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A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy

Jing-Fu Bao, Pan-Pan Hu, Qin-Ying She and Aiqing Li
JASN July 2020, 31 (7) 1423-1434; DOI: https://doi.org/10.1681/ASN.2020010081
Jing-Fu Bao
1State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Pan-Pan Hu
1State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Qin-Ying She
2National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
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Aiqing Li
1State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Abstract

Cardiac hypertrophy is a common feature in patients with CKD. Recent studies revealed that two phosphate regulators, fibroblast growth factor-23 and α-Klotho, are highly involved in the pathophysiologic process of CKD-induced cardiac hypertrophy. With decreasing renal function, elevated fibroblast growth factor-23 and decreased α-Klotho may contribute to cardiac hypertrophy by targeting the heart directly or by inducing systemic changes, such as vascular injury, hemodynamic disorders, and inflammation. However, several studies have demonstrated that disturbances in the fibroblast growth factor-23/α-Klotho axis do not lead to cardiac hypertrophy. In this review, we describe the cardiac effects of the fibroblast growth factor-23/α-Klotho axis and summarize recent progress in this field. In addition, we present not only the main controversies in this field but also provide possible directions to resolve these disputes.

  • fibroblast growth factor-23
  • α-Klotho
  • uremic cardiac hypertrophy
  • Copyright © 2020 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 31 (7)
Journal of the American Society of Nephrology
Vol. 31, Issue 7
July 2020
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A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy
Jing-Fu Bao, Pan-Pan Hu, Qin-Ying She, Aiqing Li
JASN Jul 2020, 31 (7) 1423-1434; DOI: 10.1681/ASN.2020010081

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A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy
Jing-Fu Bao, Pan-Pan Hu, Qin-Ying She, Aiqing Li
JASN Jul 2020, 31 (7) 1423-1434; DOI: 10.1681/ASN.2020010081
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  • Article
    • Abstract
    • Brief Introduction to the FGF-23/α-Klotho Axis
    • Cardiac Effects of FGF-23 in CKD
    • Cardiac Effects of Klotho in CKD
    • Combined Cardiac Effects of FGF-23 and Klotho in CKD
    • Indirect Cardiac Effects of FGF-23 and α-Klotho in CKD
    • Summary and Future Perspectives
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  • fibroblast growth factor-23
  • α-Klotho
  • uremic cardiac hypertrophy

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