On the cover: Schematic illustration of the proposed mechanism of secretin induced urinary HCO₃^- excretion. Ingestion of a meal will cause a transient alkalosis. Ingestion of a meal itself and/or metabolic alkalosis stimulates secretin release. This will increase plasma concentration of secretin. An increased plasma concentration of secretin will activate HCO₃^- secretion by β-ICs in the CCD. This will increase urine pH and [HCO₃^-] excretion and hereby help compensate metabolic alkalosis.