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You have accessRestricted Access

Contrast nephrotoxicity.

B J Barrett
JASN August 1994, 5 (2) 125-137; DOI: https://doi.org/10.1681/ASN.V52125
B J Barrett
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Abstract

Iodinated contrast media have some nephrotoxic potential but rarely cause significant renal failure in patients with normally functioning kidneys. Patients with existing renal impairment, with or without diabetes, those with current congestive heart failure of Class III or IV, those with reduced effective arterial volume (e.g., nephrotic, cirrhotic), or those receiving drugs that may impair renal function or increase contrast nephrotoxicity are at higher risk. Contrast nephrotoxicity may be clinically important in patients with other factors simultaneously affecting the renal response to contrast or in whom acute renal failure would seriously affect prognosis. The pathogenesis of contrast nephrotoxicity probably involves a combination of direct tubular toxicity and renal ischemic injury. Knowledge of the pathogenetic pathways is accumulating and is leading to the discovery of rational specific prophylactic measures to reduce the burden of nephrotoxicity. After the efficacy of these measures has been established, they should be considered for use in patients at high risk. Existing data indicate a limited role for the newer low-osmolality media for the prevention of nephrotoxicity.

  • Copyright © 1994 by American Society of Nephrology
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Journal of the American Society of Nephrology
Vol. 5, Issue 2
1 Aug 1994
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Contrast nephrotoxicity.
B J Barrett
JASN Aug 1994, 5 (2) 125-137; DOI: 10.1681/ASN.V52125

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Contrast nephrotoxicity.
B J Barrett
JASN Aug 1994, 5 (2) 125-137; DOI: 10.1681/ASN.V52125
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Cited By...

  • Acute Kidney Injury and Iodinated Contrast Media
  • Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke: A Single-Center Experience
  • When does chest CT require contrast enhancement?
  • Evaluation of adverse reactions to contrast media in the hospital
  • Incidence and Outcomes of Contrast-Induced AKI Following Computed Tomography
  • Iodinated Contrast Media and Their Adverse Reactions
  • Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategies
  • The absent kidney in 99Tcm-MAG3 renogram: a dramatic reversible consequence of contrast nephrotoxicity superimposed on renal obstruction
  • "Renalism": Inappropriately Low Rates of Coronary Angiography in Elderly Individuals with Renal Insufficiency
  • Toward Proteomics in Uroscopy: Urinary Protein Profiles after Radiocontrast Medium Administration
  • Prevention of contrast nephropathy after cardiac catheterisation
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