Journal of the American Society of Nephrology: 32 (1)

January 2021; Volume 32,Issue 1

This Month's Highlights

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This Month's Highlights
JASN January 2021, 32 (1) i; DOI: https://doi.org/10.1681/ASN.2020111605

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Up Front Matters

Editorials
- Open Access
  COVID-19 and APOL1: Understanding Disease Mechanisms through Clinical Observation
  David J. Friedman
  
  JASN January 2021, 32 (1) 1-2; DOI: https://doi.org/10.1681/ASN.2020111629
  
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  The Aftermath of AKI: Recurrent AKI, Acute Kidney Disease, and CKD Progression
  Yumeng Wen and Chirag R. Parikh
  
  JASN January 2021, 32 (1) 2-4; DOI: https://doi.org/10.1681/ASN.2020091317
  
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- Open Access
  COVID-19–Associated Acute Kidney Injury: Learning from the First Wave
  Ron Wald and Sean M. Bagshaw
  
  JASN January 2021, 32 (1) 4-6; DOI: https://doi.org/10.1681/ASN.2020101401
  
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  Will Targeting Interleukin-6 in the Anemia of CKD Change Our Treatment Paradigm?
  Daniel W. Coyne and Robert Fleming
  
  JASN January 2021, 32 (1) 6-8; DOI: https://doi.org/10.1681/ASN.2020101476
  
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Review
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  Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases
  Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni and Sandra Merscher
  
  JASN January 2021, 32 (1) 9-31; DOI: https://doi.org/10.1681/ASN.2020050697
  
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Rapid Communication

Open Access
COVID-19–Associated Glomerular Disease
Aneesha A. Shetty, Ibrahim Tawhari, Luisa Safar-Boueri, Nay Seif, Ameen Alahmadi, Richard Gargiulo, Vikram Aggarwal, Irtaza Usman, Sergey Kisselev, Ali G. Gharavi, Yahspal Kanwar and Susan E. Quaggin

JASN January 2021, 32 (1) 33-40; DOI: https://doi.org/10.1681/ASN.2020060804

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Basic Research

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Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease
Chao Zhang, Bruno Balbo, Ming Ma, Jun Zhao, Xin Tian, Yuval Kluger and Stefan Somlo

JASN January 2021, 32 (1) 41-51; DOI: https://doi.org/10.1681/ASN.2020040511

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Deep Learning–Based Segmentation and Quantification in Experimental Kidney Histopathology
Nassim Bouteldja, Barbara M. Klinkhammer, Roman D. Bülow, Patrick Droste, Simon W. Otten, Saskia Freifrau von Stillfried, Julia Moellmann, Susan M. Sheehan, Ron Korstanje, Sylvia Menzel, Peter Bankhead, Matthias Mietsch, Charis Drummer, Michael Lehrke, Rafael Kramann, Jürgen Floege, Peter Boor and Dorit Merhof

JASN January 2021, 32 (1) 52-68; DOI: https://doi.org/10.1681/ASN.2020050597

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Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis
Juan de Dios Ruiz-Rosado, Frank Robledo-Avila, Hanna Cortado, Javier Rangel-Moreno, Sheryl S. Justice, Ching Yang, John David Spencer, Brian Becknell and Santiago Partida-Sanchez

JASN January 2021, 32 (1) 69-85; DOI: https://doi.org/10.1681/ASN.2020030362

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Transcriptomes of Major Proximal Tubule Cell Culture Models
Syed J. Khundmiri, Lihe Chen, Eleanor D. Lederer, Chin-Rang Yang and Mark A. Knepper

JASN January 2021, 32 (1) 86-97; DOI: https://doi.org/10.1681/ASN.2020010009

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Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy
Kishor Devalaraja-Narashimha, Karoline Meagher, Yifan Luo, Cong Huang, Theodore Kaplan, Anantharaman Muthuswamy, Gabor Halasz, Sarah Casanova, John O’Brien, Rebecca Peyser Boiarsky, John McWhirter, Hans Gartner, Yu Bai, Scott MacDonnell, Chien Liu, Ying Hu, Adrianna Latuszek, Yi Wei, Srinivasa Prasad, Tammy Huang, George Yancopoulos, Andrew Murphy, William Olson, Brian Zambrowicz, Lynn Macdonald and Lori G. Morton

