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Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

Di Feng, Mukesh Kumar, Jan Muntel, Susan B. Gurley, Gabriel Birrane, Isaac E. Stillman, Lai Ding, Minxian Wang, Saima Ahmed, Johannes Schlondorff, Seth L. Alper, Tom Ferrante, Susan L. Marquez, Carlos F. Ng, Richard Novak, Donald E. Ingber, Hanno Steen and Martin R. Pollak
JASN July 2020, 31 (7) 1479-1495; DOI: https://doi.org/10.1681/ASN.2019101032
Di Feng
1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
2Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
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  • ORCID record for Di Feng
Mukesh Kumar
3Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
4F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children’s Hospital, Boston, Massachusetts
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Jan Muntel
5Biognosys AG, Schlieren, Switzerland
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Susan B. Gurley
6Division of Nephrology and Hypertension, Oregon Health & Science University, Portland, Oregon
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Gabriel Birrane
7Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
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Isaac E. Stillman
1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
8Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
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Lai Ding
9NeuroTechnology Studio, Program for Interdisciplinary Neuroscience, Brigham and Women’s Hospital, Boston, Massachusetts
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Minxian Wang
10Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts
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Saima Ahmed
3Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
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Johannes Schlondorff
1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
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Seth L. Alper
1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
10Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts
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Tom Ferrante
2Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
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Susan L. Marquez
2Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
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Carlos F. Ng
2Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
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Richard Novak
2Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
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Donald E. Ingber
2Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
11Vascular Biology Program, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
12Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
13Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts
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Hanno Steen
3Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
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Martin R. Pollak
1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
10Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts
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Journal of the American Society of Nephrology: 31 (7)
Journal of the American Society of Nephrology
Vol. 31, Issue 7
July 2020
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Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis
Di Feng, Mukesh Kumar, Jan Muntel, Susan B. Gurley, Gabriel Birrane, Isaac E. Stillman, Lai Ding, Minxian Wang, Saima Ahmed, Johannes Schlondorff, Seth L. Alper, Tom Ferrante, Susan L. Marquez, Carlos F. Ng, Richard Novak, Donald E. Ingber, Hanno Steen, Martin R. Pollak
JASN Jul 2020, 31 (7) 1479-1495; DOI: 10.1681/ASN.2019101032

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Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis
Di Feng, Mukesh Kumar, Jan Muntel, Susan B. Gurley, Gabriel Birrane, Isaac E. Stillman, Lai Ding, Minxian Wang, Saima Ahmed, Johannes Schlondorff, Seth L. Alper, Tom Ferrante, Susan L. Marquez, Carlos F. Ng, Richard Novak, Donald E. Ingber, Hanno Steen, Martin R. Pollak
JASN Jul 2020, 31 (7) 1479-1495; DOI: 10.1681/ASN.2019101032
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Keywords

  • chronic kidney disease
  • focal segmental glomerulosclerosis
  • glomerular disease
  • cytoskeleton
  • podocyte
  • proteinuria

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