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Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection.

C Van Kooten, J G Boonstra, M E Paape, F Fossiez, J Banchereau, S Lebecque, J A Bruijn, J W De Fijter, L A Van Es and M R Daha
JASN August 1998, 9 (8) 1526-1534;
C Van Kooten
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J G Boonstra
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M E Paape
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F Fossiez
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J Banchereau
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S Lebecque
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J A Bruijn
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J W De Fijter
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L A Van Es
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M R Daha
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Abstract

Local production of cytokines plays a critical role in the regulation of pathophysiologic processes leading to rejection of transplanted organs. In the present study, the possible role of interleukin-17 (IL-17), a recently identified cytokine with unique properties, was investigated. IL-17 is specifically produced by activated T cells, whereas biological activities are restricted to the activation of nonhematopoietic cells. In vitro, IL-17 induced primary human proximal tubular epithelial cells, a type of cell regulating local interstitial inflammatory responses, to secrete higher levels of IL-6, IL-8, and monocyte chemoattractant protein-1, but not of the chemokine RANTES. The effect was specific for IL-17, because it was completely abrogated by a neutralizing anti-IL-17 antibody and was demonstrated to be dose- and time-dependent. In addition, IL-17 increased the production of complement component C3 by human proximal tubular epithelial cells, but not of other complement components. Immunofluorescence showed expression of IL-17 in kidney biopsies from patients suffering from graft rejection (8 of 8 positive), whereas pretransplant biopsies and normal kidneys were negative (0 of 6). Analysis of whole kidney isolates confirmed the presence of IL-17 mRNA by reverse transcription-PCR. IL-17 expression could also be found in in vitro cultured and activated graft-infiltrating T cells. These results represent the first demonstration of IL-17 protein expression in pathologic conditions and suggest that IL-17 might be important in the regulation of local inflammatory responses.

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Journal of the American Society of Nephrology
Vol. 9, Issue 8
1 Aug 1998
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Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection.
C Van Kooten, J G Boonstra, M E Paape, F Fossiez, J Banchereau, S Lebecque, J A Bruijn, J W De Fijter, L A Van Es, M R Daha
JASN Aug 1998, 9 (8) 1526-1534;

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Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection.
C Van Kooten, J G Boonstra, M E Paape, F Fossiez, J Banchereau, S Lebecque, J A Bruijn, J W De Fijter, L A Van Es, M R Daha
JASN Aug 1998, 9 (8) 1526-1534;
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Cited By...

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