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Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases

Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni and Sandra Merscher
JASN January 2021, 32 (1) 9-31; DOI: https://doi.org/10.1681/ASN.2020050697
Yelena Drexler
Katz Family Division of Nephrology and Hypertension/Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida
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Judith Molina
Katz Family Division of Nephrology and Hypertension/Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida
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Alla Mitrofanova
Katz Family Division of Nephrology and Hypertension/Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida
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Alessia Fornoni
Katz Family Division of Nephrology and Hypertension/Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida
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Sandra Merscher
Katz Family Division of Nephrology and Hypertension/Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida
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Abstract

In the past few decades, sphingolipids and sphingolipid metabolites have gained attention because of their essential role in the pathogenesis and progression of kidney diseases. Studies in models of experimental and clinical nephropathies have described accumulation of sphingolipids and sphingolipid metabolites, and it has become clear that the intracellular sphingolipid composition of renal cells is an important determinant of renal function. Proper function of the glomerular filtration barrier depends heavily on the integrity of lipid rafts, which include sphingolipids as key components. In addition to contributing to the structural integrity of membranes, sphingolipid metabolites, such as sphingosine-1-phosphate (S1P), play important roles as second messengers regulating biologic processes, such as cell growth, differentiation, migration, and apoptosis. This review will focus on the role of S1P in renal cells and how aberrant extracellular and intracellular S1P signaling contributes to the pathogenesis and progression of kidney diseases.

  • kidney disease
  • sphingosine-1-phosphate
  • ceramide
  • sphingolipid metabolism
  • sphingolipids
  • Copyright © 2021 by the American Society of Nephrology
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Journal of the American Society of Nephrology: 32 (1)
Journal of the American Society of Nephrology
Vol. 32, Issue 1
January 2021
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Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
JASN Jan 2021, 32 (1) 9-31; DOI: 10.1681/ASN.2020050697

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Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
JASN Jan 2021, 32 (1) 9-31; DOI: 10.1681/ASN.2020050697
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  • Article
    • Abstract
    • Sphingolipids and Sphingolipid Metabolism
    • Intracellular S1P Signaling
    • eS1P Signaling
    • iS1P and eS1P Signaling in Renal Cells
    • iS1P and eS1P Signaling in Experimental Models of Kidney Disease and in Human Kidney Disease
    • Treatment Strategies Targeting iS1P and eS1P Signaling in Human Kidney Disease
    • Conclusions and Future Perspectives
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  • ceramide
  • sphingolipid metabolism
  • sphingolipids

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