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Basic Research
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Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

Brian Ezekian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, John S. Yi, Felicitas Smith, Danae Olaso, Frances M. Saccoccio, Sallie Permar, Alton B. Farris, Jean Kwun and Stuart J. Knechtle
JASN December 2019, 30 (12) 2399-2411; DOI: https://doi.org/10.1681/ASN.2019030304
Brian Ezekian
1Department of Surgery, Duke Transplant Center,
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Paul M. Schroder
1Department of Surgery, Duke Transplant Center,
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Michael S. Mulvihill
1Department of Surgery, Duke Transplant Center,
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Andrew Barbas
1Department of Surgery, Duke Transplant Center,
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Bradley Collins
1Department of Surgery, Duke Transplant Center,
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Kyle Freischlag
1Department of Surgery, Duke Transplant Center,
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Janghoon Yoon
1Department of Surgery, Duke Transplant Center,
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John S. Yi
2Division of Surgical Sciences, Department of Surgery, Duke University, Durham, North Carolina; and
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Felicitas Smith
3Division of Laboratory Animal Resources, and
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Danae Olaso
1Department of Surgery, Duke Transplant Center,
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Frances M. Saccoccio
4Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina;
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Sallie Permar
4Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina;
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Alton B. Farris
5Department of Pathology, Emory School of Medicine, Atlanta, Georgia
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Jean Kwun
1Department of Surgery, Duke Transplant Center,
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Stuart J. Knechtle
1Department of Surgery, Duke Transplant Center,
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Article Information

vol. 30 no. 12 2399-2411
DOI 
https://doi.org/10.1681/ASN.2019030304
PubMed 
31658991

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication March 27, 2019
  • Accepted for publication September 17, 2019
  • Published online November 29, 2019.

Article Versions

  • Earlier version (October 28, 2019 - 09:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by the American Society of Nephrology

Author Information

  1. Brian Ezekian1,
  2. Paul M. Schroder1,
  3. Michael S. Mulvihill1,
  4. Andrew Barbas1,
  5. Bradley Collins1,
  6. Kyle Freischlag1,
  7. Janghoon Yoon1,
  8. John S. Yi2,
  9. Felicitas Smith3,
  10. Danae Olaso1,
  11. Frances M. Saccoccio4,
  12. Sallie Permar4,
  13. Alton B. Farris5,
  14. Jean Kwun1 and
  15. Stuart J. Knechtle1
  1. 1Department of Surgery, Duke Transplant Center,
  2. 3Division of Laboratory Animal Resources, and
  3. 4Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina;
  4. 2Division of Surgical Sciences, Department of Surgery, Duke University, Durham, North Carolina; and
  5. 5Department of Pathology, Emory School of Medicine, Atlanta, Georgia
  1. Correspondence:
    Dr. Jean Kwun or Dr. Stuart J. Knechtle, Department of Surgery, Duke Transplant Center, Duke University Medical Center, 207 Research Drive, 362 Jones Building, Durham, NC 27710. E-mail: jean.kwun{at}duke.edu or stuart.knechtle{at}duke.edu
  • Present address: Dr. Frances M. Saccoccio, Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, Florida.

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Funding

  • National Institute of Allergy and Infectious Diseases

    U19AI131471

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Journal of the American Society of Nephrology: 30 (12)
Journal of the American Society of Nephrology
Vol. 30, Issue 12
December 2019
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Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients
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Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients
Brian Ezekian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, John S. Yi, Felicitas Smith, Danae Olaso, Frances M. Saccoccio, Sallie Permar, Alton B. Farris, Jean Kwun, Stuart J. Knechtle
JASN Dec 2019, 30 (12) 2399-2411; DOI: 10.1681/ASN.2019030304

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Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients
Brian Ezekian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, John S. Yi, Felicitas Smith, Danae Olaso, Frances M. Saccoccio, Sallie Permar, Alton B. Farris, Jean Kwun, Stuart J. Knechtle
JASN Dec 2019, 30 (12) 2399-2411; DOI: 10.1681/ASN.2019030304
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Keywords

  • desensitization
  • kidney transplantation
  • carfilzomib
  • belatacept
  • antibody-mediated rejection

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