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Basic Research
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Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy

Xinfang Xie, Jingyi Li, Pan Liu, Manliu Wang, Li Gao, Feng Wan, Jicheng Lv, Hong Zhang and Jing Jin
JASN May 2022, 33 (5) 918-935; DOI: https://doi.org/10.1681/ASN.2021030372
Xinfang Xie
1Department of Medicine, Division of Nephrology and Hypertension, Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois
2Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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  • ORCID record for Xinfang Xie
Jingyi Li
3Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China
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Pan Liu
1Department of Medicine, Division of Nephrology and Hypertension, Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois
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Manliu Wang
3Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China
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Li Gao
1Department of Medicine, Division of Nephrology and Hypertension, Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois
4Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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Feng Wan
3Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China
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Jicheng Lv
3Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China
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Hong Zhang
3Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China
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Jing Jin
1Department of Medicine, Division of Nephrology and Hypertension, Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois
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Article Information

vol. 33 no. 5 918-935
DOI 
https://doi.org/10.1681/ASN.2021030372
PubMed 
35172987

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication March 19, 2021
  • Accepted for publication January 25, 2022
  • Published online April 29, 2022.

Article Versions

  • Earlier version (February 16, 2022 - 08:42).
  • Earlier version (March 15, 2022 - 08:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2022 by the American Society of Nephrology

Author Information

  1. Xinfang Xie1,2,
  2. Jingyi Li3,
  3. Pan Liu1,
  4. Manliu Wang3,
  5. Li Gao1,4,
  6. Feng Wan3,
  7. Jicheng Lv3,
  8. Hong Zhang3 and
  9. Jing Jin1
  1. 1Department of Medicine, Division of Nephrology and Hypertension, Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  2. 2Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
  3. 3Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China
  4. 4Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
  1. Correspondence:
    Dr. Jicheng Lv, Renal Division, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China, or Dr. Jing Jin, Northwestern University Feinberg School of Medicine, Simpson Querrey Biomedical Research Center, 303 E Superior Street, Chicago, IL 60611. Email: jichenglv75{at}gmail.com or jing.jin{at}northwestern.edu
  1. X.X. and J. Li contributed equally to this work.

Funding

  • National Natural Science Foundation of China

    81800639; 81925006

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Journal of the American Society of Nephrology: 33 (5)
Journal of the American Society of Nephrology
Vol. 33, Issue 5
May 2022
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Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy
Xinfang Xie, Jingyi Li, Pan Liu, Manliu Wang, Li Gao, Feng Wan, Jicheng Lv, Hong Zhang, Jing Jin
JASN May 2022, 33 (5) 918-935; DOI: 10.1681/ASN.2021030372

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Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy
Xinfang Xie, Jingyi Li, Pan Liu, Manliu Wang, Li Gao, Feng Wan, Jicheng Lv, Hong Zhang, Jing Jin
JASN May 2022, 33 (5) 918-935; DOI: 10.1681/ASN.2021030372
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Keywords

  • IgA nephropathy
  • IgA protease
  • AK183
  • Clostridium ramosum
  • Fc-fusion protein
  • neonatal Fc receptor/FcRn
  • recombinant biologics

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