About the Cover
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Cover image
On the cover: Schematic illustration of the proposed mechanism of secretin induced urinary HCO3- excretion. Ingestion of a meal will cause a transient alkalosis. Ingestion of a meal itself and/or metabolic alkalosis stimulates secretin release. This will increase plasma concentration of secretin. An increased plasma concentration of secretin will activate HCO3- secretion by β-ICs in the CCD. This will increase urine pH and [HCO3-] excretion and hereby help compensate metabolic alkalosis.