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Lectin characterization of cystogenesis in the SBM transgenic model of polycystic kidney disease.

V D'Agati and M Trudel
JASN October 1992, 3 (4) 975-983;
V D'Agati
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M Trudel
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Abstract

The generation of a novel transgenic mouse model of polycystic kidney disease with a construct (SBM) that links the coding region of the c-myc proto-oncogene to the simian virus 40 enhancer and beta-globin promoter was previously reported (see reference 1). In order to determine the site of origin and histogenesis of renal cysts in this model, lectin/immunohistochemical and electron microscopic studies on mice of varying ages (from birth to adulthood) are described here. Cysts are detectable at birth and increase in number and diameter with age. Cysts predominantly involve the collecting tubules of young transgenic mice but progressively affect the proximal tubules with advancing age. A minority of cysts are of distal tubular origin in all age groups studied. Tubular hyperplasias are primarily reactive with proximal tubular markers and appear to precede the development of proximal tubular cysts in adult mice. This particular phenotypic evolution of polycystic kidney disease with advancing age suggests that the cystogenic potential of the transgene is modulated by yet unidentified tubular segment-specific responses.

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Journal of the American Society of Nephrology
Vol. 3, Issue 4
1 Oct 1992
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Lectin characterization of cystogenesis in the SBM transgenic model of polycystic kidney disease.
V D'Agati, M Trudel
JASN Oct 1992, 3 (4) 975-983;

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Lectin characterization of cystogenesis in the SBM transgenic model of polycystic kidney disease.
V D'Agati, M Trudel
JASN Oct 1992, 3 (4) 975-983;
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Cited By...

  • Cyst Formation in Kidney via B-Raf Signaling in the PKD2 Transgenic Mice
  • Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules
  • Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
  • Proapoptotic Fas Ligand Is Expressed by Normal Kidney Tubular Epithelium and Injured Glomeruli
  • Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development
  • C-MYC-induced Apoptosis in Polycystic Kidney Disease Is Bcl-2 and p53 Independent
  • Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development
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