PT  - JOURNAL ARTICLE
AU  - Susztak, Katalin
AU  - Sharma, Kumar
AU  - Schiffer, Mario
AU  - McCue, Peter
AU  - Ciccone, Emilio
AU  - Böttinger, Erwin P.
TI  - Genomic Strategies for Diabetic Nephropathy
AID  - 10.1097/01.ASN.0000078035.81397.8A
DP  - 2003 Aug 01
TA  - Journal of the American Society of Nephrology
PG  - S271--S278
VI  - 14
IP  - suppl 3
4099  - http://jasn.asnjournals.org/content/14/suppl_3/S271.short
4100  - http://jasn.asnjournals.org/content/14/suppl_3/S271.full
SO  - J. Am. Soc. Nephrol.2003 Aug 01; 14
AB  - ABSTRACT. Insight into the molecular mechanisms that underlie the origin and progression of diabetic nephropathy remains limited in part because conventional research tools have restricted investigators to focus on single genes or isolated pathways. Microarray technologies provide opportunities for evaluating genetic factors and environmental effects at a genomic scale during the pathogenesis of diabetic nephropathy. Despite the enormous power of the microarray technology, there are several pitfalls that need to be considered. This article discusses conceptual, practical, statistical, and logistical considerations for the use of microarrays in studies of experimental and human diabetic renal disease. New knowledge in this field will facilitate new approaches for molecular diagnosis and drug discovery. E-mail: ksusztak@aecom.yu.edu