JASN January 2021, 32 (1) 99-114; DOI: https://doi.org/10.1681/ASN.2020050698

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Clinical Epidemiology

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Association of Multiple Plasma Biomarker Concentrations with Progression of Prevalent Diabetic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study
Sarah J. Schrauben, Haochang Shou, Xiaoming Zhang, Amanda Hyre Anderson, Joseph V. Bonventre, Jing Chen, Steven Coca, Susan L. Furth, Jason H. Greenberg, Orlando M. Gutierrez, Joachim H. Ix, James P. Lash, Chirag R. Parikh, Casey M. Rebholz, Venkata Sabbisetti, Mark J. Sarnak, Michael G. Shlipak, Sushrut S. Waikar, Paul L. Kimmel, Ramachandran S. Vasan, Harold I. Feldman, Jeffrey R. Schelling and on behalf of the CKD Biomarkers Consortium and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators

JASN January 2021, 32 (1) 115-126; DOI: https://doi.org/10.1681/ASN.2020040487

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Open Access
Conventional and Genetic Evidence on the Association between Adiposity and CKD
Pengfei Zhu, William G. Herrington, Richard Haynes, Jonathan Emberson, Martin J. Landray, Cathie L.M. Sudlow, Mark Woodward, Colin Baigent, Sarah Lewington and Natalie Staplin

JASN January 2021, 32 (1) 127-137; DOI: https://doi.org/10.1681/ASN.2020050679

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Open Access
The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study
Simona Hapca, Moneeza K. Siddiqui, Ryan S.Y. Kwan, Michelle Lim, Shona Matthew, Alex S.F. Doney, Ewan R. Pearson, Colin N.A. Palmer, Samira Bell and on behalf of the BEAt-DKD Consortium

JASN January 2021, 32 (1) 138-150; DOI: https://doi.org/10.1681/ASN.2020030323

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Clinical Research

Open Access
AKI in Hospitalized Patients with COVID-19
Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Riccardo Miotto, Anuradha Lala, Arash Kia, Prem Timsina, Li Li, Robert Freeman, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin Fuster, Barbara Murphy, John C. He, Alexander W. Charney, Erwin P. Böttinger, Benjamin S. Glicksberg, Steven G. Coca, Girish N. Nadkarni and on behalf of the Mount Sinai COVID Informatics Center (MSCIC)

JASN January 2021, 32 (1) 151-160; DOI: https://doi.org/10.1681/ASN.2020050615

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Open Access
AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19
Shruti Gupta, Steven G. Coca, Lili Chan, Michal L. Melamed, Samantha K. Brenner, Salim S. Hayek, Anne Sutherland, Sonika Puri, Anand Srivastava, Amanda Leonberg-Yoo, Alexandre M. Shehata, Jennifer E. Flythe, Arash Rashidi, Edward J. Schenck, Nitender Goyal, S. Susan Hedayati, Rajany Dy, Anip Bansal, Ambarish Athavale, H. Bryant Nguyen, Anitha Vijayan, David M. Charytan, Carl E. Schulze, Min J. Joo, Allon N. Friedman, Jingjing Zhang, Marie Anne Sosa, Eric Judd, Juan Carlos Q. Velez, Mary Mallappallil, Roberta E. Redfern, Amar D. Bansal, Javier A. Neyra, Kathleen D. Liu, Amanda D. Renaghan, Marta Christov, Miklos Z. Molnar, Shreyak Sharma, Omer Kamal, Jeffery Owusu Boateng, Samuel A.P. Short, Andrew J. Admon, Meghan E. Sise, Wei Wang, Chirag R. Parikh, David E. Leaf and and the STOP-COVID Investigators

JASN January 2021, 32 (1) 161-176; DOI: https://doi.org/10.1681/ASN.2020060897

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Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation
Rebecca J. Lepping, Robert N. Montgomery, Palash Sharma, Jonathan D. Mahnken, Eric D. Vidoni, In-Young Choi, Mark J. Sarnak, William M. Brooks, Jeffrey M. Burns and Aditi Gupta

