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Expression of vascular cell adhesion molecule-1 in human renal allografts.

D M Briscoe, J S Pober, W E Harmon and R S Cotran
JASN November 1992, 3 (5) 1180-1185;
D M Briscoe
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J S Pober
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W E Harmon
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R S Cotran
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Abstract

The expression of vascular cell adhesion molecule-1 (VCAM-1) in 11 human renal allograft biopsies and 3 normal kidney specimens was investigated by immunocytochemistry. VCAM-1 expression was correlated with the degree of CD3+ T cell infiltration and the clinicopathologic diagnosis of acute rejection. CD3+ infiltrates were seen in all biopsies with rejection, but not in normal biopsies or one with acute tubular necrosis, and were accompanied by CD68+ monocyte/macrophage infiltrates. In normal biopsies, VCAM-1 was present on occasional tubules, where its expression was patchy and restricted to the basolateral surface of cells with slight cytoplasmic staining. The total number of tubules expressing VCAM-1 significantly increased in specimens infiltrated with CD3+ T cells. Moreover, in these infiltrated biopsy specimens, VCAM-1 was present throughout the cytoplasm of tubular cells concentrated on the basolateral surface. VCAM-1 was also observed on vascular endothelial cells where its expression correlated with the degree of CD3+ infiltrate. Mean scores (0 to 3+) for endothelial VCAM-1 expression increased from 0 (CD3+ score, 0) to a mean score of 2.25 in association with CD3+ T cell infiltrates (CD3+ score, 3). Endothelial VCAM-1 was predominantly on vessels in areas of infiltrate, including peritubular capillaries, venules, and arterioles, but was notably absent on glomerular endothelium. VCAM-1 also stained mesangial cells in an occasional CD3+ infiltrated specimen. It was concluded that the expression of VCAM-1 is increased on renal tubules and renovascular endothelium in rejecting renal allografts in association with CD3+ infiltrates.(ABSTRACT TRUNCATED AT 250 WORDS)

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Journal of the American Society of Nephrology
Vol. 3, Issue 5
1 Nov 1992
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Expression of vascular cell adhesion molecule-1 in human renal allografts.
D M Briscoe, J S Pober, W E Harmon, R S Cotran
JASN Nov 1992, 3 (5) 1180-1185;

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Expression of vascular cell adhesion molecule-1 in human renal allografts.
D M Briscoe, J S Pober, W E Harmon, R S Cotran
JASN Nov 1992, 3 (5) 1180-1185;
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Cited By...

  • I{kappa}B Kinase Is Critical for TNF-{alpha}-Induced VCAM1 Gene Expression in Renal Tubular Epithelial Cells
  • The Role of Adhesion Molecules in Human Leukocyte Attachment to Porcine Vascular Endothelium: Implications for Xenotransplantation
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