RT Journal Article SR Electronic T1 Modified Glomerular Filtration Rate Estimating Equation for Chinese Patients with Chronic Kidney Disease JF Journal of the American Society of Nephrology JO J. Am. Soc. Nephrol. FD American Society of Nephrology SP 2937 OP 2944 DO 10.1681/ASN.2006040368 VO 17 IS 10 A1 Ma, Ying-Chun A1 Zuo, Li A1 Chen, Jiang-Hua A1 Luo, Qiong A1 Yu, Xue-Qing A1 Li, Ying A1 Xu, Jin-Sheng A1 Huang, Song-Min A1 Wang, Li-Ning A1 Huang, Wen A1 Wang, Mei A1 Xu, Guo-Bin A1 Wang, Hai-Yan YR 2006 UL http://jasn.asnjournals.org/content/17/10/2937.abstract AB The Modification of Diet in Renal Disease (MDRD) equations provide a rapid method of assessing GFR in patients with chronic kidney disease (CKD). However, previous research indicated that modification of these equations is necessary for application in Chinese patients with CKD. The objective of this study was to modify MDRD equations on the basis of the data from the Chinese CKD population and compare the diagnostic performance of the modified MDRD equations with that of the original MDRD equations across CKD stages in a multicenter, cross-sectional study of GFR estimation from plasma creatinine, demographic data, and clinical characteristics. A total of 684 adult patients with CKD, from nine geographic regions of China were selected. A random sample of 454 of these patients were included in the training sample set, and the remaining 230 patients were included in the testing sample set. With the use of the dual plasma sampling 99mTc-DTPA plasma clearance method as a reference for GFR measurement, the original MDRD equations were modified by two methods: First, by adding a racial factor for Chinese in the original MDRD equations, and, second, by applying multiple linear regression to the training sample and modifying the coefficient that is associated with each variable in the original MDRD equations and then validating in the testing sample and comparing it with the original MDRD equations. All modified MDRD equations showed significant performance improvement in bias, precision, and accuracy compared with the original MDRD equations, and the percentage of estimated GFR that did not deviate >30% from the reference GFR was >75%. The modified MDRD equations that were based on the Chinese patients with CKD offered significant advantages in different CKD stages and could be applied in clinical practice, at least in Chinese patients with CKD.