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Early dietary protein restriction slows disease progression and lengthens survival in mice with polycystic kidney disease.

K Tomobe, D Philbrick, H M Aukema, W F Clark, M R Ogborn, A Parbtani, H Takahashi and B J Holub
JASN December 1994, 5 (6) 1355-1360; DOI: https://doi.org/10.1681/ASN.V561355
K Tomobe
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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D Philbrick
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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H M Aukema
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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W F Clark
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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M R Ogborn
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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A Parbtani
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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H Takahashi
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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B J Holub
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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Abstract

The objective of these studies was to examine the effects of early dietary protein restriction on disease progression and survival in the DBA/2FG-pcy (pcy) mouse model of polycystic kidney disease. Male pcy mice of 70 days of age were fed either a normal protein (NP, 25% casein) or a low-protein (LP, 6% casein) diet for 105 days. At the end of the dietary treatment, kidney weight, kidney weight relative to body weight and kidney water contents were almost 50% lower, and relative renal phospholipid and triglyceride contents were almost 50% higher, in mice fed the LP diet, indicating a marked reduction in the progression of cystic disease. Morphometric analyses also revealed a lower total and percent cyst area in kidneys derived from mice on the LP compared with the NP diet. There were no significant differences in final body weight, urine volume and osmolality, GFR, proteinuria, or plasma levels of protein and urea between these two groups. In a second study, it was found that all mice fed an NP diet from 70 days of age onward had died by 310 days of age, compared with a 42% survival rate in LP-fed mice at this age. Overall, the mean lifespan for pcy mice on the LP diet was 24% longer than that for those mice on the NP diet (310 +/- 20 versus 251 +/- 16 days; P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

  • Copyright © 1994 by American Society of Nephrology
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Journal of the American Society of Nephrology
Vol. 5, Issue 6
1 Dec 1994
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Early dietary protein restriction slows disease progression and lengthens survival in mice with polycystic kidney disease.
K Tomobe, D Philbrick, H M Aukema, W F Clark, M R Ogborn, A Parbtani, H Takahashi, B J Holub
JASN Dec 1994, 5 (6) 1355-1360; DOI: 10.1681/ASN.V561355

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Early dietary protein restriction slows disease progression and lengthens survival in mice with polycystic kidney disease.
K Tomobe, D Philbrick, H M Aukema, W F Clark, M R Ogborn, A Parbtani, H Takahashi, B J Holub
JASN Dec 1994, 5 (6) 1355-1360; DOI: 10.1681/ASN.V561355
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Cited By...

  • Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential
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  • High Dietary Fat Intake Increases Renal Cyst Disease Progression in Han:SPRD-cy Rats
  • Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level
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