Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

2Department of Pediatric Nephrology, Institute for Mother and Child Health Care, Belgrade, Serbia;

2Department of Pediatric Nephrology, Institute for Mother and Child Health Care, Belgrade, Serbia;

3Department of Pediatrics, Center of Pediatric Nephrology and Transplantation, Cairo University, Egypt;

4Egyptian Group for Orphan Renal Diseases, Cairo, Egypt;

5Department of Pediatrics and

6Pediatric Nephrology Center of Excellence, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia;

5Department of Pediatrics and

6Pediatric Nephrology Center of Excellence, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia;

7Pediatric Nephrology Unit, University of Alexandria, Alexandria, Egypt;

8University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

9United Arab Emirates University, Abu Dhabi, United Arab Emirates;

10Pediatric Nephrology Department, Dubai Kidney Center Of Excellence, Dubai Hospital, Dubai, United Arab Emirates;

10Pediatric Nephrology Department, Dubai Kidney Center Of Excellence, Dubai Hospital, Dubai, United Arab Emirates;

11Department of Pediatric Nephrology, Institute of Child Health and Hospital for Children, The Tamil Nadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India;

12Department of Pediatric Nephrology, Dr. Mehta’s Multi-Specialty Hospital, Chennai, Tamil Nadu, India;

13Division of Nephrology, Columbia University, New York, New York;

14Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts;

14Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts;

15Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts;

14Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts;

15Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts;

15Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts;

15Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts;

16Department of Genetics, Yale University School of Medicine, New Haven, Connecticut;

16Department of Genetics, Yale University School of Medicine, New Haven, Connecticut;

17Rockefeller University, New York, New York;

18Department of Urology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts;

18Department of Urology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts;

19Renal Section, Department of Medicine and Pathology, Boston University Medical Center, Boston, Massachusetts;

20Institute of Human Genetics and

21Department of Neonatology and Pediatric Intensive Care, Children’s Hospital, University of Bonn, Bonn, Germany; and

22Medical Faculty Skopje, University Children’s Hospital, Skopje, Macedonia

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

1Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;