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Basic Research
Open Access

Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Clustering

Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Evelyne Lerut, Aleksandar Senev, Olivier Aubert, Elisabet Van Loon, Jasper Callemeyn, Marie-Paule Emonds, Amaryllis Van Craenenbroeck, Katrien De Vusser, Ben Sprangers, Maud Rabeyrin, Valérie Dubois, Dirk Kuypers, Maarten De Vos, Alexandre Loupy, Bart De Moor and Maarten Naesens
JASN April 2021, ASN.2020101418; DOI: https://doi.org/10.1681/ASN.2020101418
Thibaut Vaulet
1Department of Electrical Engineering, Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
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Gillian Divard
2Université de Paris, National Institutes of Health and Medical Research, Paris Translational Research Centre for Organ Transplantation, Paris, France
3Kidney Transplant Department, Necker Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
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Olivier Thaunat
4French National Institutes of Health and Medical Research, Lyon, France
5Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France
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Evelyne Lerut
6Department of Imaging and Pathology, University Hospitals Leuven, Leuven, Belgium
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Aleksandar Senev
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
8Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross—Flanders, Mechelen, Belgium
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Olivier Aubert
2Université de Paris, National Institutes of Health and Medical Research, Paris Translational Research Centre for Organ Transplantation, Paris, France
3Kidney Transplant Department, Necker Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
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Elisabet Van Loon
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
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  • ORCID record for Elisabet Van Loon
Jasper Callemeyn
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
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  • ORCID record for Jasper Callemeyn
Marie-Paule Emonds
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
8Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross—Flanders, Mechelen, Belgium
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Amaryllis Van Craenenbroeck
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
9Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium
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Katrien De Vusser
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
9Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium
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Ben Sprangers
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
9Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium
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Maud Rabeyrin
10Department of Pathology, Hospices Civils de Lyon, Bron, France
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Valérie Dubois
11French National Blood Service, Décines-Charpieu, France
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Dirk Kuypers
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
9Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium
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Maarten De Vos
1Department of Electrical Engineering, Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
12Department of Development and Regeneration, University Hospitals Leuven, KU Leuven, Leuven, Belgium
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Alexandre Loupy
2Université de Paris, National Institutes of Health and Medical Research, Paris Translational Research Centre for Organ Transplantation, Paris, France
3Kidney Transplant Department, Necker Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
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Bart De Moor
1Department of Electrical Engineering, Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
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Maarten Naesens
7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
9Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium
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Article Information

ASN.2020101418
DOI 
https://doi.org/10.1681/ASN.2020101418
PubMed 
33687976

Published By 
American Society of Nephrology
Print ISSN 
1046-6673
Online ISSN 
1533-3450
History 
  • Received for publication October 6, 2020
  • Accepted for publication January 4, 2021
  • Published online April 6, 2021.

Article Versions

  • Earlier version (March 9, 2021 - 07:02).
  • Earlier version (March 12, 2021 - 11:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by the American Society of Nephrology

Author Information

  1. Thibaut Vaulet1,
  2. Gillian Divard2,3,
  3. Olivier Thaunat4,5,
  4. Evelyne Lerut6,
  5. Aleksandar Senev7,8,
  6. Olivier Aubert2,3,
  7. Elisabet Van Loon7,
  8. Jasper Callemeyn7,
  9. Marie-Paule Emonds7,8,
  10. Amaryllis Van Craenenbroeck7,9,
  11. Katrien De Vusser7,9,
  12. Ben Sprangers7,9,
  13. Maud Rabeyrin10,
  14. Valérie Dubois11,
  15. Dirk Kuypers7,9,
  16. Maarten De Vos1,12,
  17. Alexandre Loupy2,3,
  18. Bart De Moor1 and
  19. Maarten Naesens7,9
  1. 1Department of Electrical Engineering, Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
  2. 2Université de Paris, National Institutes of Health and Medical Research, Paris Translational Research Centre for Organ Transplantation, Paris, France
  3. 3Kidney Transplant Department, Necker Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
  4. 4French National Institutes of Health and Medical Research, Lyon, France
  5. 5Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France
  6. 6Department of Imaging and Pathology, University Hospitals Leuven, Leuven, Belgium
  7. 7Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
  8. 8Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross—Flanders, Mechelen, Belgium
  9. 9Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium
  10. 10Department of Pathology, Hospices Civils de Lyon, Bron, France
  11. 11French National Blood Service, Décines-Charpieu, France
  12. 12Department of Development and Regeneration, University Hospitals Leuven, KU Leuven, Leuven, Belgium
  1. Correspondence:
    Prof. Maarten Naesens, Department of Microbiology, Immunology and Transplantation, KU Leuven, University of Leuven, Belgium. Email: maarten.naesens{at}kuleuven.be

Funding

  • The Research Foundation Flanders

    IWT.150199
  • KU Leuven

    C32/17/049; 1844019N; 1842919N; 1S93918N; 1143919N; 1196119N
  • Agence Nationale pour la Recherche

    ANR-16-CE17-0007-01
  • Fondation pour la Recherche médicale

    PME20180639518
  • KU Leuven

    C16/15/059; C32/16/013; C24/18/022
  • Industrial Research Fund

    Fellowship 13-0260; FWO; 30468160; I013218N
  • Flemish Government

    AI Research Program
  • VLAIO

    COT.2018.018
  • Industrial Projects

    HBC.2018.0405
  • European Research Council

    885682
  • Institut National de la Santé et de la Recherche Médicale

    ATIP Avenir
  • Fondation Bettencourt Schueller

  • Fondation pour la Recherche Médicale

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Journal of the American Society of Nephrology: 32 (4)
Journal of the American Society of Nephrology
Vol. 32, Issue 4
April 2021
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Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Clustering
Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Evelyne Lerut, Aleksandar Senev, Olivier Aubert, Elisabet Van Loon, Jasper Callemeyn, Marie-Paule Emonds, Amaryllis Van Craenenbroeck, Katrien De Vusser, Ben Sprangers, Maud Rabeyrin, Valérie Dubois, Dirk Kuypers, Maarten De Vos, Alexandre Loupy, Bart De Moor, Maarten Naesens
JASN Apr 2021, ASN.2020101418; DOI: 10.1681/ASN.2020101418

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Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Clustering
Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Evelyne Lerut, Aleksandar Senev, Olivier Aubert, Elisabet Van Loon, Jasper Callemeyn, Marie-Paule Emonds, Amaryllis Van Craenenbroeck, Katrien De Vusser, Ben Sprangers, Maud Rabeyrin, Valérie Dubois, Dirk Kuypers, Maarten De Vos, Alexandre Loupy, Bart De Moor, Maarten Naesens
JASN Apr 2021, ASN.2020101418; DOI: 10.1681/ASN.2020101418
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