate mGFR is necessary in some clinical situations and for certain patient populations. We conducted a prospective, open-label study to evaluate a novel rapid technique for determining plasma volume and mGFR.

Methods We developed a new exogenous biomarker, visible fluorescent injectate (VFI), consisting of a large 150-kD rhodamine derivative and small 5-kD fluorescein carboxymethylated dextrans. After a single intravenous injection of VFI, plasma volume and mGFR can be determined on the basis of the plasma pharmacokinetics of the rhodamine derivative and fluorescein carboxymethylated dextrans, respectively. In this study involving 32 adults with normal kidney function (n=16), CKD stage 3 (n=8), or CKD stage 4 (n=8), we compared VFI-based mGFR values with values obtained by measuring iohexol plasma disappearance. VFI-based mGFR required three 0.5-ml blood draws over 3 hours; iohexol-based mGFR required five samples taken over 6 hours. Eight healthy participants received repeat VFI injections at 24 hours.

Results VFI-based mGFR values showed close linear correlation with the iohexol-based mGFR values in all participants. Injections were well tolerated, including when given on consecutive days. No serious adverse events were reported. VFI-based mGFR was highly reproducible.

Conclusions The VFI-based approach allows for the rapid determination of mGFR at the bedside while maintaining patient safety and measurement accuracy and reproducibility.

  • Biomarker
  • FAST BioMedical
  • acute kidney injury
  • chronic kidney disease
  • fluorescent glomerular filtration rate measurement
  • kidney function
  • Copyright © 2018 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 29 (6)
Journal of the American Society of Nephrology
Vol. 29, Issue 6
June 2018
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A Novel Method for Rapid Bedside Measurement of GFR
Dana V. Rizk, Daniel Meier, Ruben M. Sandoval, Teresa Chacana, Erinn S. Reilly, Jesse C. Seegmiller, Emmanuel DeNoia, James S. Strickland, Joseph Muldoon, Bruce A. Molitoris
JASN Jun 2018, 29 (6) 1609-1613; DOI: 10.1681/ASN.2018020160

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A Novel Method for Rapid Bedside Measurement of GFR
Dana V. Rizk, Daniel Meier, Ruben M. Sandoval, Teresa Chacana, Erinn S. Reilly, Jesse C. Seegmiller, Emmanuel DeNoia, James S. Strickland, Joseph Muldoon, Bruce A. Molitoris
JASN Jun 2018, 29 (6) 1609-1613; DOI: 10.1681/ASN.2018020160
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Keywords

  • biomarker
  • FAST BioMedical
  • acute kidney injury
  • chronic kidney disease
  • fluorescent glomerular filtration rate measurement
  • kidney function

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