AKI in Hospitalized Patients with COVID-19

AKI requiring dialysis was common and varied by need for ICU admimssion. While 19% of patients overall required dialysis, 32% of patients who were admitted to the ICU required dialysis.

Approximately a third of patients did not have renal recovery at discharge or post-hospitalization follow up. Proportion of patients with AKI stratified by recovery versus nonrecovery at discharge and discharge follow-up. Recovery of kidney function was stratified into recover and AKD defined as (1) recovery: difference in creatinine is ≤0.3 and creatinine change in percentage is ≤25%; (2) stage 1: difference in creatinine is >0.3 and creatinine change in percentage is ≤25% or creatinine change in percentage is >25% and ≤100%; (3) stage 2: creatinine change in percentage is >100% and ≤200%; and (4) stage 3: creatinine change in percentage is >200% or requiring dialysis 72 hours prior to discharge.

Trajectory of creatinine during the first 14 days of hospitalizations in patients who were discharged by recovery and nonrecovery which demonstrate the severity and prolonged nature of the AKI. We used local regression (loess) for smoothening creatinine values across the interval of 2 weeks posthospital admission to visualize trajectories by AKD category.