JASN January 2021, 32 (1) 177-187; DOI: https://doi.org/10.1681/ASN.2020050584

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Differences in 25-Hydroxyvitamin D Clearance by eGFR and Race: A Pharmacokinetic Study
Simon Hsu, Leila R. Zelnick, Yvonne S. Lin, Cora M. Best, Bryan Kestenbaum, Kenneth E. Thummel, Lynn M. Rose, Andrew N. Hoofnagle and Ian H. de Boer

JASN January 2021, 32 (1) 188-198; DOI: https://doi.org/10.1681/ASN.2020050625

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Open Access
Comparison of the Efficacy and Safety of Tacrolimus and Low-Dose Corticosteroid with High-Dose Corticosteroid for Minimal Change Nephrotic Syndrome in Adults
Ho Jun Chin, Dong-Wan Chae, Yong Chul Kim, Won Suk An, ChunGyoo Ihm, Dong-Chan Jin, Sung Gyun Kim, Yong-Lim Kim, Yong-Soo Kim, Yoon-Goo Kim, Ho Seok Koo, Jung Eun Lee, Kang Wook Lee, Jieun Oh, Jung Hwan Park, Hongsi Jiang, Hyuncheol Lee and Sang Koo Lee

JASN January 2021, 32 (1) 199-210; DOI: https://doi.org/10.1681/ASN.2019050546

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Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Pablo E. Pergola, Matt Devalaraja, Steven Fishbane, Michel Chonchol, Vandana S. Mathur, Mark T. Smith, Larry Lo, Kurt Herzog, Rahul Kakkar and Michael H. Davidson

JASN January 2021, 32 (1) 211-222; DOI: https://doi.org/10.1681/ASN.2020050595

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Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis
Veronica Arora, Suliman Khan, Ayman W. El-Hattab, Ratna Dua Puri, Maria Eugenia Rocha, Rijad Merdzanic, Omid Paknia, Christian Beetz, Arndt Rolfs, Aida M. Bertoli-Avella, Peter Bauer and Ishwar C. Verma

JASN January 2021, 32 (1) 223-228; DOI: https://doi.org/10.1681/ASN.2020040478

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Intracellular Phosphate and ATP Depletion Measured by Magnetic Resonance Spectroscopy in Patients Receiving Maintenance Hemodialysis
Guillaume Chazot, Sandrine Lemoine, Gabriel Kocevar, Emilie Kalbacher, Dominique Sappey-Marinier, Olivier Rouvière and Laurent Juillard

JASN January 2021, 32 (1) 229-237; DOI: https://doi.org/10.1681/ASN.2020050716

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Meta-Analysis

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Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis
Jaimon T. Kelly, Guobin Su, La Zhang, Xindong Qin, Skye Marshall, Ailema González-Ortiz, Catherine M. Clase, Katrina L. Campbell, Hong Xu and Juan-Jesus Carrero

JASN January 2021, 32 (1) 239-253; DOI: https://doi.org/10.1681/ASN.2020030384

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Letters to the Editor

Open Access
Post-Mortem Diagnostics in COVID-19 AKI, More Often but Timely
Jan G. Zijlstra, Matijs van Meurs and Jill Moser

JASN January 2021, 32 (1) 255; DOI: https://doi.org/10.1681/ASN.2020091263

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Open Access
Authors’ Reply
Jordan L. Rosenstock and Vanesa Bijol

JASN January 2021, 32 (1) 255-256; DOI: https://doi.org/10.1681/ASN.2020101479

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Complexities of eGFRs in a Study of Glomerular Physiology
Robert W. Steiner

JASN January 2021, 32 (1) 256-257; DOI: https://doi.org/10.1681/ASN.2020091364

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Authors’ Reply
Didier Collard, Lennart van de Velde, Liffert Vogt and Bert-Jan H. van den Born

JASN January 2021, 32 (1) 257-258; DOI: https://doi.org/10.1681/ASN.2020101478

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Table of Contents

This Month's Highlights

Up Front Matters

Editorials

Review

Rapid Communication

Basic Research

Clinical Epidemiology

Clinical Research

Meta-Analysis

Letters to the Editor

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