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The antiproteinuric action of angiotensin-converting enzyme is dependent on kinin.

F N Hutchison, X Cui and S K Webster
JASN October 1995, 6 (4) 1216-1222; DOI: https://doi.org/10.1681/ASN.V641216
F N Hutchison
Division of Nephrology, Medical University of South Carolina, Charleston, USA.
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X Cui
Division of Nephrology, Medical University of South Carolina, Charleston, USA.
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S K Webster
Division of Nephrology, Medical University of South Carolina, Charleston, USA.
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Abstract

Converting enzyme inhibitors (CEI) reduce proteinuria in nephrotic humans and animals, but the mediator(s) of this effect has not been identified definitively. To determine whether enhanced kinin activity contributes to the antiproteinuric action of CEI, rats with passive Heymann nephritis were treated with the B2 kinin receptor antagonist HOE 140, 300 micrograms/kg per day, for 3 days and then the CEI enalapril (ENAL), 35 mg/kg per day, was given for another 4 days while HOE 140 was continued (HOE/ENAL). Additional groups of nephrotic rats were untreated (CON), received HOE 140 only (HOE), or received ENAL only. ENAL alone produced a > 60% decrease in albuminuria after 4 days, whereas HOE 140 alone had no effect on albuminuria. In HOE/ENAL, pretreatment with HOE 140 prevented the decrease in albuminuria observed in ENAL. GFR increased significantly over time in all groups but was not different among the groups on any day. The clearance of albumin decreased significantly in ENAL (P < 0.001) and was significantly lower than in CON, HOE, or HOE/ENAL on Day 10. The fractional clearance of albumin decreased in all groups as a result of the increase in GFR but was significantly lower in ENAL compared with the other three groups at Day 10 and was not different between CON, HOE, and HOE/ENAL. Plasma renin activity and concentration were increased significantly in both ENAL and HOE/ENAL, indicating that converting enzyme was effectively inhibited in both groups. It was concluded that enhanced kinin activity contributes to the antiproteinuric action of CEI in this model of nephrotic syndrome.

  • Copyright © 1995 by American Society of Nephrology
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Journal of the American Society of Nephrology
Vol. 6, Issue 4
1 Oct 1995
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The antiproteinuric action of angiotensin-converting enzyme is dependent on kinin.
F N Hutchison, X Cui, S K Webster
JASN Oct 1995, 6 (4) 1216-1222; DOI: 10.1681/ASN.V641216

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The antiproteinuric action of angiotensin-converting enzyme is dependent on kinin.
F N Hutchison, X Cui, S K Webster
JASN Oct 1995, 6 (4) 1216-1222; DOI: 10.1681/ASN.V641216
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Cited By...

  • Vasopeptidase Inhibition Affords Greater Renoprotection than Angiotensin-Converting Enzyme Inhibition Alone
  • Chronic Angiotensin II Infusion But Not Bradykinin Blockade Abolishes the Antiproteinuric Response to Angiotensin-Converting Enzyme Inhibition in Established Adriamycin Nephrosis
  • Polymorphisms in the Genes Encoding for Human Kinin Receptors and the Risk of End-Stage Renal Failure: Results of Transmission/Disequilibrium Test
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