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Basic Research
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Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation

Kensuke Sasaki, Andrew S. Terker, Yu Pan, Zhilian Li, Shirong Cao, Yinqiu Wang, Aolei Niu, Suwan Wang, Xiaofeng Fan, Ming-Zhi Zhang and Raymond C. Harris
JASN February 2021, ASN.2020071010; DOI: https://doi.org/10.1681/ASN.2020071010
Kensuke Sasaki
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Andrew S. Terker
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Yu Pan
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Zhilian Li
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Shirong Cao
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Yinqiu Wang
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Aolei Niu
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Suwan Wang
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Xiaofeng Fan
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
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Ming-Zhi Zhang
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
3Vanderbilt University School of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee
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Raymond C. Harris
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
2Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee
3Vanderbilt University School of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee
4Department of Veterans Affairs, Nashville, Tennessee
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Article Information

ASN.2020071010
DOI 
https://doi.org/10.1681/ASN.2020071010
PubMed 
33619052

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication July 16, 2020
  • Accepted for publication December 29, 2020
  • Published online February 22, 2021.

Copyright & Usage 
Copyright © 2021 by the American Society of Nephrology

Author Information

  1. Kensuke Sasaki1,
  2. Andrew S. Terker1,
  3. Yu Pan1,
  4. Zhilian Li1,
  5. Shirong Cao1,
  6. Yinqiu Wang1,
  7. Aolei Niu1,
  8. Suwan Wang1,
  9. Xiaofeng Fan1,
  10. Ming-Zhi Zhang1,3 and
  11. Raymond C. Harris1,2,3,4
  1. 1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
  2. 2Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee
  3. 3Vanderbilt University School of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee
  4. 4Department of Veterans Affairs, Nashville, Tennessee
  1. Correspondence:
    Dr. Raymond C. Harris, C3321 or Ming-Zhi Zhang, S3223, Medical Center North, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232. Email: ray.harris{at}vanderbilt.edu or ming-zhi.zhang{at}vanderbilt.edu

Funding

  • National Institutes of Health

    DK51265; DK95785; DK62794; P30DK114809
  • VA Merit Award

    00507969
  • Vanderbilt Center for Kidney Disease

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Journal of the American Society of Nephrology: 32 (3)
Journal of the American Society of Nephrology
Vol. 32, Issue 3
March 2021
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Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation
Kensuke Sasaki, Andrew S. Terker, Yu Pan, Zhilian Li, Shirong Cao, Yinqiu Wang, Aolei Niu, Suwan Wang, Xiaofeng Fan, Ming-Zhi Zhang, Raymond C. Harris
JASN Feb 2021, ASN.2020071010; DOI: 10.1681/ASN.2020071010

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Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation
Kensuke Sasaki, Andrew S. Terker, Yu Pan, Zhilian Li, Shirong Cao, Yinqiu Wang, Aolei Niu, Suwan Wang, Xiaofeng Fan, Ming-Zhi Zhang, Raymond C. Harris
JASN Feb 2021, ASN.2020071010; DOI: 10.1681/ASN.2020071010
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