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Another look at the relationship between protein intake and dialysis dose.

D E Uehlinger
JASN January 1996, 7 (1) 166-168;
D E Uehlinger
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Abstract

It seems reasonable to postulate that an observed relationship between dialysis dose and protein intake reflects improved nutrition with correction of uremic symptoms. This article demonstrates a purely statistical association between the two parameters--protein intake, expressed as normalized protein catabolic rate (NPCR), and dialysis dose quantified as KT/V [the product of urea clearance (K) and treatment time (T) divided by the distribution volume of urea (V)] in peritoneal dialysis. The use of random samples from independent normal distributions of K, V, and urea generation rate (G) for the calculation of KT/V and NPCR reveals that a statistical association is introduced when both protein intake and dialysis dose are normalized proportional to a common distribution V. Not the normalizing parameter V per se, but rather the variability of V accounts for the introduction of this statistical artifact.

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Journal of the American Society of Nephrology
Vol. 7, Issue 1
1 Jan 1996
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Another look at the relationship between protein intake and dialysis dose.
D E Uehlinger
JASN Jan 1996, 7 (1) 166-168;

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Another look at the relationship between protein intake and dialysis dose.
D E Uehlinger
JASN Jan 1996, 7 (1) 166-168;
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