About the Cover
Looking for COVID information? All ASN Journal COVID articles are in the COVID-19 Research Collection or the COVID-19 In Context Collection. All articles are free.
Cover image
On the cover: A common feature of injury-related podocyte loss is the modification of the interconnecting slit membrane. In the present study, the authors exploit the involvement of the regulated activity of the cell surface expressed A Disintegrin and Metalloproteinase 10 (ADAM10, blue) in this process, as cell-cell adhesion proteins such as cadherins (green) are among the known ADAM10 substrates. The image summarizes the findings of the study. ADAM10 is specifically expressed at foot processes and dispensable for glomerular development (upper panel). Podocyte injury (middle panel) is induced by anti-podocyte antibodies (red) resulting in proteinuria (yellow circles) and podocyte detachment through cleavage of injury-induced cadherins resulting in Wnt signaling. The podocyte-specific deletion of ADAM10 (last panel) protects from ADAM10-mediated ectodomain shedding of injury-related cadherins, thereby stabilizing the slit membrane. Decreased protein and podocyte loss are the result.
Reference: Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, et al.: ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage. J Am Soc Nephrol 32: 1389–1408, 2021
Postmaster: Send changes of address to Customer Service, JASN Journal of the American Society of Nephrology, 1401 H Street, NW, Suite 900, Washington, DC 20005. JASN Journal of the American Society of Nephrology, ISSN 1046-6673 (Online: 1533-3450), is the official journal of the American Society of Nephrology and is published monthly by the American Society of Nephrology. Periodicals postage paid at Washington, DC, and at additional mailing offices.
Subscription rates: domestic individual $614; international individual, $614; domestic institutional, $2148; international institutional, $2303; single copy, $75. Subscription prices subject to change. Annual dues include $33 for journal subscription. To order, call 202-557-8360. Canadian GST is 895524239.
Publications Mail Agreement No. 41205019 Return Undeliverable Canadian Addresses to PO Box 503, RPO West Beaver Creek, Richmond Hill, ON L4B 4R6, Canada.
Copyright © 2021 by the American Society of Nephrology.