Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Subject Collections
    • JASN Podcasts
    • Archives
    • Saved Searches
    • ASN Meeting Abstracts
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Subscriptions
  • More
    • About JASN
    • Alerts
    • Advertising
    • Editorial Fellowship Program
    • Feedback
    • Reprints
    • Impact Factor
  • ASN Kidney News
  • Other
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • CJASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Subject Collections
    • JASN Podcasts
    • Archives
    • Saved Searches
    • ASN Meeting Abstracts
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • Subscriptions
  • More
    • About JASN
    • Alerts
    • Advertising
    • Editorial Fellowship Program
    • Feedback
    • Reprints
    • Impact Factor
  • ASN Kidney News
  • Follow JASN on Twitter
  • Visit ASN on Facebook
  • Follow JASN on RSS
  • Community Forum
You have accessRestricted Access

Lean body mass estimation by creatinine kinetics.

P R Keshaviah, K D Nolph, H L Moore, B Prowant, P F Emerson, M Meyer, Z J Twardowski, R Khanna, L Ponferrada and A Collins
JASN January 1994, 4 (7) 1475-1485;
P R Keshaviah
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K D Nolph
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H L Moore
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B Prowant
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P F Emerson
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M Meyer
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Z J Twardowski
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R Khanna
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L Ponferrada
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A Collins
Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • View PDF
Loading

Abstract

A new technique for estimating lean body mass (LBM) from creatinine kinetics has been developed. It is based on the principle that creatinine production is proportional to LBM and that, in the steady state, creatinine production is equal to the sum of creatinine excretion (urinary and dialytic) and metabolic degradation. This technique was applied to 17 normal subjects, 26 stable, chronic hemodialysis (HD) patients, and 71 stable, chronic peritoneal dialysis (PD) patients. In the HD group, LBM was also determined by bioimpedance in 11 patients and calculated from total body water, measured as the volume of urea distribution of a sterile urea infusion, in 15 patients. In normal subjects and in the PD group, LBM was assessed by creatinine kinetics as well as by bioimpedance, near infrared, and anthropometric techniques. In the HD patients, LBM by creatinine kinetics correlated significantly with LBM from total body water and the bioimpedance technique. There was no statistical difference between the total body water and creatinine kinetics techniques, but the bioimpedance values were systematically higher than those obtained by the kinetic technique. In the PD group and in normal volunteers, LBM values by creatinine kinetics correlated significantly with the other methods but were lower. Forty-seven percent of the HD patients and 66% of the PD patients had significantly lower LBM by creatinine kinetics than expected for their sex and age. Estimation of LBM by creatinine kinetics is proposed as a simple and convenient technique for the routine nutritional assessment of dialysis patients.

  • Copyright © 1994 by American Society of Nephrology
PreviousNext
Back to top

In this issue

Journal of the American Society of Nephrology
Vol. 4, Issue 7
1 Jan 1994
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
View Selected Citations (0)
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in JASN.
Enter multiple addresses on separate lines or separate them with commas.
Lean body mass estimation by creatinine kinetics.
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Lean body mass estimation by creatinine kinetics.
P R Keshaviah, K D Nolph, H L Moore, B Prowant, P F Emerson, M Meyer, Z J Twardowski, R Khanna, L Ponferrada, A Collins
JASN Jan 1994, 4 (7) 1475-1485;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Lean body mass estimation by creatinine kinetics.
P R Keshaviah, K D Nolph, H L Moore, B Prowant, P F Emerson, M Meyer, Z J Twardowski, R Khanna, L Ponferrada, A Collins
JASN Jan 1994, 4 (7) 1475-1485;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • View PDF

Cited By...

  • Serum creatinine levels and risk of incident type 2 diabetes mellitus or dysglycemia in middle-aged Japanese men: a retrospective cohort study
  • Leptin/Adiponectin Ratio Is an Independent Predictor of Mortality in Nondiabetic Peritoneal Dialysis Patients
  • Dietary Micronutrient Intake in Peritoneal Dialysis Patients: Relationship with Nutrition and Inflammation Status
  • Urinary Creatinine Excretion Rate and Mortality in Persons With Coronary Artery Disease: The Heart and Soul Study
  • Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function: Response to Ziegelmeier et al.
  • Exercise in Maintenance Hemodialysis Patients Induces Transcriptional Changes in Genes Favoring Anabolic Muscle
  • Evaluation of handgrip strength as a nutritional marker and prognostic indicator in peritoneal dialysis patients
  • Resting Energy Expenditure and Subsequent Mortality Risk in Peritoneal Dialysis Patients
  • Google Scholar

Similar Articles

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Annual Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Author Resources
  • Editorial Fellowship Program
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • JASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About JASN
  • JASN Email Alerts
  • JASN Key Impact Information
  • JASN Podcasts
  • JASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe

© 2021 American Society of Nephrology

Print ISSN - 1046-6673 Online ISSN - 1533-3450

Powered by HighWire